The anti-diabetic activity of polyphenols-rich vinegar extract in mice via regulating gut microbiota and liver inflammation

Xia, Ting; Zhang, Zhujun; Zhao, Yuxuan; Kang, Chaoyan; Zhang, Xianglong; Tian, Yinglei; Yu, Jiaqi; Cao, Hui; Wang, Min

doi:10.1016/j.foodchem.2022.133443

Cited by 17 publications

(6 citation statements)

References 42 publications

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“…SCFAs play a key role in intestinal motility and host metabolism, and they also stimulate β-cell activity and thus exert hypoglycemic effects . Acetic acid, the most abundant of SCFAs, is involved in triglyceride synthesis and contributes to the regulation of insulin signaling and suppression of systemic inflammation. , Propionic acid inhibits cholesterol synthesis and serves as a substrate for hepatic gluconeogenesis . Butyric acid improves hepatic glycolipid metabolism and is preferable to other SCFAs as a nutrient for colonic cells .…”

Section: Discussionmentioning

confidence: 99%

Effects on Diabetic Mice of Consuming Lipid Extracted from Foxtail Millet (Setaria italica): Gut Microbiota Analysis and Serum Metabolomics

Wang

Liu

et al. 2023

J. Agric. Food Chem.

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Millet and its components have received much extensive attention for their health benefits in mitigating metabolic diseases. Foxtail millet is rich in phytochemicals, including oil. However, the hypoglycemic capacity of foxtail millet oil has yet to be fully investigated. The present study explored the effects of consuming this oil as the lipid extract of foxtail millet (LEFM) on intestinal microbiota composition and metabolic function in diabetic mice. After eight weeks of LEFM supplementation, the blood glucose, insulin resistance index, and lipid accumulation of diabetic mice were significantly decreased. In addition, LEFM feeding modulated gut microbiota composition, reduced the abundance of harmful bacteria (Escherichia-Shigella, Peptococcus, and norank_f_Oscillospiraceae), induced a bloom of probiotics, especially short-chain fatty acid (SCFA)-producing bacteria (Adlercreutzia, Faecalibaculum, and Bifidobacterium), and increased SCFAs concentration. LEFM treatment altered serum metabolite levels, for instance, greatly increasing the levels of l-carnitine and l-glutamine and reducing S-acetyldihydrolipoamide-E and sphingosine. Overall, improvements in gut microbiota and metabolic function were associated with the hypoglycemic potential of LEFM.

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Section: Discussionmentioning

confidence: 99%

Effects on Diabetic Mice of Consuming Lipid Extracted from Foxtail Millet (Setaria italica): Gut Microbiota Analysis and Serum Metabolomics

Wang

Liu

et al. 2023

J. Agric. Food Chem.

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“…Accumulative evidence suggests that polyphenols are essential in preventing and managing T2D via two approaches: (1) The insulin-dependent approaches; this involves the pancreatic islet β-cell protection from hyperglycemia-induced oxidative stress [18,19], promotion of β-cell proliferation [20], activation of insulin signalling [21], and stimulation of pancreatic insulin secretion [22]. (2) Insulin-independent approaches include inhibition of glucose absorption [23], inhibition of digestive enzymes [24,25], increased disposal of postprandial glucose [26], and regulation of intestinal microbiota [27]. Therefore, the possibilities of new plant-based drugs for diabetes are not far-fetched.…”

Section: Discussionmentioning

confidence: 99%

Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose–Streptozotocin-Induced Diabetic Rats

Sanni,

Nkomozepi,

Islam

2023

IJMS

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Type 2 diabetes (T2D) is a global health challenge with increased morbidity and mortality rates yearly. Herbal medicine has provided an alternative approach to treating T2D with limited access to formal healthcare. Tectona grandis is being used traditionally in the treatment of diabetes. The present study investigated the antidiabetic potential of T. grandis leaves in different solvent extractions, and the crude extract that demonstrated the best activity was further fractionated through solvent–solvent partitioning. The ethyl acetate fraction of the ethanol crude extract showed the best antidiabetic activity in inhibiting α-glucosidase, delaying glucose absorption at the small intestine’s lumen, and enhancing the muscle’s postprandial glucose uptake. The ethyl acetate fraction was further elucidated for its ability to reduce hyperglycemia in diabetic rats. The ethyl acetate fraction significantly reduced high blood glucose levels in diabetic rats with concomitant modulation in stimulated insulin secretions through improved pancreatic β-cell function, insulin sensitivity by increasing liver glycogen content, and reduced elevated levels of liver glucose-6-phosphatase activity. These activities could be attributed to the phytochemical constituents of the plant.

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“…They are all provided by Jiancheng of Bioengineering Institute, Nanjing, China). The serum AST and ALT activities were detected by using assay kits according to the instructions, and the concentration of serum IL-1β and TNF-α were detected by using commercial ELISA kits (Number: RAB0335, Merck-Millipore, MN, USA) following the instructions [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Coix Seed Oil on High Fat Diet-Induced Obesity and Dyslipidemia

Chen

Xue

Dai

et al. 2022

Foods

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Dietary intervention is becoming more popular as a way to improve lipid metabolism and reduce the prevalence of diet-related chronic disorders. We evaluated the effects of several dietary oils on body weight, fat mass, liver weight, and tumor necrosis factor in obese mice given a high-fat diet (HFD) to discover if coix seed oil (CSO) had an anti-obesity impact. As compared to other dietary fats, CSO treatment considerably lowered body weight and liver index, successfully sup-pressed total cholesterol and triglyceride content, and raised liver lipid deposition and lipid metabolism problem induced by high fat intake. Furthermore, gas chromatography research revealed that CSO extracted by supercritical fluid, with 64% being CSO extracted by supercritical fluid, and the greatest amounts of capric acids and lauric acids being 35.28% and 22.21%, respectively. CSO contained a high content of medium-chain fatty acids and was able to modify hepatic fatty acid metabolism and lipid levels in HFD-induced obese mice. According to the results, CSO has the potential to replace dietary lipids as a promising functional lipid in the prevention of met-abolish disorders.

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The anti-diabetic activity of polyphenols-rich vinegar extract in mice via regulating gut microbiota and liver inflammation

Cited by 17 publications

References 42 publications

Effects on Diabetic Mice of Consuming Lipid Extracted from Foxtail Millet (Setaria italica): Gut Microbiota Analysis and Serum Metabolomics

Effects on Diabetic Mice of Consuming Lipid Extracted from Foxtail Millet (Setaria italica): Gut Microbiota Analysis and Serum Metabolomics

Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose–Streptozotocin-Induced Diabetic Rats

Effects of Coix Seed Oil on High Fat Diet-Induced Obesity and Dyslipidemia

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