The anti-candidal activity of Pelargonium graveolens essential oils against clinical isolates of Candida albicans

Abstract

Objectives: Candida albicans as important opportunistic dimorphic fungi can cause the life threatening infections in humans. In this study, we evaluated the anticandidal activities of six samples of Pelargonium graveolens essential oils against 31 clinical isolates of C. albicans. Materials and methods:The anti-candidal activity was performed by disc diffusion and micro-broth dilution assays. The chemical compositions of essential oils were analyzed by Gas Chromatography (GC) apparatus. Results: P. graveolens essential oil samples with citronellol (7.7-43.7%) and geraniol (19.3-48.5%) showed the same anti-candidal activity in two different methods. There is no significant difference between the inhibition zone diameters (19.3-24.1 mm), and the MIC and MFC values (1.06-1.48 and 1.5-1.72 μl/ml) of essential oil samples with different percent of citronellol and geraniol. Conclusion: Therefore, P. graveolens essential oils can be used as anti-candidal agent for further studies.

Anti-dermatophyte activity of Pelargonium graveolens essential oils against dermatophytes

“…The results of anti-dermatophyte effects of P. graveolens essential oils have not been in according to their anti-candidal effects. There was no significant difference in anti-candidal activities of six samples of P. graveolens essential oils with citronellol (7.7-43.7%) and geraniol (19.3-48.5%) against clinical isolates of C. albicans in regard to inhibition zone diameters and the MIC and MFC values [23].…”

Antifungal Properties of Some Commercial Extracts Against <i>Candida albicans</i>

“…The wells which content SB and growing culture serve as positive controls and this which content DMSO and SB non inoculated were used as negative controls. The microplate was incubated at 30°C for 48 h. MICs were defined as the lowest concentration of essential dilution that inhibits yeast growth after 48 h. MFC values were the first well showing no growth on Sabouraud dextrose agar [16].…”

Antifungal Efficacy of Ocimum Basilicum Essential Oil in Tissue Conditioner Against Candida Albicans: An In vitro Study

“…[ 12 , 13 ] Extracts and essential oils (EOs) have been used for antimicrobial, antifungal, anti-inflammatory, antioxidant, and antiviral actions. [ 14 ] Among the reported EO with anti-Candida activity were mint, basil, lavender, tea tree oil, peppermint, and geranium EO. [ 11 , 14 , 15 ] The EO affected mainly the cell wall and the membranes of C. albicans and caused changes in colony morphotypes and metabolic activities.…”

“…[ 14 ] Among the reported EO with anti-Candida activity were mint, basil, lavender, tea tree oil, peppermint, and geranium EO. [ 11 , 14 , 15 ] The EO affected mainly the cell wall and the membranes of C. albicans and caused changes in colony morphotypes and metabolic activities. [ 15 , 16 ]…”