The analysis of anxiety and mood in healthy late-reproductive-stage women with regard to hormonal and genetic factors

Jurczak, Anna; Szkup, Małgorzata; Grzywacz, Anna; Safranow, Krzysztof; Grochans, Elżbieta

doi:10.1007/s00737-016-0667-8

Cited by 2 publications

(3 citation statements)

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“…Anxiety, irritability, and mood swings were commonly reported by LRS women in the POAS cohort, but a similar proportion of participants reported these mood symptoms across the MT stages 27 . Women in the West Pomerania Study also reported anxiety and mood disorders during the LRS 8 . A significantly higher proportion of WLB participants in the MT+ group reported low feelings compared to the LRS group.…”

Section: Discussionmentioning

confidence: 82%

“…27 Women in the West Pomerania Study also reported anxiety and mood disorders during the LRS. 8 A significantly higher proportion of WLB participants in the MTþ group reported low feelings compared to the LRS group. Depressed mood symptoms were seen in 50% of women in the premenopausal stage and increased to 60% SYMPTOMS DURING THE LATE REPRODUCTIVE STAGE in the late premenopausal stage for POAS participants.…”

Section: Discussionmentioning

confidence: 88%

“…3 Since 2001, when the STRAW criteria were published, only nine studies focused explicitly on the LRS. Results of these studies suggest that women reported symptoms typically associated with the MT such as sleep disruption, hot flashes, breast pain, vaginal dryness, 4 urinary incontinence and nocturia, 5,6 memory 7 and mood changes, 4,8 and pain 4 before their periods changed significantly.…”

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confidence: 99%

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Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey

2021

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Objective: The aim of this study was to examine the occurrence of a variety of symptoms, their frequency, bother, burden, and interference in the lives of women in the late reproductive stage (LRS) and compare their experiences to that of women in the menopausal transition (MT) stage. Methods: Women ages 35 to 55 years responded to an 82-question online survey offered by Women Living Better. Participants reported current menstrual patterns, recent changes and symptom frequency, bother, and interference. Women's cycles were classified as LRS or MT using Stages of Reproductive Aging Workshop +10 criteria. Results: Of 2,406 respondents, 946 met criteria for LRS and 583 for MT. Participants included 30% from outside the United States, 31% from diverse racial/ethnic groups, and 18% reported having difficulty paying for basics. A similar proportion of women in the LRS and MT+ groups reported each of the symptoms: there was a less than 10% difference for 54 of the 61 symptoms. Of mean bother ratings for all symptoms, only hot flashes differed significantly between the LRS and MT groups. LRS women experienced similar levels of symptom-related interference with personal relationships and daily living to those in the MT stage but did not anticipate these symptoms occurring until they were 50 years old. Conclusions: Women in the LRS experience symptoms strikingly similar to those often associated with the MT. Women do not expect these changes until the age of 50 years or later and are surprised by such symptoms before cycle irregularity. Research about the epidemiology and management of LRS symptoms, anticipatory guidance for women, and education for clinicians who care for them warrant increased attention.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 88%

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confidence: 99%

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Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey

2021

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Transitioning to the menopausal transition: a scoping review of research on the late reproductive stage in reproductive aging

et al. 2021

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Importance and Objective: In 2001 Staging Reproductive Aging Workshop conferees described the late reproductive stage (LRS) of reproductive aging as preceding the onset of the menopausal transition, yet there has been little attention to this aspect of reproductive aging. The aim of this scoping review was to examine scientific publications characterizing the LRS to map what is known about this stage with particular focus on reproductive endocrine patterns, menstrual cycle changes, and symptoms. Methods: The initial search strategy included PubMed and CINAHL searches for the phrase LRS and “human.” Given a low yield of research articles, a second stage used “late reproductive age” (LRA) as a search term. These strategies yielded 9 and 26 research articles, respectively. Publications meeting inclusion criteria (data-based research studies, focus on LRS or LRA and hormonal patterns, menstrual characteristics, and symptoms) published in English were reviewed by coinvestigators. Excluded studies were related to specific diseases, such as cardiovascular disease, and treatment studies. Data were summarized using qualitative methods. To ensure adequate coverage of published research we expanded our review to a third phase in which we identified longitudinal studies of the menopausal transition. Discussion and Conclusions: Studies of the LRS focused on: symptoms (anxiety and mood symptoms, bladder symptoms, urinary incontinence, urinary frequency, and nocturia) and associated factors, such as endocrine levels and gene polymorphisms; symptom clusters women experienced during the LRS; cognitive function testing results; changing patterns of physiology such as cytokines and chemokines, lipids, hormone patterns/levels; and association of lifestyle factors such as smoking with hormone levels and symptoms. The LRA search yielded a preponderance of studies of reproductive hormones (such as anti-Mullerian hormone) and menstrual cycle patterns. Remaining studies focused on symptoms, gene variants, health-related behaviors and approaches to classifying menstrual cycles. Longitudinal studies revealed reports of symptoms as well as attempts to classify the progression from the reproductive years to the menopausal transition. Study of the LRS has not been systematic and the limited number and scope of completed studies have yet to contribute a clear and complete picture of the LRS. In some, LRS provided a comparison stage against which to evaluate menopausal transition hormonal and cycle patterns and symptoms. Harmonizing the results of studies of the LRS and LRA is essential to understand more completely women's experiences of the LRS and to allow clinicians to provide better support for women during this time. The LRS also represents an ideal inflection point to promote lifestyle choices that could alter the trajectories of chronic diseases that arise in the fifth, sixth, and seventh decades of women's lives. Video Summary: http://links.lww.com/MENO/A694.

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The analysis of anxiety and mood in healthy late-reproductive-stage women with regard to hormonal and genetic factors

Cited by 2 publications

References 43 publications

Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey

Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey

Transitioning to the menopausal transition: a scoping review of research on the late reproductive stage in reproductive aging

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