The Analgezic Effect of Vortioxetine on somatic and visceral Pain using the mouse models
Abstract:Experimental investigation of the vortioxetine effects on somatic and visceral nociception in mice. Material and method: We used healthy, non-genetically modified white Swiss mice (20-25 g), randomly assigned in 3 groups of 6 animals each, treated orally 14 consecutive days, as follows: Group I (DW): distilled water 0,1 ml/10 g body weight, Group 2 (VRT): 20 mg/kbw vortioxetine. In the 14 th day of the experiment the Group 3 (KET) received the positive control drug ketoprofen (15 mg/kbw), 15 minutes before the… Show more
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