The Analysis of Arterial Stiffness in Heart Failure Patients: The Prognostic Role of Pulse Wave Velocity, Augmentation Index and Stiffness Index

Anastasio, Fabio; Testa, M.; Ferreri, Carla; Rossi, Andrea; Gaetano, Raffaele; Feola, Mauro

doi:10.3390/jcm11123507

Cited by 13 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There have been some reports about prognostic parameters in Group 2 PH, such as PVR, LA stiffness, and BNP level, based on baseline data 15,19,20 . In recent years, increasing efforts have also been made to establish the reliable assessment of provocation testing in order to obtain additional diagnostic data.…”

Section: Discussionmentioning

confidence: 99%

“…There have been some reports about prognostic parameters in Group 2 PH, such as PVR, LA stiffness, and BNP level, based on baseline data. 15 , 19 , 20 In recent years, increasing efforts have also been made to establish the reliable assessment of provocation testing in order to obtain additional diagnostic data. Originally, the NO vasoreactivity test was recommended for patients with Group 1 PH to evaluate pulmonary arterial function or to predict responsiveness to calcium blockers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases

Satoh,

Yaoita,

Nochioka

et al. 2023

ESC Heart Failure

View full text Add to dashboard Cite

AimsThe pathophysiology of pulmonary hypertension (PH) due to left‐sided heart disease (Group 2 PH) is distinct from that of other groups of PH, yet there are still no approved therapies that selectively target pulmonary circulation. The increase in pulmonary capillary pressure due to left‐sided heart disease is a trigger event for physical and biological alterations of the pulmonary circulation, including the nitric oxide (NO)–soluble guanylate cyclase–cyclic guanosine monophosphate axis. This study investigated inhaled NO vasoreactivity tests for patients with Group 2 PH and hypothesized that these changes may have a prognostic impact.Methods and resultsThis was a single‐centre, retrospective study with a median follow‐up of 365 days. From January 2011 to December 2015, we studied 69 patients with Group 2 PH [age, 61.5 ± 13.0 (standard deviation) years; male:female, 49:20; left ventricular ejection fraction, 50.1 ± 20.4%; mean pulmonary arterial pressure, ≥25 mmHg; and pulmonary arterial wedge pressure (PAWP), >15 mmHg]. No adverse events were observed after NO inhalation. Thirty‐four patients with Group 2 PH showed increased PAWP (ΔPAWP: 3.26 ± 2.22 mmHg), while the remaining 35 patients did not (ΔPAWP: −2.11 ± 2.29 mmHg). Multivariate analysis revealed that increased PAWP was the only significant predictor of all‐cause death or hospitalization for heart failure (HF) after 1 year (hazard ratio 4.35; 95% confidence interval, 1.27–14.83; P = 0.019). The acute response of PAWP to NO differed between HF with preserved and reduced ejection fractions.ConclusionsPatients with Group 2 PH were tolerant of the inhaled NO test. NO‐induced PAWP is a novel prognostic indicator.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases

Satoh,

Yaoita,

Nochioka

et al. 2023

ESC Heart Failure

View full text Add to dashboard Cite

show abstract

“…Имеются свидетельства вклада повышенной АР в развитие СН de novo [12], низкую переносимость физических нагрузок при СН, ассоциаций повышения каротидно-феморальной скорости распространения пульсовой волны (кфСРПВ) с сердечной недостаточностью с сохранной фракцией выброса (СНсФВ) [13]. В некоторых исследованиях продемонстрировано повышение параметров АР при СН по сравнению с контрольной группой [14], но изменения жесткости при разных фенотипах фракции выброса (ФВ) изучены недостаточно [15,16]. Работ, посвященных изучению взаимного влияния параметров ригидности и диастолической функции и вклада повышенной жесткости в прогноз у пациентов с СНсФВ немало, хотя результаты их 55,5 %, central PP ≥ 50 mmHg -in 16,6 %, high AS gradient -in 70,3 %.…”

Section: Introductionunclassified

Central blood pressure and arterial stiffness in patients admitted with acute decompensated heart failure

Zenkina,

Troitskaya,

Kobalava

et al. 2024

Arter. gipertenz.

