The anorexia of ageing: Physiopathology, prevalence, associated comorbidity and mortality. A systematic review

Malafarina, Vincenzo; Úriz-Otano, Francisco; Gil-Guerrero, Lucía; Iniesta, Raquel

doi:10.1016/j.maturitas.2013.01.016

Cited by 190 publications

(118 citation statements)

References 43 publications

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“…Among the most important causes of what is known as geriatric anorexia (a para-physiologic process associated to age) are alterations in taste and smell, changes in the hormones that regulate gastric and intestinal motility, and mood alterations (depression, loneliness and dementia, among others) [68].…”

Section: Discussionmentioning

confidence: 99%

Serum albumin and health in older people: Review and meta analysis

Cabrerizo¹,

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Serum albumin and health in older people: Review and meta analysis

Cabrerizo¹,

et al. 2015

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“…We would like to focus on agerelated changes, with a summary of changes in appetiteregulating mechanisms shown in Table 2. A thorough review of age-related changes in the secretion of hormones related to appetite was published by Malafarina et al (2013). Changes in activity of and sensitivity to peptides regulating appetite and feeding are important factors of physiological reduction of appetite in aging.…”

Section: Regulation Of Appetitementioning

confidence: 99%

Mechanisms of the anorexia of aging—a review

Wysokiński

Sobów

Kłoszewska

et al. 2015

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Many, even healthy, older people fail to adequately regulate food intake and experience loss of weight. Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). However, exact mechanisms of the anorexia of aging remain to be elucidated. Many neurobiological mechanisms may be secondary to age-related changes in body composition and not associated with anorexia per se. Therefore, further studies on pathophysiological mechanisms of the anorexia of aging should employ accurate measurement of body fat and lean mass. The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. Since this symptom can lead to dramatic consequences, early identification and effective interventions are needed. One of the most important goals in the geriatric care is to optimize nutritional status of the elderly.

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“…Vancomycin displays approximately 50% protein binding, primarily to albumin, in normal, healthy adults [10]. While age may not be directly correlated to hypoalbuminemia, the elderly patient population has alterations in taste and smell which have been associated with geriatric anorexia, ultimately leading to hypoalbuminemia secondary to malnutrition [11–14]. In patients 60 years or older, a reduction in albumin of up to 25% was observed compared with patients <40 years of age [15].…”

Section: Pharmacokinetic and Pharmacodynamic Considerations In The Elmentioning

confidence: 99%

Intravenous Vancomycin Dosing in the Elderly: A Focus on Clinical Issues and Practical Application

et al. 2016

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The elderly population can be divided into three distinct age groups: 65–74 years (young-old), 75–84 years (middle-old), and 85+ years (old-old). Despite evidence of a shift in leading causes for mortality in the elderly from infectious diseases to chronic conditions, infections are still a serious cause of death in this population. These patients are at increased risk due to weakened immune systems, an increased prevalence of underlying comorbidities, and decreased physiologic reserves to fight infection. Additionally, elderly patients, especially adults in institutional settings, are at an increased risk of colonization and subsequent infection with methicillin-resistant Staphylococcus aureus at a rate that is five times higher than in younger individuals, causing an increase in empiric and definitive vancomycin use. Elderly patients have unique characteristics that make dosing vancomycin a challenge for clinicians, such as increased volume of distribution and decreased renal function. Using the best available evidence, it is recommended to initiate lower empiric maintenance doses and monitor vancomycin serum concentrations earlier than steady state to accurately calculate drug elimination and make appropriate dose adjustments.

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The anorexia of ageing: Physiopathology, prevalence, associated comorbidity and mortality. A systematic review

Cited by 190 publications

References 43 publications

Serum albumin and health in older people: Review and meta analysis

Serum albumin and health in older people: Review and meta analysis

Mechanisms of the anorexia of aging—a review

Intravenous Vancomycin Dosing in the Elderly: A Focus on Clinical Issues and Practical Application

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