The anhedonias: Clinical and neurobiological aspects

Olivares, J.M.; Berríos, Germán E.

doi:10.3109/13651509809115352

Cited by 10 publications

(5 citation statements)

References 134 publications

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“…It is well established that some psychiatric disorders are associated with a loss in the capacity to experience pleasure from stimuli such as food, drink, touch, or music, a deficit known as anhedonia [4,5]. Healthy populations also exhibit a wide range of individual differences in their hedonic capacity (anhedonia trait) [6,7], which has been related to differences in the brain reward system [8,9].…”

Section: Resultsmentioning

confidence: 99%

Dissociation between Musical and Monetary Reward Responses in Specific Musical Anhedonia

et al. 2014

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Music has been present in all human cultures since prehistory [1, 2], although it is not associated with any apparent biological advantages (such as food, sex, etc.) or utility value (such as money). Nevertheless, music is ranked among the highest sources of pleasure [3], and its important role in our society and culture has led to the assumption that the ability of music to induce pleasure is universal. However, this assumption has never been empirically tested. In the present report, we identified a group of healthy individuals without depression or generalized anhedonia who showed reduced behavioral pleasure ratings and no autonomic responses to pleasurable music, despite having normal musical perception capacities. These persons showed preserved behavioral and physiological responses to monetary reward, indicating that the low sensitivity to music was not due to a global hypofunction of the reward network. These results point to the existence of specific musical anhedonia and suggest that there may be individual differences in access to the reward system.

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Section: Resultsmentioning

confidence: 99%

Dissociation between Musical and Monetary Reward Responses in Specific Musical Anhedonia

et al. 2014

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“…Since Klein, new insights into anhedonia have come from many sources, for example, historiographical accounts [13][14][15], psychological theories of positive and negative affect [16], and the neuroscience of pleasure and anhedonia [17][18][19]. Clinical research has shown the importance of anhedonia (or positive affect as its counterpart) in, for example, the prediction of response and the subjective feeling of remission [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Anhedonia in Depressive Disorder: A Narrative Review

2020

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Since the introduction of DSM-III anhedonia has become a core depressive criterion and is defined as the loss of interest or pleasure. Although the origin of the word goes back to the end of the 19th century and numerous anhedonic symptoms are described in classic texts on depression, this centrality in the diagnosis of depression is only recent. Anhedonia is best described as a symptom complex with unclear boundaries cutting across the tripartite model of the mind (affect, volition, and cognition). Popular concepts of anhedonia pertain to the pleasure cycle and positive affectivity. These concepts partially overlap and are often mixed up, but clearly stem from different theoretical backgrounds: the affective science of reward processing versus more general, dimensional modelling of affect. The former concept seems more suitable to understand anhedonic emotions, the latter more suitable to understand anhedonic mood or trait. This narrative review covers the history of “anhedonia,” the different anhedonic phenomena, and psychopathological concepts. An attempt is made to go beyond a merely descriptive psychopathology. Neurobiological and psychological insights shed a light on how symptoms are made and interconnected; these insights possibly call for a new psychopathological language.

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“…We focused on the study of the patterns of SERT clustering in depression patients in relation to a scale that measures anhedonia symptoms, because anhedonia is not only considered a key symptom of depression (APA, 2013) but is also conceptualized as a specific endophenotype of MDD (Pizzagalli, 2014) and a predictor of treatment response (Spijker et al., 2001). The use of the SAAS scale to provide a possible correlation between anhedonia scores and SERT clusters was also motivated by the issue that the HDRS does not properly evaluate anhedonia symptoms (Berrios and Olivares, 1995; Olivares and Berrios, 1998). When we evaluated the SAAS scores of D-I and D-II naïve depression patients, we did not found any difference between the two groups (Rivera-Baltanas et al., 2015).…”

Section: Alterations In Sert and Serotonin 2a Receptor (5ht2a) In Permentioning

confidence: 99%

Patterns of Membrane Protein Clustering in Peripheral Lymphocytes as Predictors of Therapeutic Outcomes in Major Depressive Disorder

et al. 2019

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There is an utmost necessity of developing novel biomarkers of depression that result in a more efficacious use of current antidepressant drugs. The present report reviews and discusses a recent series of experiments that focused on analysis of membrane protein clustering in peripheral lymphocytes as putative biomarkers of therapeutic efficacy for major depressive disorder. This review recapitulates how the ideas were originated, and the main findings demonstrated that analysis of serotonin transporter and serotonin 2 A receptor clustering in peripheral lymphocytes of naïve depression patients resulted in a discrimination of two subpopulations of depressed patients that showed a differential response upon 8 weeks of antidepressant treatment. The paper also reviews the usefulness of animal models of depression for an initial evaluation of membrane protein clustering in lymphocytes, which provides a screening tool to determine additional proteins to be further evaluated in depression patients. Finally, the present review provides a brief discussion of the general field of biomarkers of depression in relation to therapeutic outcomes and suggests additional ideas to provide extra value to the reviewed studies.

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The anhedonias: Clinical and neurobiological aspects

Cited by 10 publications

References 134 publications

Dissociation between Musical and Monetary Reward Responses in Specific Musical Anhedonia

Dissociation between Musical and Monetary Reward Responses in Specific Musical Anhedonia

Anhedonia in Depressive Disorder: A Narrative Review

Patterns of Membrane Protein Clustering in Peripheral Lymphocytes as Predictors of Therapeutic Outcomes in Major Depressive Disorder

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