The Analysis of Depression and Subsequent Cancer Risk in Taiwan

Liang, Ji An; Sun, Li; Muo, Chih Hsin; Sung, Fung Chang; Chang, Shih Ni; Kao, Chia Hung

doi:10.1158/1055-9965.epi-10-1280

Cited by 62 publications

(54 citation statements)

References 8 publications

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“…13 Briefly, the NHI program began in March 1995 and incorporated 13 insurance programs that provided health care to 99% of the Taiwanese population. The program contracted with 97% of the hospitals and clinics on the island, and it provides comprehensive medical services, including outpatient and inpatient care, dental care, physical therapy, preventive care, and prescriptions.…”

Section: For Editorial Comment See Page 417mentioning

confidence: 99%

Relationship of Zolpidem and Cancer Risk: A Taiwanese Population-Based Cohort Study

Kao

Sun

Liang

et al. 2012

Mayo Clinic Proceedings

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Objective: To evaluate the relationship between the use of zolpidem and subsequent cancer risk in Taiwanese patients. Methods: We used data from the National Health Insurance system of Taiwan to investigate whether use of zolpidem was related to cancer risk. For the study cohort, we identified 14,950 patients who had received a first prescription for zolpidem from January 1, 1998, through December 31, 2000. For each zolpidem user, we selected randomly 4 comparison patients without a history of using zolpidem who were frequency-matched by sex, age, and year of the index date. Incidence rates of all cancers and selected site-specific cancers were measured by the end of 2009, and related hazard ratios (HRs) and 95% confidence intervals (CIs) of the cancer were measured as well. Results: The risk of developing any cancer was greater in patients using zolpidem than in nonusers (HR, 1.68; 95% CI, 1.55-1.82). The stratified analysis showed that the overall HR for high-dosage zolpidem (Ն300 mg/y) was 2.38. The site-specific cancer risk was the highest for oral cancer (HR, 2.36; 95% CI, 1.57-3.56), followed by kidney cancer, esophageal cancer, breast cancer, liver cancer, lung cancer, and bladder cancer (HR, 1.60; 95% CI, 1.06-2.41). Men were at higher risk than women. Conclusion: This population-based study revealed some unexpected findings, suggesting that the use of zolpidem may be associated with an increased risk of subsequent cancer. Further large-scale and in-depth investigations in this area are warranted.

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Section: For Editorial Comment See Page 417mentioning

confidence: 99%

Relationship of Zolpidem and Cancer Risk: A Taiwanese Population-Based Cohort Study

Kao

Sun

Liang

et al. 2012

Mayo Clinic Proceedings

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“…Finally, it needs to be considered that all three studies finding negative associations between depression and breast cancer incidence [33,39,43] and six studies finding positive associations [40-42, 44, 47, 48] included fewer than 220 individuals that developed breast cancer, while all studies finding positive associations had numbers of individuals developing breast cancer ranging from 229 to 2,892 cases of breast cancer [38,45,46,[49][50][51]. Thus, the small number of breast cancer cases could be another explanation for the negative associations between depression and breast cancer incidence.…”

Section: Discussionmentioning

confidence: 99%

Depression as a risk factor for breast cancer: investigating methodological limitations in the literature

Pössel

Adams

Valentine

2012

Cancer Causes Control

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“…The Bureau of NHI randomly reviews the records of 1 in 100 ambulatory care visits and 1 in 20 in-patient claims to verify the accuracy of the diagnoses [50]. Several studies have demonstrated the accuracy and validity of the diagnoses in the NHIRD [51,52,53]. …”

Section: Methodsmentioning

confidence: 99%

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

et al. 2016

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Background: Chronic periodontitis and gingivitis are associated with various diseases; however, their impact on dementia is yet to be elucidated. This study is aimed at investigating the association between chronic periodontitis and gingivitis, and the risk of developing dementia. Methods: A total of 2,207 patients, with newly diagnosed chronic periodontitis and gingivitis between January 1, 2000 and December 31, 2000, were selected from the National Health Insurance Research Database of Taiwan, along with 6,621 controls matched for sex and age. After adjusting for confounding factors, Cox proportional hazards analysis was used to compare the risk of developing dementia during the 10-year follow-up period. Results: Of the study subjects, 25 (1.13%) developed dementia compared to 61 (0.92%) in the control group. Cox proportional hazards regression analysis revealed that the study subjects were more likely to develop dementia (hazard ratio (HR) 2.085, 95% CI 1.552-4.156, p < 0.001). After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the HR for dementia was 2.54 (95% CI 1.297-3.352, p = 0.002). Conclusions: Patients with chronic periodontitis and gingivitis have a higher risk of developing dementia. However, further studies on other large or national data sets are required to support the current findings.

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The Analysis of Depression and Subsequent Cancer Risk in Taiwan

Abstract: Background: Patients with depression are suggestive of having a tendency toward a marginally significant association with the subsequent cancer risk. The aim of this study was to evaluate the possible relationship between depression and cancer risk in Taiwan.

Cited by 62 publications

References 8 publications

Relationship of Zolpidem and Cancer Risk: A Taiwanese Population-Based Cohort Study

Relationship of Zolpidem and Cancer Risk: A Taiwanese Population-Based Cohort Study

Depression as a risk factor for breast cancer: investigating methodological limitations in the literature

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

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