The Analgesic Effects of the Addition of Intravenous Ibuprofen to a Multimodal Analgesia Regimen for Pain Management After Pediatric Cardiac Surgery: A Randomized Controlled Study

The Year in Review: Anesthesia for Congenital Heart Disease 2022

“…In a study of the opioid-sparing effects of ibuprofen, Abdelbaser et al prospectively compared 34 children receiving scheduled intravenous ibuprofen after cardiac surgery to 34 children who did not receive ibuprofen. 20 Mean fentanyl consumption was significantly lower in the first 24 hours post-extubation in the ibuprofen group (3.5 μg/kg vs 5.1 μg/kg, P < .001), and mean pain scores at 24 hours were significantly lower in the ibuprofen group (1.5 vs 2.5, P < .005). No side effects attributable to ibuprofen were noted.…”

The Year 2022 in Review and a Glimpse into the Future

“…31,32 In addition to the effects of regional anesthesia, there was evaluation of sedation and perioperative analgesic practices, which showed a welcome reduction in fentanyl consumption with the addition of scheduled Ibuprofen and importantly no increase in bleeding or kidney injury. 33 Goodmanson et al also engage in an excellent discussion of DEI topics and the intersection with outcomes and treatment disparities, concluding that there continued to be disparities in outcomes and treatment received among certain populations. In pediatric cardiac surgery, race seemed to transcend age and have an influence on poorer outcomes.…”

“…31,32 In addition to the effects of regional anesthesia, there was evaluation of sedation and perioperative analgesic practices, which showed a welcome reduction in fentanyl consumption with the addition of scheduled Ibuprofen and importantly no increase in bleeding or kidney injury. 33…”

Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut

“…40 Efikasi dan keamanan ibuprofen IV pada anak juga telah ditunjukkan dalam beberapa uji klinik. [41][42][43] Penambahan ibuprofen IV 10 mg/kgBB/6 jam selama 24 jam ke rejimen analgesia multimodal untuk manajemen nyeri pasca-operasi jantung pediatrik terbukti aman dan efektif mengurangi konsumsi opioid dan skor nyeri. 42 Ibuprofen IV 10 mg/kgBB diinfus selama 15 menit intraoperatif setelah induksi anestesi secara signifikan mengurangi kejadian agitasi darurat/emergence agitation pasca-anestesi umum pada anak.…”

“…[41][42][43] Penambahan ibuprofen IV 10 mg/kgBB/6 jam selama 24 jam ke rejimen analgesia multimodal untuk manajemen nyeri pasca-operasi jantung pediatrik terbukti aman dan efektif mengurangi konsumsi opioid dan skor nyeri. 42 Ibuprofen IV 10 mg/kgBB diinfus selama 15 menit intraoperatif setelah induksi anestesi secara signifikan mengurangi kejadian agitasi darurat/emergence agitation pasca-anestesi umum pada anak. 43 Pemberian ibuprofen IV dengan dosis 400 dan 800 mg setiap 6 jam pasca-operasi bersama morphine IV secara PCA menghasilkan analgesia yang lebih baik, tetapi hanya dosis 800 mg yang menunjukkan efek opioid sparing.…”