The Anemia of Scurvy

Abstract

1. Weight loss, progressive anemia, and a moderate increase in reticulated red blood cells occurred in seventeen guinea pigs on a diet deficient in vitamin C. 2. The histological changes of the bone marrow removed from guinea pigs with scurvy showed large numbers of erythrogenic cells, but scant evidence of active maturation to the adult erythrocyte. 3. A reticulocyte response was induced in guinea pigs with scurvy when fed orange juice daily. 4. The histological changes of the bone marrow removed from guinea pigs during the reticulocyte response showed large numbers of mitotic figures and relatively more adult red blood cells than in the bone marrow from guinea pigs with scurvy that had not been treated with orange juice. 5. It is concluded from this study that the anemia of experimentally induced scurvy in the guinea pig is largely dependent upon vitamin C deficiency resulting in retarded maturation of the red blood cell.

Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

“…There is little excuse for this sloppy technique. As early as 1919 Newcomer {20Jf.8) developed a satisfactory color disk for use in a colorimeter and defined the conditions of color development. Recently a nomogram has been devised (207) for correcting readings at various times after the addition of the acid and at various temperatures to the value obtained after sixty minutes at The sum of hemoglobin derivatives including sulfhemoglobin is determined.…”

“…For many years (1911)(1912)(1913)(1914)(1915)(1916)(1917)(1918)(1919)(1920)(1921)(1922)(1923)(1924)(1925)(1926) Fischer had assumed a tetrapyrrylethylene structure for bile pigments, while Ktister defended another more complicated formula. The correct tetrapyrrane formula was discovered in 1931 by Fischer and Hess (826) in an interesting manner.…”

“…1821,2579,3105); nicotinic acid(428,547,610,1013,1124,2235a); pantothenic acid(2745,2803); folic acid (cf. above); pterins(1820,2562,2819,2831,3128); vitamin D (53,545,959,1432,1547; cf.,however, 1806); ascorbic acid(428,643,722,911,1387,1814,1919,1920,1924,2331, * Cf. Heinle and Welch {1228a) and Bethell and co-workers {25!ta).2860…”