The analgesic and sedative effects of intrathecal midazolam in perianal surgery

Abstract

The use of intrathecal midazolam combined with intrathecal bupivacaine produces a more effective and longer analgesia with a mild sedative effect in perianal surgery.

Intrathecal Midazolam as an Adjuvant in Pregnancy-Induced Hypertensive Patients Undergoing an Elective Caesarean Section: A Clinical Comparative Study

“…Similar observations have been reported by other studies (33,34). Further investigations have shown that the addition of midazolam or fentanyl to intrathecal bupivacaine does not alter the peak level of the sensory block (9,35,36).…”

Efficacy of intrathecal midazolam versus fentanyl for endoscopic urology surgery

“…Others also observed that intrathecal midazolam produced significant postoperative pain relief in patients undergoing lower abdominal and perineal surgeries. 12,13,15,17 Midazolam produces spinally mediated analgesia that is different in quality from that produced by the μ-opioid agonist fentanyl. The analgesic effects of intrathecal midazolam have been proposed to be due to its intrathecal spinal receptor interactions affecting the type A gamma-aminobutyric acid receptors.…”

“…[6][7][8][9][10] Previous reports have shown that administration of intrathecal midazolam with local anesthetics prolongs the duration of spinal anesthesia and produces longer postoperative analgesia after lower abdominal and perianal surgeries. [11][12][13][14][15][16][17] None of these studies reported any serious adverse effects in patients receiving intrathecal midazolam. A large cohort study investigating the adverse neurological effects of intrathecal midazolam has also found no association between intrathecal midazolam and neurologic symptoms.…”

Evaluation of Addition of Low Dose Midazolam to a Mixture of Low Dose Ketamine and Hyperbaric Bupivacaine Given in Subarachnoid Block in Patients Undergoing Lower Limb Orthopaedic Surgery

“…Our result in this regard is in resemblance to the study of T M Krishna (2008). Yegin et al (2004) also reported sedative scales were significantly higher in bupivacaine plus midazolam group compared to bupivacaine alone group. However, N Bharti et al (2003) and Mi Ja Yun et al (2007) reported that the sedative score were comparable in both groups.…”