View full text Add to dashboard Cite

Objective. To evaluate central systolic blood pressure (cSBP) and arterial stiffness (AS) in patients admitted with acute decompensated heart failure (ADHF) according to different phenotypes of ejection fraction (EF) and to assess their changes after 6 months of stable guideline-directed medical therapy. Design and methods. In 54 patients (61% males, median age 69,5 (62; 77) years, median EF 51% (interquartile range (IQR) 38; 55%), median N-terminal pro-B-type natriuretic peptide (NTproBNP) 623 (500; 1842) pg/ml; heart failure (HF) with reduced EF in 37%, HF with mildly reduced EF in 13%, HF with preserved EF in 50%), apart from routine tests, we assessed cSBP and AS with applanation tonometry (SphygmoCor). cSBP above individual reference values, central pulse pressure (PP) ≥ 50 mmHg, carotid-femoral pulse wave velocity (cfPWV) > 10 m/s, cfPWV above individual reference values, and aortic-brachial stiffness mismatch (stiffness gradient as cfPWV/carotid-radial (cr)PWV) ≥ 1) were considered abnormal. The statistical analysis was performed in the groups with EF ≥ 50% and < 50% р < 0,05 was considered significant. Results. Brachial systolic blood pressure (bSBP) in the whole group was 117 (106; 130) mmHg; cSBP 109,5 (96; 120) mmHg. Uncontrolled blood pressure was observed in 40%, hypotension — in 3%. There were no differences between groups according to EF. cSBP elevation was observed in 33% (28,5% in EF ≥ 50% and 38,4% in EF < 50%; р > 0,05), and in 27,1% with normal bSBP. There were no significant differences in AS parameters between groups according to EF. Elevation of at least 1 marker of AS was present in 78,5%, cfPWV > 10 ms — in 50%, cfPWV above individual reference values— in 55,5%, central PP ≥ 50 mmHg — in 16,6%, high AS gradient — in 70,3%. Abnormal AS gradient was observed in 48,1% of patients with normal cfPWV. Patients with more severe congestion according to bioimpedance vector analysis (BIVA) had lower cfPWV compared to less severe congestion: 9 (6,7; 10,2) vs 11,6 (6,9; 15,1) m/s, р = 0,04. There was significant correlation between the amount of extracellular fluid by BIVA and cfPWV (r = –0,36, p < 0,05). There was significant increase in cSBP, PP, cfPWV and augmentation index and decrease in PP amplification in the whole group after 6 months. Conclusions. Patients admitted with ADHF have high frequency of cSBP elevation regardless of EF and blood pressure control. The most common marker of AS increase was cfPWV elevation above individual reference values and abnormal stiffness gradient. Patients with less congestion by BIVA had higher cfPWV. After 6 months there was increase in cSBP and parameters of AS.

show abstract

“…Due to the direct relation between PWV and E, PWV is the most commonly measured index of arterial stiffness and is a robust marker for future cardiovascular events (Kim et al 2020, Sequí-Domínguez et al 2020, Kim et al 2022, Marin et al 2022. In medical practice, some serious pathological deviations associated with the state of the vascular walls are diagnosed using measured PWV values, and the dynamics of their development is monitored (Crim et al 2020, Demir et al 2020, Mueller et al 2020, Filip et al 2021, Anastasio et al 2022, Helleputte et al 2022.…”

Section: Introductionmentioning

confidence: 99%

Radial artery pulse wave velocity: a new characterization technique and the instabilities associated with the respiratory phase and breath-holding

Vainer¹

2023

Physiol. Meas.

View full text Add to dashboard Cite

Objective. Pulse wave velocity (PWV) is a key diagnostic parameter of the cardiovascular system state. However, the approaches aimed at the PWV characterization often suffer from inevitable drawbacks. The statistical results demonstrating how closely the PWV in the radial artery (RA) and the respiration phase correlate, as well as the RA PWV evolution during breath-holding (BH), have not been presented in the literature yet. The aims of this study are: a) to propose a simple robust technique for measuring RA PWV, b) to reveal the phase relation between the RA PWV and spontaneous breathing, c) to disclose the BH influence on the RA PWV. Approach. The high-resolution remote breathing monitoring method, Sorption-Enhanced Infrared Thermography (SEIRT), and the described new technique aimed at measuring RA PWV, were used synchronously, and their measurement data were processed simultaneously. Main Results. Spontaneous breathing leaves a synchronous "trace" on the RA PWV. The close linear correlation of the respiration phase and the phase of concomitant RA PWV changes is statistically confirmed in 5 tested persons (Pearson's r is of the order of 0.5-0.8, P<0.05). The BH appreciably affects the RA PWV. A phenomenon showing that the RA PWV is not indifferent to hypoxia is observed for the first time. Significance. The proposed technique for the RA PWV characterization has high prospects in biomedical diagnostics. The presented pilot study deserves attention in the context of mutual respiratory and cardiovascular systems interplay. It may also be useful in cases where the peripheral pulse wave propagation helps assess the respiratory function.

show abstract

The Analysis of Arterial Stiffness in Heart Failure Patients: The Prognostic Role of Pulse Wave Velocity, Augmentation Index and Stiffness Index

Cited by 13 publications

References 32 publications

Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases

Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases

Central blood pressure and arterial stiffness in patients admitted with acute decompensated heart failure

Radial artery pulse wave velocity: a new characterization technique and the instabilities associated with the respiratory phase and breath-holding

Contact Info

Product

Resources

About