THE ANTERIOR PITUITARY AND ITS RELATION TO THE ADRENAL CORTEX IN WATER DIURESIS¹

Changes in Electrolytes and 17-Oxosteroids in the Rat Subjected to Cold Environment

“…The distinction between electrolyte and fluid shifts suggested by these haemato¬ crit changes of the adrenalectomized animal supports Joseph, Schweizer, Ulmer & Gaunt [1944] and Swingle & Remington [1944]. They present evidence that the adrenal cortex influences water balance by pathways other than electrolyte move¬ ment and show that whole cortical extracts and glucocorticoids are more active than either DCA and aldosterone in protecting both normal and adrenalectomized animals against water intoxication to which the latter are particularly susceptible.…”

The Water Metabolism of Newborn Infants and Animals

“…For instance, the rate of water absorption from the gastro-intestinal tract was measured and it was found that newborn rats absorbed water more slowly than adult animals of the same strain. This delay in the alimentary water absorption which may be due to adrenal cortical or anterior pituitary hypofunction (Clark, 1939;Gaunt, 1944;Joseph, Schweizer, Ulmer, and Gaunt, 1944) would by itself lead to some decrease in the rate of water excretion. However, it could be shown that this is only a minor factor which modified water diuresis in the newborn animals.…”