The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels

Couly, G; Coltey, P.; Eichmann, Anne; Douarin, Nicole M. Le

doi:10.1016/0925-4773(95)00428-9

Cited by 153 publications

(120 citation statements)

References 24 publications

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“…At least in the mandibular repair site, we found no evidence of cells from the circulation that contributed in a major way to the repair process. Likewise, we did not observe a major contribution from endothelial cells, which in the head are derived from mesoderm (Couly et al, 1995). The presence of two distinct populations of skeletal stem cells in the adult might have clinical implications because if bones preferentially heal using cells that share the same embryonic origin, then reparative strategies may have to take this variable into account in order to be maximally effective.…”

Section: Discussionmentioning

confidence: 82%

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

et al. 2008

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The fetal skeleton arises from neural crest and from mesoderm. Here, we provide evidence that each lineage contributes a unique stem cell population to the regeneration of injured adult bones. Using Wnt1Cre::Z/EG mice we found that the neural crest-derived mandible heals with neural crest-derived skeletal stem cells, whereas the mesoderm-derived tibia heals with mesoderm-derived stem cells. We tested whether skeletal stem cells from each lineage were functionally interchangeable by grafting mesodermderived cells into mandibular defects, and vice versa. All of the grafting scenarios, except one, healed through the direct differentiation of skeletal stem cells into osteoblasts; when mesoderm-derived cells were transplanted into tibial defects they differentiated into osteoblasts but when transplanted into mandibular defects they differentiated into chondrocytes. A mismatch between the Hox gene expression status of the host and donor cells might be responsible for this aberration in bone repair. We found that initially, mandibular skeletal progenitor cells are Hox-negative but that they adopt a Hoxa11-positive profile when transplanted into a tibial defect. Conversely, tibial skeletal progenitor cells are Hox-positive and maintain this Hox status even when transplanted into a Hox-negative mandibular defect. Skeletal progenitor cells from the two lineages also show differences in osteogenic potential and proliferation, which translate into more robust in vivo bone regeneration by neural crest-derived cells. Thus, embryonic origin and Hox gene expression status distinguish neural crest-derived from mesoderm-derived skeletal progenitor cells, and both characteristics influence the process of adult bone regeneration.

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Section: Discussionmentioning

confidence: 82%

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

et al. 2008

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“…3c). It should be noted, however, that the endothelial cells of the stromal vessels from the forebrain choroid plexuses originate from the cephalic mesoderm and not from the neural crest as the rest of the connective tissue of the stroma [27]. In mice, such a dichotomy in the origin of the sus-and sub-tentorial meninges (and choroidal stroma) was also demonstrated [92].…”

Section: Understanding Choroid Plexus Developmentmentioning

confidence: 99%

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

et al. 2018

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The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar morphology explained by their developmental origin, and fulfill several functions essential for CNS homeostasis. They form a neuroprotective barrier preventing the accumulation of noxious compounds into the CSF and brain, and secrete CSF, which participates in the maintenance of a stable CNS internal environment. The CSF circulation plays an important role in volume transmission within the developing and adult brain, and CSF compartments are key to the immune surveillance of the CNS. In these contexts, the choroid plexuses are an important source of biologically active molecules involved in brain development, stem cell proliferation and differentiation, and brain repair. By sensing both physiological changes in brain homeostasis and peripheral or central insults such as inflammation, they also act as sentinels for the CNS. Finally, their role in the control of immune cell traffic between the blood and the CSF confers on the choroid plexuses a function in neuroimmune regulation and implicates them in neuroinflammation. The choroid plexuses, therefore, deserve more attention while investigating the pathophysiology of CNS diseases and related comorbidities.

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“…This mesoderm is the sole source of skeletal muscles in the head and, together with lateral mesoderm, generates all craniofacial plus some cardiac endothelial precursors (Noden, 1983b(Noden, , 1986(Noden, , 1991aCouly et al, 1992Couly et al, , 1995. Extraocular and branchial muscles initiate their development within paraxial mesoderm, but complete their differentiation and morphogenesis at peripheral locations populated by neural crest cells (Noden, 1983b(Noden, , 1986Couly et al, 1992;Köntges and Lumsden, 1996;Matsuoka et al, 2005;Gage et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Spatial relations between avian craniofacial neural crest and paraxial mesoderm cells

Evans

Noden

2006

Developmental Dynamics

162

177

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Fate maps based on quail-chick grafting of avian cephalic neural crest precursors and paraxial mesoderm cells have identified the majority of derivatives from each population but have not unequivocally resolved the precise locations of and population dynamics at the interface between them. The relation between these two mesenchymal tissues is especially critical for the development of skeletal muscles, because crest cells play an essential role in their differentiation and subsequent spatial organization. It is not known whether myogenic mesoderm and skeletogenic neural crest cells establish permanent relations while en route to their final destinations, or later at the sites where musculoskeletal morphogenesis is completed. We applied ␤-galactosidase-encoding, replication-incompetent retroviruses to paraxial mesoderm, to crest progenitors, or at the interface between mesodermal and overlying neural crest as both were en route to branchial or periocular regions in chick embryos. With respect to skeletal structures, the results identify the avian neural crest:mesoderm boundary at the junction of the supraorbital and calvarial regions of the frontal bone, lateral to the hypophyseal foramen, and rostral to laryngeal cartilages.

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The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels

Cited by 153 publications

References 24 publications

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

Spatial relations between avian craniofacial neural crest and paraxial mesoderm cells

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