The anorectic and obese adolescent

Bruni, Vincenzina; Dei, Metella; Peruzzi, Elena; Seravalli, Viola

doi:10.1016/j.bpobgyn.2009.09.007

Cited by 5 publications

(1 citation statement)

References 86 publications

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“…A meta-analysis revealed elevated levels of total cholesterol, HDL, LDL, TG, and apolipoprotein B in acute ANO patients compared to controls, possibly due to increased exogenous lipid absorption resulting from intestinal ecology imbalance [ 45 ]. Research on adolescents suggested ANO induced damage to liver function as a potential cause for hypercholesterolemia and reduced clearance rates of many steroid hormones [ 46 ]. Moreover, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis during fasting in ANO patients can lead to increaseD plasma cortisol levels [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study

Gao,

Qin,

Jiao

et al. 2024

Transl Psychiatry

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Emerging evidence reveals associations between metabolic syndrome (MetS) and psychiatric disorders (PDs), although causality remains uncertain. Consequently, we conducted Mendelian randomization (MR) to systematically evaluate the causality between MetS and PDs. Linkage disequilibrium score regression estimated the heritability of PDs and their genetic correlations with MetS. In primary analyses, the main model employed inverse variance weighting method, with sensitivity analyses using various MR models to ensure robustness. Replication MR analyses, involving cohorts distinct from those in the primary analyses, were performed to validate the generalizability of the findings. Multivariable MR analyses were carried out to account for genetically predicted body mass index (BMI). As a result, genetic correlations of MetS with attention-deficit/hyperactivity disorder(ADHD), anorexia nervosa(ANO), major depressive disorder(MDD), and schizophrenia were identified. Causal effects of MetS on ADHD (OR: 1.59 [95% CI:1.45–1.74]), ANO (OR: 1.42 [95% CI:1.25–1.61]), MDD(OR: 1.23 [95% CI: 1.13–1.33]), and the effects of ADHD (OR: 1.03 [95% CI: 1.02–1.04]) and ANO (OR: 1.01 [95% CI: 1.01–1.02]) on MetS were observed in primary analyses. Results from sensitivity analyses and replication analyses were generally consistent with the primary analyses, confirming the robustness and generalizability of the findings. Associations between MetS and ADHD, as well as ANO persisted after adjusting for BMI, whereas the statistical significance of the association between MetS and MDD was no longer observable. These results contribute to a deeper understanding of the mechanisms underlying PDs, suggesting potential modifiable targets for public prevention and clinical intervention in specific PDs related to metabolic pathways.

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Section: Discussionmentioning

confidence: 99%