The anatomical bases of semantic retrieval deficits in early Alzheimer's disease

Venneri, Annalena; McGeown, William J.; Hietanen, Heidi M.; Guerrini, Chiara; Ellis, Andrew W.; Shanks, Michael F.

doi:10.1016/j.neuropsychologia.2007.08.026

Cited by 81 publications

(75 citation statements)

References 63 publications

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“…Through the ‘consolidation process of lexical-semantic knowledge’, the words might be solidified in the brain. In fact, it has been reported that a significant positive correlation between age of acquisition values and gray matter density values was present in several brain regions including frontal regions bilaterally and the right parahippocampal, fusiform and lingual gyri [19]. Based on these hypotheses and our results, we find that the ‘earlier acquired words’ firmly stored in the mental lexicon might be more resistant to degenerative diseases with cognitive impairment such as AD.…”

Section: Discussionsupporting

confidence: 77%

Is Confrontation Naming Performance in Alzheimer’s Disease the Nominal Linguistic Retrogenesis of Normal Development?

et al. 2011

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We investigated confrontation naming performance of patients with Alzheimer’s disease (AD) and normal children (NC) to see if the nature of naming performance of AD patients is the reversal of that in normal development. Sixty items of the Boston Naming Test were given to 78 AD patients (and 40 age- and education-matched normal elderly) and 1,080 NC (3- to 14-year-olds). The analyses revealed that, firstly, the naming abilities of the AD patients demonstrated an inverse relationship with those of the NC. Secondly, from the clinical point of view, AD patients tended to lose vocabulary acquired later first while maintaining those acquired in earlier stages of development. Based on the findings, we claimed that this phenomenon was ‘a nominal retrogenesis’ in which ‘retrogenesis’ is ‘the process by which degenerative mechanisms reverse the order of acquisition in normal development’ as defined by Reisberg and colleagues.

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Section: Discussionsupporting

confidence: 77%

Is Confrontation Naming Performance in Alzheimer’s Disease the Nominal Linguistic Retrogenesis of Normal Development?

et al. 2011

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“…However, one recent study did not find a correlation between cortical thickness and semantic memory performance in a cognitively healthy elderly sample [17]. Interestingly, evidence has shown that people with neurodegenerative diseases display impairments on semantic memory measures [42,43], and their declined performance on semantic memory tests are positively correlated with the decreased GM volumes in their hippocampus and temporal cortex [42,44]. Discrepancies in the results of GM correlates of semantic memory in different samples suggest that the positive structure-function relationship is easier to detect when structural and functional measures are both in decline.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical Correlates of Cognitive Performance in Late Life

Zhang

Sachdev

Wang

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aim: While a number of studies examined the neuroanatomical correlates of cognitive function in older adults, the results have been inconsistent. Examination of a large epidemiologically acquired sample with high-resolution magnetic resonance imaging has the potential to enhance the evidence in this field. Methods: The participants were 326 non-demented elderly adults undergoing a battery of neuropsychological tests and brain magnetic resonance imaging scans. Regression analyses were performed to examine the correlation between voxel-based grey matter (GM) volume and four cognitive domain scores. Results: Positive correlations were observed between specific GM volumes and cognitive domains, i.e. bilateral temporal lobes and hippocampi with language; bilateral temporal, parietal, and occipital lobes with processing speed; and bilateral frontal, temporal, parietal, and occipital lobes with executive function. The positive correlation between verbal memory performance and GM volume in the bilateral medial temporal lobes was not significant after correction for age. Conclusion: Our findings suggest that the location of GM correlates of cognitive tests is largely consistent with the conventional understanding of the neuroanatomical basis of cognition. However, the lack of hemispheric predominance in these GM correlates, and the extensively positive correlation between GM volume and cognitive performance, perhaps reflects the characteristics of the ageing brain.

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“…English speaking AD patients are reported to overuse pronouns instead of full Noun Phrases (NPs) (Almor, Kempler, MacDonald, Andersen, & Tyler, 1999;Bschor, Kühl, & Reischies, 2001;Kempler & Zelinski, 1994;Nebes, 1989;Ripich & Terrell, 1988), but no consensus exists as to why they do so. Explanations range from locating the deficit in central language processes, either related to working memory (Almor et al, 1999), or impoverished lexical-semantic representations (Altmann, Kempler, & Andersen, 2001;Forbes, Venneri, & Shanks, 2002;Venneri et al, 2008), to attributing this pattern to problems with discourse-pragmatics (Ripich & Terrell, 1988;Ulatowska & Chapman, 1995). In this paper, however, we do not address the nature of the cognitive deficit(s) underlying the lexical problems with NPs in AD.…”

Section: Introductionmentioning

confidence: 99%

Language-specific effects in Alzheimer’s disease: Subject omission in Italian and English

Bencini

Pozzan

Biundo

et al. 2011

Journal of Neurolinguistics

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The anatomical bases of semantic retrieval deficits in early Alzheimer's disease

Cited by 81 publications

References 63 publications

Is Confrontation Naming Performance in Alzheimer’s Disease the Nominal Linguistic Retrogenesis of Normal Development?

Is Confrontation Naming Performance in Alzheimer’s Disease the Nominal Linguistic Retrogenesis of Normal Development?

Neuroanatomical Correlates of Cognitive Performance in Late Life

Language-specific effects in Alzheimer’s disease: Subject omission in Italian and English

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