Abstract:The androgen receptor (AR) is expressed in 70-90% of invasive breast cancers. Despite the ubiquitous expression of AR in both primary and metastatic breast cancers, the clinical significance of this hormone receptor as a prognostic/predictive marker and its functional role in tumorigenesis remains poorly understood. This review summarizes the recent progress made in understanding the role of the AR as a prognostic/predictive marker in breast cancer and the underlying mechanisms by which the androgensignaling p… Show more
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