The Analysis of Patterns and Risk Factors of Newly Developed Vertebral Compression Fractures after Percutaneous Vertebroplasty

Abstract

ObjectiveThe purpose of this study was to investigate the patterns and the risk factors of newly developed vertebral compression fractures (VCFs) after percutaneous vertebroplasty (PVP).MethodsWe performed a retrospective review of the 244 patients treated with PVP from September 2006 to February 2011. Among these patients, we selected 49 patients with newly developed VCFs following PVP as the new VCFs group, and the remaining 195 patients as the no VCFs group. The new VCFs group was further divided into 2 groups : an adjacent fractures group and a nonadjacent fractures group. The following data were collected from the groups : age, gender, body weight/height, body mass index (BMI), bone mineral density (BMD) score of the spine and femur, level of initial fracture, restoration rate of anterior/middle vertebral height, and intradiscal cement leakage, volume of polymethylmethacrylate (PMMA).ResultsAge, gender, mean body height/weight, mean BMI and volume of PMMA of each of the group are not statistically significantly associated with fractures. In comparison between the new VCFs group and the no VCFs group, lower BMD, intradiscal cement leakage and anterior vertebral height restoration were the significant predictive factors of the fracture. In addition, new VCFs occurrence at the adjacent spines was statistically significant, when the initial fracture levels were confined to the thoracolumbar junction, among the subgroups of new VCFs.ConclusionLower spinal BMD, the greater anterior vertebral height restoration rate and intradiscal cement leakage were confirmed as risk factors for newly formed VCFs after PVP.

Analysis of Risk Factors Causing New Symptomatic Vertebral Compression Fractures After Percutaneous Vertebroplasty for Painful Osteoporotic Vertebral Compression Fractures

“…9 Similar to other reported results, 17 the overall incidence of NVCF in our study was 17.2% over 4 years. The risk of NVCF increases yearly as time passes; however, in our study, adjacent fractures mainly occurred within 2 years, whereas remote fractures occurred at a consistent rate every year.…”

“…13,17,20,21 In our study, lower BMD was a risk factor of NVCF as shown by univariate and multivariate analysis and, in particular, a lower BMD is related to the risk of remote fractures (Table 5). In the NVCF group, the average BMD decreased from À 3.29 to À 4.1 compared with the control group (P = 0.55) (Fig.…”

Risk factors for new vertebral compression fractures after vertebroplasty: a meta‐analysis

“…After reviewing the full text of the remaining 26 studies, we excluded nine additional full‐text articles. Finally, 17 unique studies with sufficient data were included and analysed in the meta‐analysis . A flow diagram that shows the literature search process is presented in Figure .…”

“…The descriptive statistics for the studies that were included in our meta‐analysis are summarized in Table . Of the studies, eight were conducted in China, six were conducted in Korea, one was conducted in the Netherlands, one was conducted in Japan and one was conducted in Spain . The results of the quality assessment are summarized as follows: two studies received a score of 9, eight studies received a score of 8, five studies received a score of 7 and two studies received a score of 6.…”

“…To the best of our knowledge, prior studies have investigated many of the risk factors for the development of new VCFs following vertebroplasty, such as low body mass index (BMI), intradiscal cement leakage, high cement volume, low bone mineral density (BMD) and multiple vertebral levels affected . However, these studies were limited by either a small sample size or a limited number of potential risk factors investigated.…”