The Analgesic Effect of Fentanyl, Morphine, Meperidine, and Lidocaine in the Peripheral Veins

Pang, Wei‐Wu; Mok, Martin S.; Huang, Shyuan; Hwang, Mina

doi:10.1097/00000539-199802000-00031

Cited by 42 publications

(32 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In our study, the overall incidence of pain during i.v. injection of propofol in the lidocaine group was 8% and it was similar to the results of Pang and colleagues 12 who reported it to be 11%. But, in some other studies higher incidences, such as 18% 13 or 42%, 11 have been reported.…”

Section: Discussionsupporting

confidence: 88%

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Canbay

Çelebi

Arun

et al. 2008

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Canbay

Çelebi

Arun

et al. 2008

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Delayed pain has a latency of between 10 -20 secs. (6) Up to now, the mechanism of pain due to propofol injection has been unclear. Propofol belong to the group of phenols and can directly irritate the skin, mucous membrane and venous intima and could immediately stimulate nociceptors and free nerve endings.…”

Section: Resultsmentioning

confidence: 99%

“…Pang et al showed that tramadol has local anaesthetics effects. 6 Hamid Zahedi et al evaluated that tramadol and ondansetron significantly reduced the incidence and severity of propofol injection pain. 19 In this study, we observed a high incidence of pain in 85% of patients in saline group during propofol injection which was decreased to 12.5% and 20% after tramadol and ondansetron pre-treatment respectively.…”

Section: Discussionmentioning

confidence: 99%

A Study of Comparison Between Tramadol and Ondansetron to Alleviate Pain During Propofol Administration

Manzoor¹,

Malla²,

Sof³

et al. 2018

jemds

View full text Add to dashboard Cite

BACKGROUND Propofol is a commonly used anaesthetic agent for induction and maintenance of anaesthesia. Its intravenous administration is associated with pain, which is reduced by different pharmacological methods. Our study evaluated comparative effectiveness of ondansetron and tramadol in reducing this pain. MATERIALS AND METHODSAfter approval by the Institutional Ethical Committee and an informed written consent, 120 American Society of Anaesthesiologist (ASA) Grade I and II patients of either sex, aged 18 -60 years, undergoing various surgeries using general anaesthesia were selected. Patients with known hypersensitivity to propofol, ondansetron and tramadol, cardiac conduction defects and epilepsy were excluded. In our study, patients were randomly assigned to three groups of 40 patients each (Group 1, n= 40): Patients received upto 2 mL pre-treatment 50 mg tramadol in the saline, (Group 2, n= 40): 4 mg ondansetron in the saline (2 mL), (Group 3, n= 40): normal saline 2 mL. Drugs were given intravenously for a period of 10 seconds, while the venous drainage was occluded by placing an air-filled tourniquet (pressure inflated to 70 mmHg) on the upper arm by an assistant for one minute. Then patient was given intravenous propofol (1%) 2 mg/kg over a period of 10 seconds. The patient was asked a standard question "Is the injection comfortable?" The verbal response and behavioural signs such as facial grimacing, arms withdrawal or tears were recorded. A score of 0 to 3 corresponding to 0= No pain, 1= Mild pain, 2= Moderate pain and 3= Severe pain will be noted. RESULTSThe overall incidence of pain was 85% in the saline group, which was decreased to 12.5% and 20% after tramadol and ondansetron pre-treatment respectively. Pain severity was significantly less in patients receiving drugs for pre-treatment than those receiving saline (p < 0.0001). No significant association was found between gender and incidence and severity of pain (p= 0.70). The incidence and severity of pain in patients above 50 years old was significantly less than patients below 50 years old (0.0001). CONCLUSIONTramadol and ondansetron pre-treatment provides a simple and safe method of reducing propofol injection pain. Both are equally effective, but ondansetron has an advantage in preventing postoperative nausea and vomiting. KEYWORDS Propofol, Ondansetron, Tourniquet. HOW TO CITE THIS ARTICLE: Manzoor S, Malla MS, Sofi AA, et al. A study of comparison between tramadol and ondansetron to alleviate pain during propofol administration. J. Evolution Med. Dent. Sci. 2018;7(02):242-245, DOI: 10.14260/jemds/2018/54 BACKGROUND Propofol is a popular anaesthetic intravenous agent, especially for brief cases, day surgery or when laryngeal mask airway is to be used. Propofol can also be used in total intravenous anaesthesia (TIVA) technique for the maintenance of anaesthesia and sedation. It has also been used for the prevention of emesis. (1) Tracheal intubation without neuromuscular blocking agents (2) and the treatment of pruritus. (3,4) Propof...

show abstract

“…Several methods for prevention of pain have been tried with varying degrees of success like addition of lignocaine, [2,3,9] cooling [10,11] or warming [12] of the drug, diluting propofol solution [5,13], pretreatment with ondansetron [14], metoclopramide [15], opioids [16], thiopentone [17], paracetamol [18], dexamethasone [19] and dexmedetomidine [20]. Analgesic effect of lignocaine may occur because of a local anesthetic effect or an inhibitory effect on the enzymatic cascade which leads to release of kinins [3].…”

Section: Discussionmentioning

confidence: 99%

Role of Steroids in Prevention of Pain on Propofol Injection

Yadav¹,

Durga²,

Gopinath³

2011

J Anesthe Clinic Res

View full text Add to dashboard Cite

Background and objectives: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol. Methods:A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to ASA physical status I or II, scheduled to undergo elective surgery. They were randomly assigned into lignocaine, 10mg/2ml hydrocortisone and 25mg/2ml hydrocortisone respectively as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale. Results:The four groups were comparable in respect to patient's characteristics. There was no significant difference of haemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other 3 groups. Conclusion:Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection.four groups of 18 each. Group NS, group LG, group HC10, and group HC25, received 2ml normal saline, 2ml 2%

show abstract

The Analgesic Effect of Fentanyl, Morphine, Meperidine, and Lidocaine in the Peripheral Veins

Cited by 42 publications

References 20 publications

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

A Study of Comparison Between Tramadol and Ondansetron to Alleviate Pain During Propofol Administration

Role of Steroids in Prevention of Pain on Propofol Injection

Contact Info

Product

Resources

About