The analgesic efficacy of tenoxicam versus placebo in day case laparoscopy: a randomised parallel double‐blind trial

Windsor, Alastair; McDonald, Patricia E.; Mumtaz, Tayebah; Millar, J.M.

doi:10.1111/j.1365-2044.1996.tb15008.x

Cited by 22 publications

(10 citation statements)

References 14 publications

(1 reference statement)

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“…4 Other studies addressing the analgesic effect of NSAIDs in gynecological procedures have failed to demonstrate a significant reduction in either postoperative pain or the need for additional opioids. [8][9][10][11][12][13][14][15][16][17][18] Our pilot study and previous reports do not, however, support the equipotency of tramadol and indomethacin which may represent a limitation of our study. Tramadol is an effective analgesic which causes less respiratory depression than morphine.…”

Section: Discussioncontrasting

confidence: 75%

Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy

Khazin¹,

Weitzman²,

Rozenzvit-Podles³

et al. 2011

International Journal of Obstetric Anesthesia

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Section: Discussioncontrasting

confidence: 75%

Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy

Khazin¹,

Weitzman²,

Rozenzvit-Podles³

et al. 2011

International Journal of Obstetric Anesthesia

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“…This property may be useful in major gynaecological surgery because of the associated propensity for thromboembolic phenomena 6 , providing that clinical haemostasis is not disturbed. Tenoxicam has been well studied in the treatment of rheumatic disorders 7 but there have been relatively few descriptions of its disposition after major surgery or use in the treatment of postoperative pain [8][9][10][11] .…”

mentioning

confidence: 99%

Tenoxicam IV in Major Gynaecological Surgery— Pharmacokinetic, Pain Relief and Haematological Effects

Jones

Miles

Prankerd

et al. 2000

Anaesth Intensive Care

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This study compared postoperative analgesic dispensation and measures relating to haemostasis following intravenous administration, in a randomized double-blinded manner, of either placebo or tenoxicam 20 mg to 30 women presenting for major gynaecological oncology surgery under a standardized, combined epidural/general anaesthetic technique. Pharmacokinetic disposition of tenoxicam in this patient cohort was also described. There was no objective or subjective alteration in haemostatic function or increase in blood loss, nor any deviation from the normal range of values. Postoperative analgesia during the first 48 hours was delivered to achieve a VAS endpoint of less than five on leg-raising, by a combination of a nurse-controlled low-dose background epidural infusion and patient-administered epidural bolus. Greater VAS variability was observed during the first four postoperative hours (P=0.08). The tenoxicam group self-administered significantly fewer epidural bolus doses to maintain satisfactory analgesia compared with the placebo group during the first 24 hours (P=0.004) and 48 hours (P=0.01) postoperatively. Similar differences between the groups in the total dose of the epidural bupivacaine/fentanyl mixture delivered were described (4 h: P=0.148; 24 h: P=0.033; 48 h: P=0.001) (Figure 2). Despite surgery, transfusion and the use of a renal protective fluid administration strategy, tenoxicam disposition was not greatly different from that widely described for healthy volunteers. There were no significant side-effects and no adverse events attributable to tenoxicam. In this small study we have shown that tenoxicam administered preoperatively reduced the epidural analgesic requirements during the first 48 hours following major gynaecological surgery. There was no clinical or pathological evidence of haematological impairment following a single IV administration of tenoxicam 20 mg.

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“…Giving tenoxicam either before skin incision (5, 6) or on skin closure (8–10) improves its analgesic effect compared to giving it after emergence from anesthesia. Colbert and colleagues found that, for ambulatory breast biopsy, tenoxicam 20 mg, IV, given preincisionally, provided better pain relief than when given later, and suggested that timing was important in obtaining the pre‐emptive effect (5).…”

Section: Discussionmentioning

confidence: 99%

“…With institutional approval and written informed consent, 88 ASA physical status I or II patients scheduled for elective LC were included and randomly divided into four groups. Based on our previous studies, we used a dose of 40 mg of DM containing 20 mg of chorpheniramine (CPM) (1–4) and 40 mg tenoxicam IV (8–10). The control group (C) received 20 mg of CPM (IM) injection and 4 ml of normal saline (N/S) IV, as in our domestic market, one ampoule of DM (10 mg) contains 5 mg of CPM.…”

Section: Methodsmentioning

confidence: 99%

Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy

Yeh¹,

Wu²,

Lee

et al. 2004

Acta Anaesthesiol Scand

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The analgesic efficacy of tenoxicam versus placebo in day case laparoscopy: a randomised parallel double‐blind trial

Abstract: SummaryThe

Cited by 22 publications

References 14 publications

Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy

Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy

Tenoxicam IV in Major Gynaecological Surgery— Pharmacokinetic, Pain Relief and Haematological Effects

Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy

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