The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma

Huang, Kun; Gao, Ningning; Zhai, Qixi; Bian, Donglin; Wang, Difei; Wang, Xuemei

doi:10.1097/md.0000000000009712

Cited by 10 publications

(11 citation statements)

References 24 publications

(20 reference statements)

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“… 10 , 11 Whereas the correlation is reported for the nodules sized less than 1.5 mm and the risk of malignancy. 12 , 13 The current predicted model for thyroid malignancy is based on age, nodule size, and fine-needle aspiration cytopathology. 7 Ideally, surgeons require an algorithm(s) that finds the malignant potential of a nodule preoperatively to reduce unnecessary diagnostic methods.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Ultrasound Parameters of Thyroid Nodules and the Risk of Malignancy: A Retrospective Analysis

Wang

Sun

Zhao³

et al. 2020

Cancer Control

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Ultrasonography-guided fine-needle aspiration biopsy is the common choice for diagnosis of the suspected thyroid nodule. An algorithm(s) that finds the malignant potential of a nodule preoperatively, to overcome unnecessary diagnostic methods, does not exist. The objective of the study was to correlate thyroid nodule sizes measured by ultrasonography and risk of malignancy assessed by cytologic and histologic examinations. Data regarding fine-needle aspiration cytology and the results of histologic examinations of surgical specimens of 260 nodules were collected and analyzed. The macro or multiple calcifications, the complex echo pattern, and posterior region homogeneity were considered suspicious in ultrasonography. Bethesda system for classification of thyroid nodules was used for cytopathology. Histopathology performed as per the 2004 World Health Organization classification system. The benefit score analysis was performed for determination of clinical usefulness. Twenty-eight of 49 malignant nodules and 46 of 68 malignant nodules detected through ultrasound following fine-needle aspiration cytopathology and histopathology were <2 cm in size. A correlation was found for malignancy rate detected by ultrasonography-guided fine-needle aspiration cytology and those of the surgical specimen ( r = 0.945, P = .015, R 2 = 0.894). Ultrasonography-guided fine-needle aspiration cytology had 0.994 sensitivities, 0.721 accuracies, and 0.08 to 0.945 diagnostic confidence for the detection of malignant nodules. Nodule size less than 2 mm ( P = .011) was associated with the malignancy potential of thyroid nodules. Ultrasonography-guided fine-needle aspiration cytology had 19 (7%) results as a false negative and 1 (1%) results were false positive. Ultrasound-guided fine-needle aspiration cytopathology reported oversize of thyroid nodule than original but can predict the risk of malignancy. Level of Evidence: III.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Ultrasound Parameters of Thyroid Nodules and the Risk of Malignancy: A Retrospective Analysis

Wang

Sun

Zhao³

et al. 2020

Cancer Control

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“…In addition, patients with lateral cervical lymph node metastasis are frequently at least stage T1N1bM0, and they are more susceptible to recurrence and metastasis than patients with stage T1N1aM0. In addition, the cutoff criterion of the thyroid nodule size in the present study was 0.9 cm, mainly because if the nodule size is >9 mm, its risk of metastasis increases, compared with it risk decreasing if the size is <9 mm (41).…”

Section: Discussionmentioning

confidence: 71%

Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma

et al. 2020

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In the present study, the recurrence rate of papillary thyroid microcarcinoma (PTMC) was assessed by analyzing postoperative follow-up data of affected patients and its associations with BRAF V600E, clinical pathology and imaging factors were explored. A total of 506 patients with PTMC were selected who underwent surgery from January 2014 to March 2016. The maximal diameter of thyroid nodules was ≤1 cm and all patients who underwent BRAF V600E testing and evaluation for lymph node metastasis. Postoperatively, each patient was regularly followed up to detect recurrence. Categorical variables were comparatively analyzed using univariate Cox linear regression analysis to screen for protective and adverse factors influencing recurrence of PTMC. A stepwise Cox proportional hazards regression model analysis was performed to explore risk factors affecting recurrence. Among the 506 patients, 477 were followed up, 29 were lost to follow-up and 26 patients experienced recurrence. The 5-year recurrent rate of PTMC was 5.45%. The univariate Cox regression analysis indicated that PTMC recurrence was influenced by BRAF V600E, sex, multifocality, capsular invasion and lateral cervical lymph node metastasis (P<0.05), but not by age, tumor location on the thyroid, size, single central lymph node metastasis, distant metastasis and operative approach (P>0.05). The significant factors associated with recurrent PTMC were subjected to stepwise multivariate Cox proportional hazards regression model analysis and the results indicated that BRAF V600E, sex, multifocality and lateral cervical lymph node metastasis were independent factors influencing recurrence in patients with PTMC, with a statistically significant difference (P<0.05). In conclusion, BRAF V600E, sex, multifocality and lateral cervical lymph node metastasis are independent risk factors for recurrent PTMC. Patients and methods Research subjects. The independent ethics committee of China Medical University (Shenyang, China) approved this study. In total, 506 patients were included who underwent

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“…Similarly, Ma et al [15] found that predictors of PTMC included an aspect ratio > 1, apparent hypoechogenicity, and unclear border, with the aspect ratio > 1 being the most predictive. Huang et al [16] found that the anteroposterior diameter of thyroid nodules > 0.7 cm was statistically significant for differentiation of benign and malignant nodules. Therefore, the apparent hypoechogenicity, unclear border, an aspect ratio > 1, microcalcification and anteroposterior diameter > 0.7 cm are all characteristics that are related to PTMC.…”

Section: Gs-cd-usmentioning

confidence: 99%

Application of Ultrasonography in the Diagnosis and Management of Papillary Thyroid Microcarcinoma

Huang¹,

Liu²

2020

Advanced Ultrasound in Diagnosis and Therapy

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Thyroid carcinoma is the most common malignant tumor of the endocrine system. Nearly 90% of thyroid carcinomas are papillary type, of which many are thyroid papillary microcarcinoma (PTMC) with a maximum diameter≤1 cm. Highresolution ultrasound imaging plays an important role in evaluating PTMC and guiding biopsy for pathology as well as appropriate treatment. This review paper discusses the ultrasonography features of PTMC and explores the clinical value of ultrasonography with gene testing in the diagnosis and management of PTMC.

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The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma

Cited by 10 publications

References 24 publications

RETRACTED: Ultrasound Parameters of Thyroid Nodules and the Risk of Malignancy: A Retrospective Analysis

RETRACTED: Ultrasound Parameters of Thyroid Nodules and the Risk of Malignancy: A Retrospective Analysis

Associations of BRAF V600E, clinical pathology and imaging factors with the recurrence rate of papillary thyroid microcarcinoma

Application of Ultrasonography in the Diagnosis and Management of Papillary Thyroid Microcarcinoma

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