The ancient roots of nicotianamine: diversity, role, regulation and evolution of nicotianamine-like metallophores

Laffont, Clémentine; Arnoux, Pascal

doi:10.1039/d0mt00150c

Cited by 26 publications

(24 citation statements)

References 93 publications

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“…Interestingly, the signature motif in CntM which determines whether it uses pyruvate or α‐ketoglutarate as the substrate, was reported 19 . These findings will help the researchers to predict which kind of the nicotianamine‐like metallophores (Scheme 1) could be produced by a bacterium based on the gene sequences of its cnt operon 43 …”

Section: Resultsmentioning

confidence: 94%

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Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis

Luo

et al. 2021

FASEB j.

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Transition metals are indispensable nutrients for all cellular life and are frequently incorporated into metalloproteins to serve as essential cofactors. 1 The competition between pathogens and human cells for transition metals is an important component of the pathogenesis of infectious diseases, and hosts have developed a strategy known as "nutritional immunity" to restrict the pathogens from accessing essential transition metals to prevent microbial infection. 2 Bacteria have evolved various systems to subvert metal sequestration: elemental metal import, extracellular metal capture by metallophores, and metal acquisition from host metalloproteins, and these systems vary among species. [3][4] Metallophores are high-affinity

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Section: Resultsmentioning

confidence: 94%

“…19 These findings will help the researchers to predict which kind of the nicotianamine-like metallophores (Scheme 1) could be produced by a bacterium based on the gene sequences of its cnt operon. 43…”

Section: The N-c Linker Plays An Essential Role In D-his Bindingmentioning

confidence: 99%

Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis

Luo

et al. 2021

FASEB j.

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“…Ornithine decarboxylase is also worth noting as this enzyme synthesizes putrescine in plants, a polyamine involved in pathogen response (16) and suspected to be usurped by Hessian fly larvae to facilitate nutrient acquisition while feeding on wheat (17). In the same vein, a gene resembling the nicotianamine synthase, involved in the transport of various metal ions in plants (18), may facilitate acquisition of micronutrient by whiteflies. Finally, pectinesterase is a plant cell wall degrading enzyme (PCWDE) that is also found in plant and fungal pathogens causing maceration and soft-rotting of plant tissues.…”

Section: Resultsmentioning

confidence: 99%

Multiple horizontal acquisitions of plant genes in the whitefly Bemisia tabaci

Gilbert

Maumus

2022

Preprint

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The extent to which horizontal gene transfer (HGT) has shaped eukaryote evolution remains an open question. Two recent studies reported four plant-like genes acquired through two HGT events by the whitefly Bemisia tabaci, a major agricultural pest (Lapadula et al. 2020; Xia et al. 2021). Here, we performed a systematic search for plant-to-insect HGT in B. tabaci and uncovered a total of 50 plant-like genes deriving from at least 24 independent HGT events. Most of these genes are present in three cryptic B. tabaci species, show high level of amino-acid identity to plant genes (mean = 64%), are phylogenetically nested within plant sequences, and are expressed and evolve under purifying selection. The predicted functions of these genes suggest that most of them are involved in plant-insect interactions. Thus, substantial plant-to-insect HGT may have facilitated the evolution of B. tabaci towards adaptation to a large host spectrum. Our study shows that eukaryote-to-eukaryote HGT may be relatively common in some lineages and it provides new candidate genes that may be targeted to improve current control strategies against whiteflies.

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“…Methanobrevibacter ruminantium . Nicotianamine likely also facilitates metal uptake as it displays a high affinity for, and forms complexes with, several metal ions [ 110 ]. The other gene enriched in TS-2 is modB, which encodes the Molybdate ABC transporter permease protein ModB, a part of the molybdpterin biosynthesis pathway and methanogenesis [ 111 ].…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter

et al. 2021

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Background Dental calculus (mineralised dental plaque) preserves many types of microfossils and biomolecules, including microbial and host DNA, and ancient calculus are thus an important source of information regarding our ancestral human oral microbiome. In this study, we taxonomically characterised the dental calculus microbiome from 20 ancient human skeletal remains originating from Trentino-South Tyrol, Italy, dating from the Neolithic (6000–3500 BCE) to the Early Middle Ages (400–1000 CE). Results We found a high abundance of the archaeal genus Methanobrevibacter in the calculus. However, only a fraction of the sequences showed high similarity to Methanobrevibacter oralis, the only described Methanobrevibacter species in the human oral microbiome so far. To further investigate the diversity of this genus, we used de novo metagenome assembly to reconstruct 11 Methanobrevibacter genomes from the ancient calculus samples. Besides the presence of M. oralis in one of the samples, our phylogenetic analysis revealed two hitherto uncharacterised and unnamed oral Methanobrevibacter species that are prevalent in ancient calculus samples sampled from a broad range of geographical locations and time periods. Conclusions We have shown the potential of using de novo metagenomic assembly on ancient samples to explore microbial diversity and evolution. Our study suggests that there has been a possible shift in the human oral microbiome member Methanobrevibacter over the last millennia.

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The ancient roots of nicotianamine: diversity, role, regulation and evolution of nicotianamine-like metallophores

Abstract: Diversity of nicotianamine-like metallophores in plants, archaea and bacteria.

Cited by 26 publications

References 93 publications

Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis

Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis

Multiple horizontal acquisitions of plant genes in the whitefly Bemisia tabaci

Metagenomic analysis of ancient dental calculus reveals unexplored diversity of oral archaeal Methanobrevibacter

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