The Angiogenic Factor PlGF Mediates a Neuroimmune Interaction in the Spleen to Allow the Onset of Hypertension

Carnevale, Daniela; Pallante, Fabio; Fardella, Valentina; Fardella, Stefania; Iacobucci, Roberta; Federici, Massimo; Cifelli, Giuseppe; Lucia, Massimiliano De; Lembo, Giuseppe

doi:10.1016/j.immuni.2014.11.002

Cited by 98 publications

(99 citation statements)

References 41 publications

(50 reference statements)

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“…17 In addition, a peripheral neuroimmune response in the spleen, mediated by celiac ganglion efferent nerve fibers, is essential for the development of hypertension. 18 The NADPH oxidase in antigen-presenting cells plays a role in their activation in hypertension, and inhibition of this enzyme blunts the vascular inflammation present in hypertension. 19,20 Innate Sensing of Injury Signature molecules of microbial origin (pathogen-associated molecular patterns) or molecules that are released by host cells in response to stress or damage (damage-associated molecular patterns [DAMPs]) can activate resident and innate immune cells via action on many germline-encoded pattern recognition receptors (PRRs).…”

Section: Complementmentioning

confidence: 99%

Immune Mechanisms in Arterial Hypertension

Wenzel¹,

Turner²,

Krebs³

et al. 2016

Journal of the American Society of Nephrology

169

148

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Traditionally, arterial hypertension and subsequent end-organ damage have been attributed to hemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign organisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune system overreacts to internal injury, such as prehypertension. Renal inflammation results in injury and impaired urinary sodium excretion, and vascular inflammation leads to endothelial dysfunction, increased vascular resistance, and arterial remodeling and stiffening. Notably, modulation of the immune response can reduce the severity of BP elevation and hypertensive endorgan damage in several animal models. Indeed, recent studies have improved our understanding of how the immune response affects the pathogenesis of arterial hypertension, but the remarkable advances in basic immunology made during the last few years still await translation to the field of hypertension. This review briefly summarizes recent advances in immunity and hypertension as well as hypertensive end-organ damage.

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Section: Complementmentioning

confidence: 99%

Immune Mechanisms in Arterial Hypertension

Wenzel¹,

Turner²,

Krebs³

et al. 2016

Journal of the American Society of Nephrology

169

148

View full text Add to dashboard Cite

show abstract

“…A role for T cells in hypertension was suggested by experiments in Rag-1 −/− mice, which were resistant to experimentally induced chronic hypertension, while repletion of the T cell compartment rendered the animals susceptible [126]. A recent study identified a link between the nervous system and a splenic T cell reservoir during chronic hypertension induced by angiotensin-II infusion [127]. Angiotensin II increases norepinephrine release from splenic nerve fibers originating in the celiac ganglion.…”

Section: Role Of the Pns In The Development Deployment And Homeostamentioning

confidence: 99%

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Ordovás-Montañés

Rakoff-Nahoum

Huang

et al. 2015

Trends in Immunology

145

123

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The nervous system and the immune system are the principal sensory interfaces between the internal and external environment. They are responsible for recognizing, integrating, and responding to varied stimuli, and have the capacity to form memories of these encounters leading to learned or ‘adaptive’ future responses. Here, we review the current understanding of the cross-regulation between these systems. The autonomic and somatosensory nervous systems regulate both the development and deployment of immune cells, with broad functions that impact hematopoiesis as well as priming, migration and cytokine production. In turn, specific immune cell subsets contribute to homeostatic neural circuits such as those controlling metabolism, hypertension and the inflammatory reflex. We examine the contribution of the somatosensory system to autoimmune, autoinflammatory, allergic, and infectious processes in barrier tissues and in this context, discuss opportunities for therapeutic manipulation of neuro-immune interactions.

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“…12 It is a model for postoperative wound healing, not for glaucoma. Nevertheless, since PlGF is upregulated in glaucomatous AH 10 and as there is evidence that PlGF is involved in the regulation of IOP (Abdulrazik M, et al IOVS 2010;51:ARVO E-Abstract 979), 11 we further investigated this hypothesis. First, SC administration of PlGF was tested and significantly increased eye pressures with 27% at 3 hours after administration.…”

Section: Discussionmentioning

confidence: 99%

“…11 Moreover, the upregulated PlGF levels in AH of glaucoma patients 10 also might suggest a role of PlGF in IOP regulation. Therefore, the effect of PlGF on eye pressure was investigated further in normotensive mice.…”

Section: Effect Of Plgf and 5d11d4 On Iop In Normotensive Micementioning

confidence: 99%

“…Indeed, it is known that subconjunctival administration of PlGF can increase the eye pressure in normotensive rabbits (Abdulrazik M, et al IOVS 2010;51:ARVO E-Abstract 979). Moreover, Carnevale et al 11 showed that PlGF can regulate the onset of systemic hypertension. Mice deficient in PlGF manifested protection from angiotensin II-induced hypertension, which could be ascribed to modulation of the splenic immune system.…”

mentioning

confidence: 99%

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