The analysis of correlative factors affecting long-term outcomes in patients with Solid Cerebellar Hemangioblastomas

Niu, Liang; Zhang, Yinian; Liao, Qinyu; Dai, Junqiang; Yin, Hang; Duan, Lei; Hu, Yang; Liang, Wentao; Qin, Zhenwei; Zhang, Jianping; Pan, Yawen

doi:10.1016/j.clineuro.2016.08.028

Cited by 16 publications

(8 citation statements)

References 26 publications

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“…For instance, we cannot differentiate between sporadic hemangioblastomas and VHL-related hemangioblastomas within the SEER database, which would have been important in the survival analysis (6,29). In addition, other clinical characteristics including neurological symptoms, preoperative neurological status, and postoperative morbidity were not accessible, which were reported to be associated with patient prognosis (17,30). Furthermore, detailed information regarding surgery including surgical approach, utilization of preoperative embolization, or intraoperative monitoring was not presented.…”

Section: Discussionmentioning

confidence: 99%

“…The extent of tumor resection was classified as follows. Gross total resection was coded as "radical, total, gross resection of tumor, lesion or mass in brain (30) and gross total resection of lobe of brain (55)." Partial resection was coded as "tumor destruction, NOS (10); local excision of tumor, lesion, or mass excisional biopsy (20/21/22), and partial resection of lobe of brain (40)."…”

Section: Data Collectionmentioning

confidence: 99%

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Incidence, Prognostic Factors and Survival for Hemangioblastoma of the Central Nervous System: Analysis Based on the Surveillance, Epidemiology, and End Results Database

Yin

Duan

et al. 2020

Front. Oncol.

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Background: Hemangioblastomas are uncommon, benign neoplasms of the central nervous system (CNS). This study aims to evaluate the incidence, demographics, clinical characteristics, and prognosis of CNS hemangioblastomas using the data from the Surveillance, Epidemiology, and End Results (SEER) Program. Methods: Univariate and multivariate analyses using the Cox proportional hazards model were employed to identify prognostic factors of overall survival. The Kaplan-Meier method was utilized to evaluate overall survival distribution by treatment modality. A nomogram was further built to predict survival at 3 and 5 years. Results: The overall incidence rate of CNS hemangioblastomas was 0.141 per 100,000 person-years. Through univariate analysis and multivariate analyses, age between 60 and 79 years (HR = 3.697, p < 0.001), age greater than 80 years (HR = 12.318, p < 0.001), African American race (HR = 1.857, p = 0.003), multiple tumors (HR = 1.715, p < 0.001), and prior surgery (HR = 0.638, p = 0.013) were significantly associated with overall survival. Patients receiving surgery alone had better overall survival compared with patients receiving no treatment (p = 0.008) and patients receiving both surgery and radiotherapy (p = 0.002). The calibration plots demonstrated an excellent agreement between nomogram-predicted and actual survival. Conclusion: In conclusion, age, race, tumor location, number of tumors, and prior surgery are prognostic factors for survival. Surgery was the most common modality and was suggested as an effective and optimal treatment. The proposed nomogram can predict the prognosis of patients with CNS hemangioblastomas and help clinicians in making decisions.

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Section: Discussionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Incidence, Prognostic Factors and Survival for Hemangioblastoma of the Central Nervous System: Analysis Based on the Surveillance, Epidemiology, and End Results Database

Yin

Duan

et al. 2020

Front. Oncol.

