The Analgesic Actions of Analgesics, Antihistaminics and Chlorpromazine in Volunteers

Hougs, Willy

doi:10.1111/j.1399-6576.1959.tb00038.x

Cited by 2 publications

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“…These authors concluded that the effect of antihistamines on morphine analgesia was not through an antihistaminic action. It has been reported that several antihistamines have an analgesic effect upon thermal pain (Hoags & Skouby, 1957) and that this analgesic action did not correlate to the antihistaminic or sedative properties of these drugs.…”

Section: Discussionmentioning

confidence: 98%

“…Mattila & Saarnivaara (1968), while investigating the effect of some antihistamines on the antinociceptive action of morphine in the rabbit tooth pulp test found that there was a relationship between the ability of these drugs to enhance the antinociceptive action of morphine and the sedative effect of antihistamines. However, a clinical report indicates that some antihistamines themselves relieve thermal pain in man (Hoags & Skouby, 1957) and in the laboratory the phenylquinone writhing test always gives a positive reaction to antihistamines (Hendershot & Forsaith, 1959).…”

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confidence: 99%

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Effects of Morphine on Brain Histamine, Antinociception and Activity in Mice

Lee

Fennessy

1976

Clin Exp Pharmacol Physiol

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1. The effect of morphine on the histamine content of the mouse brain has been investigated. The changes in the brain histamine level have been related to morphine-induced analgesia and morphine-induced changes in locomotor activity. 2. With doses of morphine between 1 and 5 mg/kg there was a significant increase in histamine levels. The time required to produce a maximal rise in the brain histamine level with 5 mg/kg of morphine was 15 min. 3. There was a significant decrease in brain histamine levels with doses of morphine between 7-5 and 100 mg/kg. The time at which the greatest decrease was produced with 50 mg/kg was 30 min. 4. The time couse of the alteration of brain histamine by morphine did not correlate with its antinociceptive activity. Both the 5 and 50 mg/kg doses of morphine produced analgesia in mice whereas brain histamine levels were increased and decreased, respectively. 5. Pretreating mice with compounds which modify histaminergic function did not modify the antinociceptive action of morphine. 6. Morphine produced a biphasic effect on locomotor activity when the dose was increased from 0-5 through to 100 mg/kg. Doses up to 2-5 mg/kg caused a reduction of activity and doses above this produced significant increases. 7. There appears to be an inverse relationship between the morphine-induced changes of brain histamine and the morphine-induced changes in locomotor activity.

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Section: Discussionmentioning

confidence: 98%

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confidence: 99%

Effects of Morphine on Brain Histamine, Antinociception and Activity in Mice

Lee

Fennessy

1976

Clin Exp Pharmacol Physiol

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“…Several early studies found an analgesic effect, or an enhancement of opioid‐induced analgesia, was produced by antihistamines in human volunteers (31) or in patients (32, 33). However, other studies did not, even using the apparently same clinical models and assessment measures (34).…”

Section: Antihistaminesmentioning

confidence: 99%

Antihistamines as analgesics

Raffa

2001

J Clin Pharm Ther

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Histamine activates pain-transmitting nerve fibres, releases pain-related neuropeptides, and is painful when injected into the skin. Histamine agonists mimic these effects, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus. Certain 'antihistamines' (histamine H1 receptor antagonists) and other antihistaminics are 'analgesic' in preclinical or clinical models. Potential sites of action of these agents include the brain and spinal cord and a specific histamine receptor subtype might be involved (three subtypes have been identified). However, it is possible that other mechanisms account for the analgesic effect.

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The Analgesic Actions of Analgesics, Antihistaminics and Chlorpromazine in Volunteers

Cited by 2 publications

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Effects of Morphine on Brain Histamine, Antinociception and Activity in Mice

Effects of Morphine on Brain Histamine, Antinociception and Activity in Mice

Antihistamines as analgesics

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