The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation–Induced Visceral Hyperalgesia in Rats

Paeoniflorin ameliorates ischemic neuronal damage in vitro via adenosine A1 receptor-mediated transactivation of epidermal growth factor receptor

“…PF has many biological activities and has been shown to be anti-inflammatory [2][3][4] , analgesic [5] , and an antioxidant [6,7] . Furthermore, PF is a potential neuroprotective agent.…”

Evaluation of the analgesic activities of the crude aqueous extract and fractions of Shao Fu Zhu Yu decoction

“…In this study our results showed that the SFD-40% fraction significantly reduces PGE 2 and NO accumulation in LPS-treated macrophage cells, suggesting that this fraction may induce peripheral analgesia partly by inhibiting PG production. In addition, we identified several chemical components from the SFD-40% fraction by UPLC-MS, including paeoniflorin, ferulic acid, typhaneoside, isorhamnetin-3-O-neohesperidoside, senkyunolide I and senkyunolide H. Paeoniflorin, a major component with 12% content (w/w) in the SFD-40% fraction, has analgesic effects (Zhang et al, 2008); recently it has been reported to inhibit COX-2 expression and activity in LPS-stimulated RAW264.7 (Sun et al, 2009), and could also inhibit the L-type Ca 2+ current and Ca 2+ influx in neuronal cells (Tsai et al, 2005). However, it is currently unknown whether isorhamnetin-3-O-neohesperidoside and typhaneoside, the other two compounds with a content of 2.98% and 2% (w/w), respectively, in the SFD-40% fraction, play a role in inhibition of COX-2 or Ca 2+ influx.…”

“…It has been demonstrated that the active herbs in the SFD formula have a wide range of biological activities, including anti-inflammatory, analgesic, antioxidant, immunomodulatory, and anticoagulant activities (Chien et al, 2008;Zhang et al, 2008;Du et al, 2007;Lantz et al, 2007;Tognolini et al, 2006). However, there are few reports on the pharmacological actions and active components of whole-formula SFD related to primary dysmenorrhea.…”

Phytochemical and Biological Studies of Paeoniaceae

“…Paeoniflorin (1) has an analgesic effect on neonatal maternal separation-induced visceral hyperalgesia in rats. This effect may be mediated by k-opioid receptors and a2-adrenoreceptors in the central nervous system [185]. There is evidence showing that 1 could also produce analgesia against various phenotypes of nociception and hypersensitivity [186].…”

“…is a rich source of paeonol (185), paeoniflorin (1), and their analogs, which are established as the main constituents accounting for most of the reported biological activities. Paeonol (185), paeoniflorin (1), and the mixture of all glucosides of peony have already been established as new drugs. Also, 117 is being developed into a medicinal form for treatment of cancer and diabetes.…”