2013
DOI: 10.1111/anae.12495
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The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study

Abstract: SummaryKetamine and pregabalin each provide postoperative analgesia, although the combination has yet to be evaluated. One hundred and forty-two patients undergoing total hip arthroplasty were randomly assigned to receive ketamine alone, pregabalin alone, ketamine and pregabalin combined, or placebo. Pain scores at rest and on movement, morphine consumption, side-effects, pressure pain thresholds and secondary hyperalgesia were evaluated. Mean (SD) total 48-h morphine use was reduced in patients given ketamine… Show more

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Cited by 54 publications
(49 citation statements)
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“…Thus far, a host of animal studies have found that OIH is reversible by the NMDA receptor antagonists MK-801 [31,42,[160][161][162][163][164][165], ketamine, or traxoprodil [93]. Human studies have found similar results by adding adjuvant ketamine [46,54,88,166], as well as gabapentinoids such as pregabalin [49,55] or gabapentin [23], or the cyclooxygenase-2 inhibitor parecoxib [48,167], as reviewed in the subsequent sections. However, more recent research has shown that manipulating these substrates does not unequivocally resolve OIH.…”
Section: Prospective Treatments For Oihmentioning
confidence: 96%
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“…Thus far, a host of animal studies have found that OIH is reversible by the NMDA receptor antagonists MK-801 [31,42,[160][161][162][163][164][165], ketamine, or traxoprodil [93]. Human studies have found similar results by adding adjuvant ketamine [46,54,88,166], as well as gabapentinoids such as pregabalin [49,55] or gabapentin [23], or the cyclooxygenase-2 inhibitor parecoxib [48,167], as reviewed in the subsequent sections. However, more recent research has shown that manipulating these substrates does not unequivocally resolve OIH.…”
Section: Prospective Treatments For Oihmentioning
confidence: 96%
“…Ackerman [40] described a similar outcome in 28 % of a sample of 197 patients with chronic pain receiving opioids. While some studies suggest that OIH develops after chronic opioid use [41][42][43], both rodent [44,45] and human studies [46][47][48][49] have documented OIH within hours of acute opioid administration. Studies using shorter-acting opioids such as remifentanil, sufentanil, fentanyl, and morphine provide the most suspicion of OIH [49][50][51][52][53][54][55][56]; however, there is documentation of this phenomenon in patients receiving long-acting opioids (e.g., methadone or buprenorphine) as well [23,43,[57][58][59][60].…”
Section: Prevalence Of Oih In Humansmentioning
confidence: 99%
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“…Supplementary 18,[20][21][22][25][26][27]29,30,32,34,36,40,41,44,45,50 cardiac or thoracic surgery (six trials), 19,23,35,37,38,53 orthopedic surgery (ten trials), 24,28,31,33,39,43,[47][48][49]51 and other surgery (three trials). 42,46,52 General anesthesia was used in 34 trials; one trial used PCA during and after a uterine artery embolization procedure, 29 and one used either general or regional anesthesia.…”
Section: Characteristics Of Included Studiesmentioning
confidence: 99%
“…2 Recent examples of randomised controlled trials (RCTs) demonstrating the additional benefits of double combinations of nonopioid analgesics include a dexamethasone/ pregabalin combination for pain after tonsillectomy 8 and a pregabalin/ketamine combination for pain after hip arthroplasty. 9 Narrative reviews on postoperative multimodal analgesia often mention over half a dozen different classes of nonopioid agents [e.g. acetaminophen, NSAIDs, N-methyl-D-aspartate receptor (NMDA) antagonists, gabapentinoids, alpha-2 adrenergic agonists, systemic local anaesthetics and cannabinoids], 10,11 but as yet, no RCTs have rigorously evaluated the added benefit of combining more than two nonopioids for postoperative pain.…”
Section: Introductionmentioning
confidence: 99%