The Anthracycline Antitumor Agents Doxorubicin and Daunorubicin Reduce the Activity of <i>Candida albicans</i> Phospholipase B

Arai, Rika; Sugita, Takashi; Nishikawa, Akemi

doi:10.1111/j.1348-0421.2004.tb03477.x

Cited by 5 publications

(4 citation statements)

References 24 publications

(4 reference statements)

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“…The principal PL activity of C. albicans detected in the supernatants of the cultures is due to PL B activity. Activity of PL B can be reduced by anthracycline antitumour agents doxorubicin and daunorubicin 98 and by brief exposure to antimycotics 99 . By using a PCR‐based approach on the basis of degenerated primers, two PLB genes were cloned 92, 95, 96 .…”

Section: Extracellular and Intracellular Phospholipases Of C Albicansmentioning

confidence: 99%

Hydrolytic enzymes as virulence factors of Candida albicans

Schaller

Borelli

Körting

et al. 2005

Mycoses

458

354

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Candida albicans is a facultative pathogenic micro-organism that has developed several virulence traits enabling invasion of host tissues and avoidance of host defence mechanisms. Virulence factors that contribute to this process are the hydrolytic enzymes. Most of them are extracellularly secreted by the fungus. The most discussed hydrolytic enzymes produced by C. albicans are secreted aspartic proteinases (Saps). The role of these Saps for C. albicans infections was carefully evaluated in numerous studies, whereas only little is known about the physiological role of the secreted phospholipases (PL) and almost nothing about the involvement of lipases (Lip) in virulence. They may play an important role in the pathogenicity of candidosis and their hydrolytic activity probably has a number of possible functions in addition to the simple role of digesting molecules for nutrition. Saps as the best-studied member of this group of hydrolytic enzymes contribute to host tissue invasion by digesting or destroying cell membranes and by degrading host surface molecules. There is also some evidence that hydrolytic enzymes are able to attack cells and molecules of the host immune system to avoid or resist antimicrobial activity. High hydrolytic activity with broad substrate specificity has been found in several Candida species, most notably in C. albicans. This activity is attributed to multigene families with at least 10 members for Saps and Lips and several members for PL B. Distinct members of these gene families are differentially regulated in various Candida infections. In future, prevention and control of Candida infections might be achieved by pharmacological or immunological tools specifically modulated to inhibit virulence factors, e.g. the family of Saps.

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Section: Extracellular and Intracellular Phospholipases Of C Albicansmentioning

confidence: 99%

Hydrolytic enzymes as virulence factors of Candida albicans

Schaller

Borelli

Körting

et al. 2005

Mycoses

458

354

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“…DOX is an effective anthracycline anti-cancer drug, widely used in cancer therapy for various types of cancers, (Arai et al 2004;Mattioli et al 2004) and usage of DOX has been restricted due to its side effects which affects quality of life of patients (Arai et al 2004;Havsteen et al 1985;Hudis and Schmitz 2004;Kesik et al 2010). Clinical studies have shown that patients treated with DOX reportedly suffer from cardiac related problems (Ho et al 2010;Panjrath and Jain 2006;Sparano et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…However, cellular mechanisms of developed cardiac toxicity is not well studied. Doxorubicin (DOX) is a strong anti-cancer drug, which is used to treat variety of malignant tumors (Arai et al 2004;Mattioli et al 2004). DOX induced cardiac and muscle toxicity in nondiabetic patients and animal models is well documented (Alhowail et al 2019;Gorelik et al 2003;Hudis and Schmitz 2004;Johnson and Singla 2018;Pal et al 2012;Rudzinski et al 2007;Singal and Iliskovic 1998;Singla et al 2019b).…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals

Narasimhulu

Singla

2022

Can. J. Physiol. Pharmacol.

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Diabetic cancer patients treated with Doxorubicin (DOX), a potent chemotherapeutic drug induces cardiac toxicity. However, molecular mechanisms of cardiac toxicity in this specific disease progression in patients and animal models are completely unknown. Therefore, we designed a study to understand the effects of doxorubicin induced cardiac toxicity in diabetic animals and involved pathophysiological mechanisms. C57BL/6J mice were divided into DOX and diabetic (STZ) treated four groups; control, STZ, DOX and DOX+STZ. At Day 14, animals were sacrificed, echocardiography was used to examine heart function, heart and blood samples were collected to investigate apoptotic mechanisms (Caspase 3, BAX, Bcl2), inflammation and cardiac remodeling. Our data shows a significant (p<0.05) increase in glucose levels, apoptotic markers, monocyte infiltration at the site of apoptosis and triggered inflammatory immune response (TNF-α and IL-6), in DOX+STZ animals compared to control and experimental groups. We also observed significant (p<0.05) increase in myofibrillar area, fibrosis and significantly decreased (p<0.05) cardiac function in DOX-treated diabetic animals compared with controls. In conclusion, our data suggest that DOX-induces significantly increased apoptosis, fibrosis and structural alterations in diabetic hearts compared to non-diabetic animals.

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“…Phospholipase B and secretory aspartyl protease are major virulence factors. Of these, anthracycline compounds inhibit the activity of phospholipase B in a dose-dependent manner [21]. Doxorubicin also inhibits the replication of HIV [22], herpes simplex virus [23], dengue virus, and yellow fever virus [24].…”

Section: Discussionmentioning

confidence: 99%

In vitro Synergistic Effects of Anthracycline Antitumor Agents and Fluconazole Against Azole-Resistant Candida albicans Clinical Isolates

S¹

2013

J Dev Drugs

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The Anthracycline Antitumor Agents Doxorubicin and Daunorubicin Reduce the Activity of Candida albicans Phospholipase B

Cited by 5 publications

References 24 publications

Hydrolytic enzymes as virulence factors of Candida albicans

Hydrolytic enzymes as virulence factors of Candida albicans

Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals

In vitro Synergistic Effects of Anthracycline Antitumor Agents and Fluconazole Against Azole-Resistant Candida albicans Clinical Isolates

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