The anti-aging activity of Lycium barbarum polysaccharide extracted by yeast fermentation: In vivo and in vitro studies

Wang, Ziwen; Sun, Qiuhong; Fang, Jiaxuan; Wang, Changtao; Wang, Dongdong; Li, Meng

doi:10.1016/j.ijbiomac.2022.04.184

Cited by 33 publications

(14 citation statements)

References 41 publications

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“…They also found that polysaccharides had good antioxidant activities. Wang et al [ 39 ] reported that LBPs extracted by different methods presented a solid ability to scavenge DPPH, hydroxyl free radicals, and superoxide anion radicals. In addition, LBPs could prolong the life span of nematodes under normal conditions, oxidative stress, and heat stress.…”

Section: Biological Function Of Lbpsmentioning

confidence: 99%

Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases

et al. 2023

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Oxidative stress is an imbalance between the increased production of reactive species and reduced antioxidant activity, which can cause a variety of disturbances including ocular diseases. Lycium barbarum polysaccharides (LBPs) are complex polysaccharides isolated from the fruit of L. barbarum, showing distinct roles in antioxidants. Moreover, it is relatively safe and non-toxic. In recent years, the antioxidant activities of LBPs have attracted remarkable attention. In order to illustrate its significance and underlying therapeutic value for vision, we comprehensively review the recent progress on the antioxidant mechanisms of LBP and its potential applications in ocular diseases, including diabetic retinopathy, hypertensive neuroretinopathy, age-related macular degeneration, retinitis pigmentosa, retinal ischemia/reperfusion injury, glaucoma, dry eye syndrome, and diabetic cataract.

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Section: Biological Function Of Lbpsmentioning

confidence: 99%

Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases

et al. 2023

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“…Its oxygen radical absorbance capacity values, which lie between 25,000 and 30,000, surpass those of other nutritionally beneficial fruits like pomegranates and blueberries, indicating its superior antioxidant capacity [6]. Its medicinal uses range from improving visual acuity [5,7,8], abdominal pain [5], dry cough, fatigue and headache [5], immune system support, cancer prevention [7,8], and antidiabetic activity [7,8] to increased longevity [8][9][10] and enhanced fertility [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis of Romanian Lycium Genotypes: Exploring BODYGUARD Genes for Stress Resistance Breeding

Ciceoi,

Asanica,

Luchian

et al. 2024

IJMS

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Goji berries, long valued in Traditional Chinese Medicine and Asian cuisine for their wide range of medicinal benefits, are now considered a ‘superfruit’ and functional food worldwide. Because of growing demand, Europe and North America are increasing their goji berry production, using goji berry varieties that are not originally from these regions. European breeding programs are focusing on producing Lycium varieties adapted to local conditions and market demands. By 2023, seven varieties of goji berries were successfully registered in Romania, developed using germplasm that originated from sources outside the country. A broader project focused on goji berry breeding was initiated in 2014 at USAMV Bucharest. In the present research, five cultivated and three wild L. barbarum genotypes were compared to analyse genetic variation at the whole genome level. In addition, a case study presents the differences in the genomic coding sequences of BODYGUARD (BDG) 3 and 4 genes from chromosomes 4, 8, and 9, which are involved in cuticle-related resistance. All three BDG genes show distinctive differences between the cultivated and wild-type genotypes at the SNP level. In the BDG 4 gene located on chromosome 8, 69% of SNPs differentiate the wild from the cultivated genotypes, while in BDG 3 on chromosome 4, 64% of SNPs could tell the difference between the wild and cultivated goji berry. The research also uncovered significant SNP and InDel differences between cultivated and wild genotypes, in the entire genome, providing crucial insights for goji berry breeders to support the development of goji berry cultivation in Romania.

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“…Their medicinal and nutritional properties are active, and their antioxidant and anti-aging effects have been proven to provide protection for the body [ 17 ]. Because of these, L. barbarum fruits are widely used as a functional food and medicine for health care and longevity worldwide [ 18 , 19 ]. One of their main traditional applications in China is visual acuity and vision protection [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

Yang

Zhao

et al. 2022

Molecules

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Vascular retinopathy is a pathological change in the retina caused by ocular or systemic vascular diseases that can lead to blurred vision and the risk of blindness. Lycium barbarum polysaccharides (LBPs) are extracted from the fruit of traditional Chinese medicine, L. barbarum. They have strong biological activities, including immune regulation, antioxidation, and neuroprotection, and have been shown to improve vision in numerous studies. At present, there is no systematic literature review of LBPs on vascular retinal prevention and treatment. We review the structural characterization and extraction methods of LBPs, focus on the mechanism and pharmacokinetics of LBPs in improving vascular retinopathy, and discuss the future clinical application and lack of work. LBPs are involved in the regulation of VEGF, Rho/ROCK, PI3K/Akt/mTOR, Nrf2/HO-1, AGEs/RAGE signaling pathways, which can alleviate the occurrence and development of vascular retinal diseases in an inflammatory response, oxidative stress, apoptosis, autophagy, and neuroprotection. LBPs are mainly absorbed by the small intestine and stomach and excreted through urine and feces. Their low bioavailability in vivo has led to the development of novel dosage forms, including multicompartment delivery systems and scaffolds. Data from the literature confirm the medicinal potential of LBPs as a new direction for the prevention and complementary treatment of vascular retinopathy.

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The anti-aging activity of Lycium barbarum polysaccharide extracted by yeast fermentation: In vivo and in vitro studies

Cited by 33 publications

References 41 publications

Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases

Distinct Role of Lycium barbarum L. Polysaccharides in Oxidative Stress-Related Ocular Diseases

Genomic Analysis of Romanian Lycium Genotypes: Exploring BODYGUARD Genes for Stress Resistance Breeding

Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

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