The annual incidence of diabetic complications in a population of patients with Type 1 and Type 2 diabetes

Abstract

This study provides baseline figures for rates of diabetic complications for Type 1 and Type 2 diabetes, and confirms the increased burden of macrovascular disease in Type 2 diabetes.

Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database

“…Our data using supporting evidence to confirm diagnosis among 80% of patients with a stroke code also agree with that of a previous GPRD cerebrovascular disease validation study [34]. We have also compared our rates of stroke in the comparison group without diabetes with that of the Oxford Vascular Study [36], and those in the diabetes group with those published by McAlpine et al [37], and the findings are remarkably consistent. Thus although we acknowledge that a database study such as this is limited in as far as the study population is not a true inception cohort, we believe that the data from this study are reliable and can be generalised to the UK.…”

Risk of myocardial infarction in men and women with type 2 diabetes in the UK: a cohort study using the General Practice Research Database

“…The rates of MI reported here are similar to those from other studies. For example in type 2 diabetes our rates for ages 65 to 84 years were 24.8 (95% CI 23.4-26.2) per 1,000 person-years for men and 19.3 (95% CI 18.1-20.6) per 1,000 person-years for women, compared with 32.9 (95% CI 25.2-43.0) and 22.9 (95% CI 16.7-31.2) in men and women respectively reported by McAlpine et al [13] for the same age-group. Our rates were lower than those reported for diabetes in a Finnish study, where the underlying rate of MI is higher than that in the UK [33].…”

“…Many published studies to date were either conducted in a population of one sex only [2,4], included people with type 1 diabetes [3,9,10] (which may affect the risk by age) or were limited to those under the age of 65 [11,12] thereby excluding a measure of risk for patients with the highest prevalence of type 2 diabetes. In addition, many studies were based on comparatively small cohorts from populations with a high underlying risk of MI [13,14] or were selected from secondary care [15] and consequently more likely to have worse disease progression. All of these limitations sometimes make it inappropriate to extrapolate rates and relative risks to other populations, and in particular to primary care, where the majority of decisions for early primary prevention in diabetes are made.…”

Hat die Inzidenz der dialysepflichtigen Niereninsuffizienz bei Diabetikern zugenommen?

“…Diabetes mellitus ist eine Krankheit mit sozialen und ökonomischen Konsequenzen [2], die sich hauptsächlich aus den aufwendig und kostspielig zu versorgenden diabetischen Folgeschäden ergeben. Die Endstadien dieser Folgeschäden, diabetische Retinopathie, Neuropathie und Nephropathie, weisen allerdings nur eine geringe Inzidenz und Prävalenz auf [1,3,6,11,15]. So wurde 1997 in Groß-britannien für die terminale Niereninsuffizienz eine Inzidenz von 6,4/1 000 Menschen mit Typ-1-Diabetes und von 5,0/1 000 Menschen mit Typ-2-Diabetes gefunden.…”

“…1,6/1 000 Patienten, die der Amputationen 3,2 bzw. 3,1/1 000 Patienten [15]. In Österreich betrugen im Jahre 2000 bei Menschen mit Diabetes die Inzidenzen der terminalen Niereninsuffizienz 3,8/1 000, der Erblindung 0,8/1 000 und der Amputation 1,5/1 000 [11].…”