The ANACONDA algorithm for deformable image registration in radiotherapy

Weistrand, Ola; Svensson, Stina

doi:10.1118/1.4894702

Cited by 224 publications

(232 citation statements)

References 62 publications

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“…Although the deformable registration algorithm was validated previously for pelvic registrations [21], we validated our registrations by visual inspection and OAR similarity quantification to ensure plausible dose warping. However, an extensive validation of the complete anatomical correctness and the influence of possible incorrectness on dose accumulation is still an important challenge in RT [25] and beyond the scope of this study.…”

Section: Discussionmentioning

confidence: 99%

“…The toxicity-related DVH parameters (rectum V 30Gy , bowel cavity V 45Gy ) were estimated by scaling patient-specific averages of rectum V 30Gy -fx and bowel cavity V 45Gy -fx with the prescribed number of fractions. Alternatively, CTs were registered deformably to the full bladder planning CT using the hybrid deformable registration algorithm implemented in RayStation [21]. Based on these registrations, fraction dose distributions were warped and weighted accumulated to derive total delivered dose distributions.…”

Section: Oar Toxicitymentioning

confidence: 99%

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Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer

et al. 2016

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Background Image-guided adaptive proton therapy (IGAPT) can potentially be applied to take into account interfraction motion while limiting organ at risk (OAR) dose in cervical cancer radiation therapy (RT). In this study, the potential dosimetric advantages of IGAPT compared with photonbased image-guided adaptive RT (IGART) were investigated. Material and methods For 13 cervical cancer patients, full and empty bladder planning computed tomography (CT) images and weekly CTs were acquired. Based on both primary clinical target volumes (pCTVs) [i.e. gross tumor volume (GTV), cervix, corpus-uterus and upper part of the vagina] on planning CTs, the pretreatment observed full range primary internal target volume (pITV) was interpolated to derive pITV subranges. Given corresponding ITVs (i.e. pITVs including lymph nodes), patient-specific photon and proton plan libraries were generated. Using all weekly CTs, IGART and IGAPT treatments were simulated by selecting library plans and recalculating the dose. For each recalculated IGART and IGAPT fraction, CTV (i.e. pCTV including lymph nodes) coverage was assessed and differences in fractionated substitutes of dose-volume histogram (DVH) parameters (V 15Gy , V 30Gy , V 45Gy , D mean , D 2cc ) for bladder, bowel and rectum were tested for significance (Wilcoxon signed-rank test). Also, differences in toxicity-related DVH parameters (rectum V 30Gy , bowel V 45Gy ) were approximated based on accumulated dose distributions. Results In 92% (96%) of all recalculated IGAPT (IGART) fractions adequate CTV coverage (V 95% 498%) was obtained. All dose parameters for bladder, bowel and rectum, except the fractionated substitute for rectum V 45Gy , were improved using IGAPT. Also, IGAPT reduced the mean dose to bowel, bladder and rectum significantly (p50.01). In addition, an average decrease of rectum V 30Gy and bowel V 45Gy indicated reductions in toxicity probabilities when using IGAPT. Conclusion This study demonstrates the feasibility of IGAPT in cervical cancer using a plan-library based plan-of-the-day approach. Compared to photon-based IGART, IGAPT maintains target coverage while significant dose reductions for the bladder, bowel and rectum can be achieved.

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Section: Discussionmentioning

confidence: 99%

Section: Oar Toxicitymentioning

confidence: 99%

Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer

et al. 2016

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“…3DCRT, IMRT, and VMAT plans were then calculated in each of the manifested patient geometries observed during treatment. The CBCT images were deformably registered with the planning CT using the ANACONDA [18] algorithm available within the RayStation ® TPS. The deformations were then applied to the dose cube calculated on the CBCT to enable dose summation, thereby allowing us to calculate an estimate of the delivered accumulated dose.…”

Section: Dose Accumulationmentioning

confidence: 99%

Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers

et al. 2016

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This study demonstrates the superiority of IMRT/VMAT techniques over 3DCRT in terms of dose homogeneity, conformity and consistent dose delivery to the PTV throughout the course of treatment in patients with lateralised oropharyngeal cancers. Dosimetry and NTCP calculations show that these techniques are equivalent to 3DCRT with regard to the risk of acute mucositis when specific dose constraint objectives were used on the contralateral oral cavity OAR.

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“…Yeo et al6 demonstrated that the Optical Flow algorithm can perform accurate DIR in low contrast regions. Demons is a well‐known algorithm for intensity‐based DIR 12. Both the Optical Flow and Demons algorithms have been used in deformable registration for commercial software 6, 12.…”

Section: Introductionmentioning

confidence: 99%

“…Demons is a well‐known algorithm for intensity‐based DIR 12. Both the Optical Flow and Demons algorithms have been used in deformable registration for commercial software 6, 12. Regarding the mapping direction, when the forward mapping is estimated, every voxel of the source image is pushed forward to its estimated position in the target image.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of eight deformable image registration (DIR) methods for tomotherapy megavoltage computed tomography (MVCT) images

Nobnop

Neamin

Chitapanarux

et al. 2017

J of Medical Radiation Sci

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IntroductionThe application of deformable image registration (DIR) to megavoltage computed tomography (MVCT) images benefits adaptive radiotherapy. This study aims to quantify the accuracy of DIR for MVCT images when using different deformation methods assessed in a cubic phantom and nasopharyngeal carcinoma (NPC) patients.MethodsIn the control studies, the DIR accuracy in air‐tissue and tissue‐tissue interface areas was observed using twelve shapes of acrylic and tissue‐equivalent material inserted in the phantom. In the clinical studies, the 1st and 20th fraction MVCT images of seven NPC patients were used to evaluate application of DIR. The eight DIR methods used in the DIRART software varied in (i) transformation framework (asymmetric or symmetric), (ii) DIR registration algorithm (Demons or Optical Flow) and (iii) mapping direction (forward or backward). The accuracy of the methods was compared using an intensity‐based criterion (correlation coefficient, CC) and volume‐based criterion (Dice's similarity coefficient, DSC).ResultsThe asymmetric transformation with Optical Flow showed the best performance for air‐tissue interface areas, with a mean CC and DSC of 0.97 ± 0.03 and 0.79 ± 0.11 respectively. The symmetric transformation with Optical Flow showed good agreement for tissue‐tissue interface areas with a CC of (0.99 ± 0.01) and DSC of (0.89 ± 0.03). The sequences of target domains were significantly different in tissue‐tissue interface areas.ConclusionsThe deformation method and interface area affected the accuracy of DIR. The validation techniques showed satisfactory volume matching of greater than 0.7 with DSC analysis. The methods can yield acceptable results for clinical applications.

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The ANACONDA algorithm for deformable image registration in radiotherapy

Abstract: ANACONDA performs well in comparison with other algorithms. By including CT/CBCT data in the validation, the various aspects of the algorithm such as its ability to handle different modalities, large deformations, and air pockets are shown.

Cited by 224 publications

References 62 publications

Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer

Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer

Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers

Accuracy of eight deformable image registration (DIR) methods for tomotherapy megavoltage computed tomography (MVCT) images

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