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“…Similarly, pertinent surgical details are not presented. Utilization of preoperative embolization [ 21 , 22 ], tumor consistency [ 1 , 9 , 16 , 23 ], preoperative status [ 10 ], and postoperative morbidity [ 3 , 24 , 25 ] have been associated with poor outcomes in HBs. Moreover, data regarding disease progression are lacking.…”

Section: Discussionmentioning

confidence: 99%

Intracranial hemangioblastoma - A SEER-based analysis 2004–2013

et al. 2018

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IntroductionIntracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.MethodsWith the SEER-18 registry database, information from all patients diagnosed with intracranial HB from 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent of surgery, receipt of radiation, tumor size, tumor location, and follow-up data. Age-adjusted incidence rates and overall survival (OS). Cox proportional hazards model was employed for both univariate and multivariate analyses.ResultsA total of 1307 cases were identified. The overall incidence of intracranial hemangioblastoma is 0.153 per 100,000 person-years [95% confidence interval (CI)=0.145–0.162]. Through univariate analysis, age < 40 [hazard ratio (HR)=0.277, p<0.001], no radiation [HR=0.56, p=0.047], and presence of surgery [HR=0.576, p=0.012] are significant positive prognostic factors. Caucasian race [HR=1.42, p=0.071] and female gender [HR=0.744, p=0.087] exhibit noticeable trends towards positive prognosis. Through multivariate analysis, younger age [HR=1.053, p < 0.01], race [HR=1.916, p<0.01], and presence of surgery [HR=0.463, p<0.01 were significant independent prognostic factors.ConclusionClinical factors such as younger age, Caucasian race, and presence of surgery are significant independent factors for overall survival in patients with HBs. Though analysis regarding extent of surgery did not produce a meaningful relationship, this may be related to surgical bias / expertise. Moreover, no validation for radiation therapy was identified, but this may be related to short follow up intervals and the variable growth patterns of HBs.

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“…Due to its rarity, current literature assessing prognostic factors and survival outcomes of hemangioblastoma is limited 9 , 17 , 23 – 25 . Consequently, the established guidelines for treatment are based on small to medium-sized retrospective studies.…”

Section: Discussionmentioning

confidence: 99%

Assessment of care pattern and outcome in hemangioblastoma

Huang

Chan²,

Bai

et al. 2018

Sci Rep

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Due to its rarity, current literature assessing prognostic factors and survival outcomes of hemangioblastoma is limited. Patients with histologically confirmed hemangioblastoma were identified from the US National Cancer Data Base. 1488 patients met inclusion criteria. 644 patients underwent gross total resection (GTR), 220 subtotal resection (STR)/biopsy, 60 stereotactic radiosurgery (SRS), 15 external beam radiotherapy (EBRT), 51 surgery followed by radiotherapy (SR + RT) and 498 no treatment. Independent predictors of shorter OS included age ≥ 40 (HR, 3.897; 95% CI, 2.341–6.487; p < 0.001), Charlson-Deyo score ≥ 1(HR, 1.756; 95% CI, 1.213–2.544; p = 0.003), tumor location in the brainstem (HR, 1.955; 95% CI, 1.129–3. 384; p = 0.017) compared to cerebellum, no treatment (HR, 2530; 95% CI, 1.533–4.177; p < 0.001) and receipt of EBRT (HR, 2.860; 95% CI, 1.073–7.618; p = 0.036) compared to STR/biopsy. GTR was associated with longer OS (HR 0.617; 95% CI, 0.391–0.974; p = 0.038), while SRS had comparable OS to STR/biopsy. The overall trend of OS by treatment modality was consistent after matching to age- and sex-matched US population data. In patients younger than 40 years, treatment was not a significant predictor of OS. In conclusion, GTR remained the optimal treatment for hemangioblastoma. SRS may perform similarly to surgery alone. Treatment was not a significant predictor of survival in younger patients.

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The analysis of correlative factors affecting long-term outcomes in patients with Solid Cerebellar Hemangioblastomas

Cited by 16 publications

References 26 publications

Incidence, Prognostic Factors and Survival for Hemangioblastoma of the Central Nervous System: Analysis Based on the Surveillance, Epidemiology, and End Results Database

Incidence, Prognostic Factors and Survival for Hemangioblastoma of the Central Nervous System: Analysis Based on the Surveillance, Epidemiology, and End Results Database

Intracranial hemangioblastoma - A SEER-based analysis 2004–2013

Assessment of care pattern and outcome in hemangioblastoma

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