The anabolic–androgenic steroid nandrolone induces alterations in the density of serotonergic 5ht1b and 5ht2 receptors in the male rat brain

Kindlundh, Anna M.S.; Lindblom, Jessica; Bergström, Lena; Nyberg, Fred

doi:10.1016/s0306-4522(03)00120-9

Cited by 58 publications

(50 citation statements)

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“…In AH, 5HT1A receptors are also reduced [142], while 5HT1B receptors are down-regulated in the medial globus pallidus and the CA1 region of hippocampus [94]. By contrast, AAS increase serotonin levels in cerebral cortex [99], and 5HT2 receptors in Acb [94]. In male volunteers receiving injections of methyltestosterone, levels of the serotonin metabolite 5-hydroxyindolacetic acid in cerebrospinal fluid increased, and this was correlated with activation symptoms: energy, sexual arousal, diminished sleep [42].…”

Section: Serotoninmentioning

confidence: 97%

“…Specifically, AAS treatment reduces serotonin in basal forebrain and dorsal striatum [102], including loss of fiber staining in brain regions controlling aggression and social behavior: Me, and the anterior (AH) and ventrolateral hypothalamus [68]. In AH, 5HT1A receptors are also reduced [142], while 5HT1B receptors are down-regulated in the medial globus pallidus and the CA1 region of hippocampus [94]. By contrast, AAS increase serotonin levels in cerebral cortex [99], and 5HT2 receptors in Acb [94].…”

Section: Serotoninmentioning

confidence: 99%

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Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

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Anabolic-androgenic steroids (AAS) are drugs of abuse. They are taken in large quantities by athletes and others to increase performance, with negative health consequences. As a result, in 1991 testosterone and related AAS were declared controlled substances. However, the relative abuse and dependence liability of AAS have not been fully characterized. In humans, it is difficult to separate the direct psychoactive effects of AAS from reinforcement due to their systemic anabolic effects. However, using conditioned place preference and self-administration, studies in animals have demonstrated that AAS are reinforcing in a context where athletic performance is irrelevant. Furthermore, AAS share brain sites of action and neurotransmitter systems in common with other drugs of abuse. In particular, recent evidence links AAS with opioids. In humans, AAS abuse is associated with prescription opioid use. In animals, AAS overdose produces symptoms resembling opioid overdose, and AAS modify the activity of the endogenous opioid system. KeywordsAnabolic agents; Testosterone; self-administration; hamsters; drug dependence • Breakfast of champions: Recent history and prevalence of AAS useAnabolic-androgenic steroids (AAS) are a hot topic. A search of the Google news archive in March 2007 reveals 47,500 news stories on "steroids" in 2006, a 400% increase since their debut in the archive in 2002. In 2006, "steroids" even surpassed trend-setters such as "Paris Hilton" (38,500 stories) or "spinach" (42,700 stories). Current media attention on AAS abuse has been driven by accusations of steroid use among professional athletes in baseball, track, and cycling. However, public recognition of AAS use in sports dates back nearly 20 years, when Ben Johnson tested positive for stanozolol at the Seoul Olympics in 1988 [77]. Eastern Block athletes had been using steroids since the 1950's, and the International Olympic Committee banned steroid use from Olympic competition in 1976. However, the ability to reliably detect androgen metabolites in urine samples was limited until the advent of gas chromatography-mass spectroscopy [89]. Johnson's drug test spurred the United States Congress to pass the Anabolic Steroid Control Act of 1991 which declared steroids as Address all reprint requests and correspondence to Ruth I. Wood, Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo St., BMT 401, Los Angeles, CA 90033. Telephone (323) 442-1980, Fax: (323) 442-3466, e-mail: riw@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain....

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Section: Serotoninmentioning

confidence: 97%

Section: Serotoninmentioning

confidence: 99%

Anabolic–androgenic steroid dependence? Insights from animals and humans

Wood

2008

Frontiers in Neuroendocrinology

136

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“…They may increase beta-endorphin levels in the ventral tegmental area and the thalamus, decrease levels of kappa receptors in the nucleus accumbens and increase: mu, delta and kappa receptor binding in the hypothalamus, striatum and midbrain periaqueductal gray [21,22]. AAS reduce the expression of serotonin receptors in the anterior hypothalamus (1A), globus pallidus (1B) or hippocampus [23,24]. They decrease serotonin concentration in basal forebrain and dorsal striatum [25], but increase in the cerebral cortex [26].…”

Section: Discussionmentioning

confidence: 99%

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

L¹

2013

J Steroids Horm Sci

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Objective: Androgenic-anabolic steroids (AAS) are commonly used by athletes and recreational athletes. In some cases they induce persistent anabolic steroid-induced hypogonadism (ASIH). Design:In an observational study we assessed the function of the pituitary-gonadal axis in a series of men with suspected ASIH. Methods:Clomiphene stimulation test (CST) was performed in 13 hypogonadal adult men with previous, prolonged exposure to AAS. We evaluated the response of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T) to 50 mg of clomiphene daily administered for a week.Results: Mean concentrations of hormones before and after clomiphene administration were respectively (mean ± SD): 3 ± 1.2 and 8.3 ± 2 mIU/ml for LH; 3 ± 1.1 and 10 ± 14.6 mIU/ml for FSH; and 2.3 ± 0.6 and 7.2 ± 1.7 ng/ml for T (p<0.001). Conclusions:Men with ASIH, after a long-time withdrawal of AAS, present an intact reaction of gonadotropins and testosterone to clomiphene stimulation.

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“…Camundongos tratados com a mesma droga cronicamente apresentaram diminuição na quantidade de RNAm do receptor dopaminérgico D1 nos núcleos caudado-putâmen e núcleo acumbens (Kindlundh et al, 2001;Kindlundh et al, 2003), receptor também implicado à modulação do comportamento agressivo (Volavka et al, 2004). Outros estudos tentam correlacionar as alterações comportamentais aos efeitos dos EAA nas neurotransmissões centrais serotoninérgicas, gabaérgicas, entre outras, em diversas áreas do cérebro (Thiblin et al, 1999;Hallberg et al, 2000;Yang, 2002 (Mazer et al, 1997;Lesch, 2001).…”

Section: -Esteróides Anabolizantes E Comportamentos Emocionaisunclassified

“…Estudos utilizando o decanoato de nandrolona sugerem uma participação dos EAA na modulação serotoninérgica, levando a uma diminuição na densidade de receptores 5HT 1B no hipocampo e aumento na densidade de receptores 5HT2 no núcleo acumbens (Kindlundh et al, 2001;Kindlundh et al, 2003), receptores estes já relacionados à modulação do comportamento agressivo Volavka et al, 2004).…”

Section: -Esteróides Anabolizantes E O Sistema Serotoninérgicounclassified

Efeitos da administração prolongada do esteróide anabolizante decanoato de nandrolona em comportamentos emocionais e na expressão de genes relacionados ao sistema serotoninérgico em diferentes áreas cerebrais de camundongos

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The anabolic–androgenic steroid nandrolone induces alterations in the density of serotonergic 5ht1b and 5ht2 receptors in the male rat brain

Cited by 58 publications

References 61 publications

Anabolic–androgenic steroid dependence? Insights from animals and humans

Anabolic–androgenic steroid dependence? Insights from animals and humans

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

Efeitos da administração prolongada do esteróide anabolizante decanoato de nandrolona em comportamentos emocionais e na expressão de genes relacionados ao sistema serotoninérgico em diferentes áreas cerebrais de camundongos

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