The Angiotensin II Type 1 Receptor Gene Polymorphism Is Associated With Coronary Artery Vasoconstriction

Amant, Carole; Hamon, Martial; Bauters, Christophe; Richard, Florence; Helbecque, Nicole; McFadden, Eugène; Escudero, Xavier; Lablanche, Jean‐Marc; Amouyel, Philippe; Bertrand, Michel E.

doi:10.1016/s0735-1097(96)00535-9

Cited by 106 publications

(57 citation statements)

References 19 publications

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“…This suggests that LDL cholesterol can modify receptor expression and thereby alter the renin angiotensin system status especially in persons with the AT1R AC/CC genotype. The A/C 1166 polymorphism was also shown to be associated with coronary vasoconstriction by Amant et al (35) and support the theory that the AT1 receptor polymorphism is involved in localized segmental hyper-reactivity in infarct-related vessels. Similar results are also documented by van Geel et al (36).…”

Section: Angiotensin II Type I Receptor (Atir)supporting

confidence: 64%

Genes of renin angiotensin system and coronary heart disease

Ashavaid

Shalia

Nair

et al. 2000

Indian J Clin Biochem

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Coronary constriction, proliferation of smooth muscle cells and arrhythmia are involved in the pathophysiology of coronary heart disease and its complications such as myocardial infarction and sudden death. All these effects are favoured by high angiotensin II levels. Angiotensin II is the main effector molecule of the renin angiotensin system and it acts through angiotensin II type receptors. Genetically determined differences in the expression of the components of this system could adversely affect angiotensin II concentration and subsequently heart. Consequently each component of this system represents a potential candidate in the etiology of cardiovascular disease. In this article we review the variation of the angiotensin I converting enzyme, angiotensin II type I receptor and angiotensinogen genes and their association with cardiovascular disease.

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Section: Angiotensin II Type I Receptor (Atir)supporting

confidence: 64%

Genes of renin angiotensin system and coronary heart disease

Ashavaid

Shalia

Nair

et al. 2000

Indian J Clin Biochem

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“…ACE, a key component of the renin-angiotensin system, is involved in the generation of angiotensin II, a potent vasoconstrictor peptide, and in the degradation of bradykinin, a potent vasoconstrictor (Erdös and Skidgel 1987). The components of the renin-angiotensin system, involved in blood pressure regulation and vascular smooth muscle cell proliferation, are important determinants of vasomotor tone (Amant et al 1997). The obtained results (Figs.…”

Section: Discussionmentioning

confidence: 64%

Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats

et al. 2014

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Obesity is a chronic metabolic disorder that is associated with numerous diseases including hyperlipidemia, diabetes mellitus, hypertension, atherosclerosis, cardiovascular disease, and cancer. Cinnamic acid is a phytochemical compound having many biological effects and could be considered for the management of obesity. This study is aimed to assess the possible anti-obesity and cardioprotective properties of cinnamic acid (CA) in high fat diet-fed rats (HFD). Male Wistar rats were divided into 4 groups. They received normal diet, HFD diet, HFD supplemented with fluvastatin (2 mg/kg/day) or cinnamic acid (30 mg/kg/day) for 7 weeks. The results showed an increase in body weight of HFD rats bỹ 27 % as compared to control group. Moreover, serum lipase activity underwent a significant rise by 103 % which led to an increase in the levels of total cholesterol (T-Ch), triglycerides (TG), LDL-cholesterol in serum of untreated HFD-fed rats. Furthermore, the concentration of leptin and angiotensinconverting enzyme (ACE) activity exhibited remarkable increases in serum of HFD-fed rats as compared to controls. Whereas, the administration of CA to HFD-fed rats improved the body weight gain and serum lipid profile and reverted back near to normal the activities of lipase and ACE. In addition, the echocardiography evidenced that CA is able to protect the aorta and aortic arch and avoided vasoconstriction by increasing their diameters and improved liver steatosis and kidney indices of toxicity. Overall, these results suggest that cinnamic acid exerts anti-obesity and antihypertensive effects through inhibition of lipid digestive enzymes and ACE.

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“…They found a polymorphism involving the presence (insertion, I) or absence (deletion, D) of a 287-bp Alu sequence of DNA in intron 16 17 One of these genetic variants (corresponding to an adenine/cytosine [A/C] base substitution at the 1166 position) has been associated with low blood pressure 18 and exaggerated vasomotion of normal coronary arteries. 19 An aetiologic relationship between hypertension and hormone-related cancer incidence has been suggested. Hypertension during pregnancy and after menopause has been positively associated with breast cancer risk in a small number of studies.…”

Section: Introductionmentioning

confidence: 99%

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Correa

Noronha

Nogueira-de-Souza

et al. 2009

J Renin Angiotensin Aldosterone Syst

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Introduction. We evaluated the association between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensinconverting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT 1 )-receptor A1166C polymorphisms. Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer. Results. The frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, χ 2 ); and for AT 1 -receptor were: AA, AC and CC (in %: cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, χ 2 ). The results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls. Conclusions. The ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. The ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible target for developing genetic markers for breast cancer.

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The Angiotensin II Type 1 Receptor Gene Polymorphism Is Associated With Coronary Artery Vasoconstriction

Abstract: The AT1 receptor gene polymorphism is associated with coronary vasomotion in humans.

Cited by 106 publications

References 19 publications

Genes of renin angiotensin system and coronary heart disease

Genes of renin angiotensin system and coronary heart disease

Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

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