The Analgestic Effect of Indomethacin in the Early Post-Operative Period Following Abdominal Surgery: A Double-Blind Controlled Study

Thind, Peter; Sigsgaard, T I

doi:10.1016/s0022-5347(17)40702-6

Cited by 3 publications

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“…5 This finding was confirmed by Thind and Sigsgaard. 6 The analgesic effects of rectal indomethaein, cryoanalgesia, and im narcotics for post-thoracotomy pain were compared by Keenan. He found indomethacin to be more effective than cryoanalgesia alone, and when used in conjunction with cryoanalgesia had a synergistic effect on controlling pain on movement.…”

Section: Discussionmentioning

confidence: 99%

Indomethacin as a postoperative analgesic for total hip arthroplasty

Segstro

Morley-Forster

1991

Can J Anaesth

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Section: Discussionmentioning

confidence: 99%

Indomethacin as a postoperative analgesic for total hip arthroplasty

Segstro

Morley-Forster

1991

Can J Anaesth

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“…Indomethacin, a non-steroidal anti-inflammatory drug, is now widely used for its analgesic and anti-inflammatory properties following abdominal surgery, including caesarean section (Engel et al, 1989;Thind & Sigsgaard, 1988). Use of indomethacin in women post-partum for pain relief has led to concern about its possible passage into breast milk and potential adverse effects in young infants.…”

Section: Introduction Methodsmentioning

confidence: 99%

Excretion of indomethacin in breast milk.

Lebedevs,

Wojnar‐Horton,

Yapp

et al. 1991

Brit J Clinical Pharma

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1. The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a daily milk intake of 150 ml kg‐1 and 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) of the weight adjusted maternal dose. 3. Plasma samples were obtained in seven infants. In six of these, indomethacin concentrations were below the sensitivity of the assay (less than 20 micrograms l‐1), while one infant had a plasma indomethacin concentration of 47 micrograms l‐1. 4. No adverse effects due to indomethacin were reported in the infants.

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“…It was concluded that indomethacin was an effective analgesic drug in the early postoperative period (176). In another trial 60 consecutive patients were randomly assigned to have either naproxen 500mg or placebo administered as suppositories half an hour before unilateral herniotomy.…”

Section: Peri-operative Analgesia and Systemic Responsementioning

confidence: 99%

The Randomized Controlled Clinical Trial in Gastroenterology: The Danish Contributions from 1970 to 1994

Lauritsen¹,

Christensen²

1996

Scandinavian Journal of Gastroenterology

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Lauritsen K, Christensen E. The randomized controlled clinical trial in gastroenterology: The Danish contributions from 1970 to 1994. Scand J Gastroenterol 1996;31 Suppl 216:181-98. More than 200 Danish randomized controlled clinical trials in gastroenterology published from 1970 to 1994 were retrieved by electronic media, by hand-searching relevant journals, and by direct requests to Danish gastroenterologists. With the historical perspective through a quarter of a century, these papers are outlined to provide a survey of the pieces of information that Danish gastroenterologists have contributed to the present knowledge of therapeutics. The presented randomized controlled clinical trials constitute an impressive sum of knowledge within a diversity of topics. A cautious analysis of the time pattern for the publications in addition to the contents of the reports discloses that the discipline of planning and executing relevant controlled clinical trials is now in blossom in Danish gastroenterology. Denmark Ifax: +45 65 91 74 81) Scand J Gastroenterol Downloaded from informahealthcare.com by Mcgill University on 12/09/14 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by Mcgill University on 12/09/14 For personal use only.

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The Analgestic Effect of Indomethacin in the Early Post-Operative Period Following Abdominal Surgery: A Double-Blind Controlled Study

Cited by 3 publications

References 0 publications

Indomethacin as a postoperative analgesic for total hip arthroplasty

Indomethacin as a postoperative analgesic for total hip arthroplasty

Excretion of indomethacin in breast milk.

The Randomized Controlled Clinical Trial in Gastroenterology: The Danish Contributions from 1970 to 1994

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