The ancestral type of the R-RAS protein has oncogenic potential
Antea Talajić,
Kristina Dominko,
Marija Lončarić
et al.
Abstract:Background
The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evolutionary conservation of R-RAS2, its links to basic cellular processes and its role in cancer, make R-RAS2 an interesting research topic. To elucidate the evolutionary history of R-RAS proteins, we investigated and compared structural and functional properties of ancestral type R-RAS protein with human R-RAS2.
Methods
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