The angiogenic potential of autogenous free omental graft in experimental tibial defects in rabbit: Short-term preliminary histopathological study

Oloumi, Mohammad Mehdi; Derakhshanfar, Amin; Molaei, Mohammad Mahdi; Tayyebi, M.

doi:10.1016/j.jeas.2006.02.002

Cited by 14 publications

(15 citation statements)

References 48 publications

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“…Greater antiinflammatory and angiogenic activity and accelerated collagen synthesis were seen in omental implantation group. Oloumi et al (2006) investigated the role of free autogenous omentum in vasculogenesis during the process of bone healing. They stated that free omental graft significantly promoted angiogenesis in repaired tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In our study the greater omentum was transplanted to the esophagus wound without vascular anastomosis. Oloumi et al (2006) suggested that considering the angiogenic factors present in the greater omentum, it can be used at defects with no need to direct vascular connection with the recipient bed.…”

Section: Discussionmentioning

confidence: 99%

“…In the previous studies, transposition of free omental graft has been used in revascularization procedure involving the chronically injured spinal cord (Zhang et al, 1989), head and neck deformities (Losken et al, 2002) and bone fractures (Oloumi et al, 2006). Bone marrow seems a logical candidate for tereatment of chronic wounds as it contains inflammatory cell progenitors, mesenchymal stem cells andmultipotent stem cells.…”

Section: Introductionmentioning

confidence: 99%

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The Role of a Combination of Autogenous Fresh Bone Marrow and Omental Free Graft in the Cervical Esophageal Wound Healing in Dogs

Azari¹,

Molaei²,

Kheirandish³

et al. 2010

American J. of Animal and Veterinary Sciences

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Problem statement: Esophageal surgery is associated with greater wound healing problems than surgery on other portion of the alimentary tract. Omentum and fresh bone marrow are rich source of angiogenic factors that promote the growth of blood vessels into wound tissue. The aim of this study was evaluation of the effects of a combination of autogenous fresh bone marrow and omental free graft in esophageal wound healing. Approach: This study was carried out on 8 male adult dogs, assigned into two equal treatment and control groups. All dogs underwent cervical esophagotomy and laparotomy operations, also bone marrow aspiratin, simultaneously. A 3 cm linear full thickness incision was made on the cervical esophagus and then sutured. In treatment group, A small piece of omentum was obtained from abdominal cavity and secured on esophageal suture line and then 1 mL of fresh bone marrow was injected into the omental graft and wound edge. In the control group, the suture line was left without any treatment and the harvested omentum and aspirated bone marrow were disposed. During this study, the dogs were examined clinically and they were euthanized 14 days after operation. The surgical site of esophagus was assessed macroscopically and then histopathologic samples were taken from the repaired tissue of esophageal wall. The samples were stained by hematoxylin-eosin and masson-trichorome. Results: The clinical evaluation of present study revealed that all dogs were healthy with no major postoperative complications. There was no significant difference based on macroscopic examination in surgical site of esophagus between the two groups. The microscopic study revealed that inflammatory cells, angiogenesis and granulation tissue formation in wound bed of the treatment group were significantly more than the control group. Conclusion: According to the results of this study, application of a combination of autogenously fresh bone marrow and free omental graft can improve wound healing process in esophageal incision wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of a Combination of Autogenous Fresh Bone Marrow and Omental Free Graft in the Cervical Esophageal Wound Healing in Dogs

Azari¹,

Molaei²,

Kheirandish³

et al. 2010

American J. of Animal and Veterinary Sciences

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“…27,28 Omental implantation in rat models has demonstrated angiogenesis mediated by basic fibroblast growth factor (bFGF) as well. 29 Angiogenesis is important to flap survival, and omental tissue has a proven molecular basis for this revascularization.…”

Section: Angiogenic Propertiesmentioning

confidence: 99%

The Omental Free Flap—A Review of Usage and Physiology

Mazzaferro

Song

Massand

et al. 2017

J reconstr Microsurg

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“…Experimental wound models show omental transposition promotes healing due to transforming growth factor-β1 and bFGF mediated angiogenesis. 25,26 Interestingly, this same physiological pathway is involved in the formation of omental adhesions following inflammation or surgery. From a therapeutic point of view, selectively inhibiting the cytokines involved may hold promise in preventing adhesion formation.…”

Section: Milky Spotsmentioning

confidence: 99%