The Analgesic and Anxiolytic Activity of Resveratrol Mediated by Different Sub-Types of α-Adrenoceptors of Anterior Cingulate Cortex Following Neuropathic Pain in Male Rats

Mirasheh, Mohammad Hassan; Zohrehvand, Mohammad Reza; Kazemi, Reza; Bahari, Zahra; Bahrami, Fariba; Jangravi, Zohreh; Graily, Mehdi

doi:10.30699/jambs.28.129.183

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…Behavioral testing to detect signs of cold allodynia was carried out in all rats; all three groups were present in this study on two occasions: days 3 and 6 after the CCI operation. Half an hour was given for adaptation and after that put the rat in the allodynia assessment box and then pulled acetone into the syringe and every 3 minutes with the speed by pressing the syringe towards the sole of the rat's foot, empty five times every 3 minutes and we take the hind paw withdrawal as a variable 26 .…”

Section: Methodsmentioning

confidence: 99%

“…The number of the open and closed arm of EPM entries and the time each animal spent on the open and closed arm of EPM were recorded by the camera and later analyzed. An open arm of EPM entry was defined as all four paws on an open arm of the EPM 26 - 28 . The timetable of interventions performed in the study groups has been shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…The [26][27][28] . The timetable of interventions performed in the study groups has been shown in Figure 1.…”

Section: Elevated Plus Mazementioning

confidence: 99%

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The effects of Valerian on sleep spindles in a model of neuropathic pain

Soltani¹,

Bahrami²,

Bahari³

et al. 2021

Sleep Sci

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Introduction:Valeriana officinalis is known to be one of the most famous herbal supplements for the treatment of anxiety and insomnia. Despite its widespread use in most countries all around the world, there is little scientific information and research on how this medication affects sleep patterns, and there are almost no studies on its effects on the characteristics of sleep spindles. Material and Methods: The present study was conducted to investigate the effects of Valerian extract (VAL) on sleep spindles and induced anxiety in chronic neuropathic pain model in rats. 24 male rats were divided into three groups: neuropathic group (n=9) in which the rats underwent chronic constriction injury (CCI), sham group (n=7) in which the sciatic nerves of the animals were exposed without any constriction and also fed with the vehicle, and the third group was under CCI condition and treated with Valerian (n=8). All the rats underwent electrode implant surgery so that we could record electroencephalogram and electromyography waves. In all the three groups, EEG and EMG recordings were recorded three times (150min each time). The initial recording was just prior to the CCI surgery and the rest were 3 and 6 days following CCI surgery. Moreover, cold allodynia and elevated plus maze tests were performed 3 and 6 days following the CCI surgery. Results: Valerian treatment could repair the allodynia induced by neuropathy. On the other hand, by Valerian treatment (400mg/kg) during neuropathy, the REM sleep, decreased and the non-REM sleep increased. Moreover, there was an increment in sleep spindle density and spindle frequency even in neuropathic condition. Discussion: This herbal supplement improves the quality of sleep in neuropathy conditions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The effects of Valerian on sleep spindles in a model of neuropathic pain

Soltani¹,

Bahrami²,

Bahari³

et al. 2021

Sleep Sci

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“…To assess cold allodynia in neuropathic rats, foot withdrawal (as a positive response) in response to acetone drop (acetone test) was evaluated [17]. Brie y, the rat was placed under a transparent Plexiglas chamber with a metal mesh oor.…”

Section: Cold Allodynia (Acetone Test)mentioning

confidence: 99%

Analgesic effects of Terminalia Chebula is mediated by suppression of brain protein expression of NGF and NF-κB and oxidative markers following neuropathic pain in rats

Haghani

Jaafari

Meftahi

et al. 2022

Preprint

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Background: Due to the complications related to the use of the current pharmacological approach for relief of neuropathic pain, searching for effective compound with less complication is need of present era. Since, the pathophysiology mechanism of neuropathic pain is related to excessive inflammation in nervous system. Hence, the present study focuses on whether the potential analgesic effects of Terminalia Chebula (TC) extract is mediated by the changes of brain protein expression of nerve growth factor (NGF) and nuclear factor-kappa B (NF-κB) in a rat model of sciatic nerve chronic constriction injury (CCI).Method and Results: Neuropathic pain induced by left sciatic nerve CCI. Male wistar rats assigned into sham, CCI, and CCI+TC (40mg/kg) groups. Animals received normal saline (1 ml) or aqueous-alcoholic extract of TC (40 mg/kg) for 30 days via gavage needles once a day. Cold allodynia and anxiety-like behaviors examined on one day before CCI surgery (day -1) and also on days 2, 7, 14 and 30 following CCI. We also assessed TC extract effects on oxidative stress markers on day 30 following CCI. Furthermore, western blot study performed on day 30 following CCI for evaluation of TC extract effects on protein expression of NGF and NF-κB of the brain. Orally gavage of TC extract significantly decreased cold allodynia on days 2 and 14 following CCI. Additionally, CCI model of chronic pain significantly increased protein expression of NGF and NF-κB of the brain on day 30 following CCI. Furthermore, TC extract significantly decreased protein expression of NGF and NF-κB of the brain. The TC extract significantly increased brain glutathione (GSH) content and decreased malondialdehyde (MDA) content. Conclusions: It is suggested that analgesic effects of TC extract is mediated by suppression of brain NGF, NF-κB, and also its antioxidant activity in the brain following neuropathic pain in rats.

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