The Antagonism of Morphine Anesthesia by Naloxone

Hasbrouck, Jan D.

doi:10.1213/00000539-197150060-00011

Cited by 34 publications

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“…It is possible, therefore, that complete reversal might have occurred shortly after the injection, and that by the time the particular measurements were made the antagonist action was already declining. Thus these measurements might have represented an underestimate of the degree of reversal produced by naloxone.The return of respiratory depression after the administration of naloxone has been described in clinical practice (Hasbrouck, 1971;Kersh, 1973;Fink et al, 1968). These reports suggested that the duration of action of naloxone may be relatively short, but they contrast with the findings of Jasinski et al (1968), who found evidence of antagonist activity three to five hours later.…”

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confidence: 94%

“…The return of respiratory depression after the administration of naloxone has been described in clinical practice (Hasbrouck, 1971;Kersh, 1973;Fink et al, 1968). These reports suggested that the duration of action of naloxone may be relatively short, but they contrast with the findings of Jasinski et al (1968), who found evidence of antagonist activity three to five hours later.…”

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confidence: 94%

“…It also consistently produced complete reversal of the subjective effects of morphine. Previously it has been suggested that naloxone may selectively antagonize the respiratory depressant effect of morphine but allow the other effects to persist (Hasbrouck, 1971;Heisterkamp, 1972). The measurements of pain threshold made in this study showed clearly that naloxone antagonizes both the analgesic and respiratory effects of morphine.…”

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Cigarette Smoker's Bronchitis: The Effect of Relighting

Rimington¹

1974

BMJ

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dioxide while psychomotor function and blood pressure were unchanged. Thus the antagonist effect of naloxone could be expected only in the former values. Naloxone was effective in producing a large degree of reversal of the miosis, analgesia, and respiratory depression produced by the morphine. It also consistently produced complete reversal of the subjective effects of morphine. Previously it has been suggested that naloxone may selectively antagonize the respiratory depressant effect of morphine but allow the other effects to persist (Hasbrouck, 1971;Heisterkamp, 1972). The measurements of pain threshold made in this study showed clearly that naloxone antagonizes both the analgesic and respiratory effects of morphine.Immediately after the injection of naloxone the subjects were unaware of any residual effects of the morphine though in the first measurements made after the injection miosis and respiratory depression were still present. These measurements were made at about six and 12 minutes after naloxone had been given. It is possible, therefore, that complete reversal might have occurred shortly after the injection, and that by the time the particular measurements were made the antagonist action was already declining. Thus these measurements might have represented an underestimate of the degree of reversal produced by naloxone.The return of respiratory depression after the administration of naloxone has been described in clinical practice (Hasbrouck, 1971;Kersh, 1973;Fink et al., 1968). These reports suggested that the duration of action of naloxone may be relatively short, but they contrast with the findings of Jasinski et al. (1968)

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Cigarette Smoker's Bronchitis: The Effect of Relighting

Rimington¹

1974

BMJ

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“…Hasbrouck (1971) showed the reversal of morphineinduced respiratory depression and electroencephalographical changes in the postoperative period. It has been suggested that naloxone may preserve the analgesic action of morphine while effectively reversing respiratory depression (Hasbrouck, 1971;Heisterkamp, 1972). Jasinski et al (1968) showed that naloxone could antagonise the behavioural and pupillary effects of cyclazocine in addition to its respiratory depressant effect.…”

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confidence: 99%

“…Jasinski et al (1968) showed that naloxone could antagonise the behavioural and pupillary effects of cyclazocine in addition to its respiratory depressant effect. The duration of action of naloxone has been claimed to be several hours (Jasinski et al, 1968), but other investigators have suggested that it is very much shorter (Hasbrouck, 1971;Fink et al, 1968;Evans et al, 1973).…”

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Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects

Evans¹,

Hogg²,

Lunn³

et al. 1974

BMJ

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SummaryThe effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal. IntroductionIn conscious and anaesthetized subjects naloxone reverses the depressant effects of narcotics (Foldes et al., 1963(Foldes et al., , 1969Sadove et al., 1963). Hasbrouck (1971) showed the reversal of morphineinduced respiratory depression and electroencephalographical changes in the postoperative period. It has been suggested that naloxone may preserve the analgesic action of morphine while effectively reversing respiratory depression (Hasbrouck, 1971;Heisterkamp, 1972). Jasinski et al. (1968) showed that naloxone could antagonise the behavioural and pupillary effects of cyclazocine in addition to its respiratory depressant effect. The duration of action of naloxone has been claimed to be several hours (Jasinski et al., 1968), but other investigators have suggested that it is very much shorter (Hasbrouck, 1971;Fink et al., 1968;Evans et al., 1973).Naloxone is evidently an effective narcotic antagonist; its duration of action, however, and relative effect on analgesia and respiratory depression and on the subjective effects produced by narcotics are not yet clear. The antagonist properties of naloxone were therefore studied to elucidate these points.

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Naloxone

Moore¹

1980

Am J Dis Child

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\s=b\A case of propoxyphene hydrochloride (Darvon) poisoning was unresponsive to therapeutic doses of naloxone hydrochloride in a 2\m=1/2\-year-oldgirl. Following prolonged coma and artificial ventilation for three hours, the patient responded immediately to the intravenous administration of 2 mg of naloxone hydrochloride, which is 20 times the manufacturer's recommended dosage. Naloxone is the agent of choice in reversing the effects of narcotics and synthetic opiate derivatives, such as propoxyphene and pentazocine. The manufacturer's present recommended dosage may not be sufficient to reverse the effects of large narcotic ingestions. We therefore recommend that if there is no response within two minutes of the initial 0.01 mg/kg dosage of naloxone hydrochloride, a second dose 0.1 mg/kg (ten times the manufacturer's suggested dose) be given.

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The Antagonism of Morphine Anesthesia by Naloxone

Cited by 34 publications

References 0 publications

Cigarette Smoker's Bronchitis: The Effect of Relighting

Cigarette Smoker's Bronchitis: The Effect of Relighting

Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects

Naloxone

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