The analysis of circumsporozoite-protein gene sequences from South Korean isolates of<i>Plasmodium vivax</i>

Lim, Chae Seung; Kim, Y. K.; Lee, K. N.; Kim, S. H.; Hoffman, Kenneth J.; Song, Kiwon; Song, Jin Won

doi:10.1080/00034983.2001.11813634

Cited by 16 publications

(21 citation statements)

References 12 publications

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“…Our aim was to determine genetic diversity, which can show whether P. vivax malaria in Korea has become heterogeneous. Genetic studies of P. vivax malaria in Korea have been performed by using several parasitic proteins, including CSP, 17 Duffy-binding protein, 18 apical membrane antigen-1, 19 18S ribosomal RNA, 20 and MSP-1. 9 However, these studies focused on simple polymorphism analysis for each gene over a short period.…”

Section: Discussionmentioning

confidence: 99%

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Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea

Choi¹,

Choi²,

Park³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.

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Section: Discussionmentioning

confidence: 99%

“…We detected four VK210 subtypes (sub-K1-subK4). Another Korean subtype previously reported 17 was included in our study as subK5 ( Figure 4B and Table 2 ). In previous cases of malaria, the major subtypes were sub-K1 (44%) and sub-K3 (56%).…”

Section: Prevalence Of the Reemergedmentioning

confidence: 99%

Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea

Choi¹,

Choi²,

Park³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…PvCSP SKA (or KPVCSP96-6) and SKB (or KPVCSP96-11) alleles from current South Korean isolates are similar to those from Chinese (CH-5) and North Korean isolates, respectively [12][13][14]. CH-5 and North Korean isolates are classified as the East Asian group and the apparent genetic similarities are explained as due to regional proximity [12].…”

Section: Cspmentioning

confidence: 99%

“…CSP is also a prime candidate antigen for vaccines being developed for malaria, and an anti-CSP vaccine has successfully completed Phase III clinical trials [25]. South Korean P. vivax isolates contain unique PvCSP polymorphisms in the CR domain, and in the pre-and post-repeat regions [12][13][14]. Two predominant allelic variants with minor variations in nucleotide sequences in the VK210 genotype have been identified in all South Korean isolates; the nonapeptide sequences are repeated 18 times in South Korean type A (SKA) (or KPVCSP96-6) and 20 times in South Korean type B (SKB) (or KPVCSP96-11) [12][13][14].…”

Section: Cspmentioning

confidence: 99%

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Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax

2009

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The high levels of antigenic polymorphism found in most P. vivax parasites indicate the development of sophisticated evasion of the human immune system [8]. Detailed knowledge of this genetic variation and comparisons of inter-and intra-speciesspecific levels of gene variation will both resolve epidemiological questions about parasite origin and provide tools with which to design an effective vaccine. Polymorphic repetitive sequences, Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivaxKorean J Parasitol. Vol. 47, Supplement: S51-S58, October 2009 DOI: 10.3347/kjp.2009 Abstract: Plasmodium vivax, a protozoan malaria parasite of humans, represents a major public health concern in the Republic of Korea (= South Korea). However, little is known about the genetic properties and population structures of the P. vivax isolates circulating in South Korea. This article reviews known polymorphic genetic markers in South Korean isolates of P. vivax and briefly summarizes the current issues surrounding the gene and population structures of this parasite. The critical genetic characteristics of major antigens of the parasite, such as circumsporozoite protein (CSP), merozoite surface protein 1 (MSP-1) and MSP-3, Duffy binding protein (DBP), apical membrane antigen 1 (AMA-1), and GAM-1, are also discussed.

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Genetic diversity of the malaria vaccine candidate merozoite surface protein 1 gene of Plasmodium vivax field isolates in Republic of Korea

et al. 2011

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The Plasmodium vivax merozoite surface protein 1 (Pvmsp-1) locus codes for a major asexual blood-stage antigen currently proposed as a malaria vaccine candidate antigen. However, extensive polymorphism of this protein has been observed in isolates from different geographical areas. Here, we investigate the extent and the frequency of allelic diversity at the Pvmsp-1 locus in field isolates collected in the Republic of Korea during the past decade. Among the 45 Korean isolates, six Pvmsp-1 gene types (SKOR-I to SKOR-VI) were identified as unique combinations of type sequences in each variable block. Of these six different Pvmsp-1 gene types, two major Pvmsp-1 allelic types were found in 72% (SKOR-I) and 28% (SKOR-II) of field isolates collected in 1996 to 2000, and four different allelic types (SKOR-III to SKOR-VI) emerged in 70% (10-25%) of isolates collected in 2007 to 2009. These results suggest that allelic diversity of Pvmsp-1 increased in several variable regions, including the N- and C-terminals, after reemergence of P. vivax parasites in the Republic of Korea.

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The analysis of circumsporozoite-protein gene sequences from South Korean isolates ofPlasmodium vivax

Cited by 16 publications

References 12 publications

Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea

Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea

Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax

Genetic diversity of the malaria vaccine candidate merozoite surface protein 1 gene of Plasmodium vivax field isolates in Republic of Korea

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