The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms

Paré, Denis; Headley, Drew B.

doi:10.1016/j.ynstr.2023.100529

Cited by 10 publications

(4 citation statements)

References 135 publications

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“…These interactions appear to depend on the generation of synchronous theta oscillations among these structures, which create recurring time windows that facilitate synaptic interactions and promote synaptic plasticity (Pape & Paré, 2010; Pelletier & Paré, 2004). This is thought to occur during both wakefulness and sleep (Paré, 2003; Paré & Headley, 2023).…”

Section: Summary and Functional Considerationsmentioning

confidence: 99%

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

McDonald

2024

J of Neuroscience Research

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The projections of the basal forebrain (BF) to the hippocampus and neocortex have been extensively studied and shown to be important for higher cognitive functions, including attention, learning, and memory. Much less is known about the BF projections to the basolateral nuclear complex of the amygdala (BNC), although the cholinergic innervation of this region by the BF is actually far more robust than that of cortical areas. This review will focus on light and electron microscopic tract‐tracing and immunohistochemical (IHC) studies, many of which were published in the last decade, that have analyzed the relationship of BF inputs and their receptors to specific neuronal subtypes in the BNC in order to better understand the anatomical substrates of BF‐BNC circuitry. The results indicate that BF inputs to the BNC mainly target the basolateral nucleus of the BNC (BL) and arise from cholinergic, GABAergic, and perhaps glutamatergic BF neurons. Cholinergic inputs mainly target dendrites and spines of pyramidal neurons (PNs) that express muscarinic receptors (MRs). MRs are also expressed by cholinergic axons, as well as cortical and thalamic axons that synapse with PN dendrites and spines. BF GABAergic axons to the BL also express MRs and mainly target BL interneurons that contain parvalbumin. It is suggested that BF‐BL circuitry could be very important for generating rhythmic oscillations known to be critical for emotional learning. BF cholinergic inputs to the BNC might also contribute to memory formation by activating M1 receptors located on PN dendritic shafts and spines that also express NMDA receptors.

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Section: Summary and Functional Considerationsmentioning

confidence: 99%

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

McDonald

2024

J of Neuroscience Research

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“…Secondly, the results of this study demonstrate the affordances of altruistic communication via television. Prior studies examining non-profit organization communications have examined communication through other platforms such as social media [18], billboard communication, and interpersonal communication [80,81]. However, different modes of communication work differently, such that the communication dynamics on a specific mode may not necessarily apply to other modes.…”

Section: Theoretical Implicationsmentioning

confidence: 99%

Determinants of Memory Encoding of Altruistic Messages: M-Delphi and F-DEMATEL Approach

Liao

2023

Applied Sciences

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One of the key challenges of non-profit organizations is the effective communication of values beneficial to society, such as altruism. Communication can be deemed effective if the message is memory encoded by the recipient. This paper applies social cognitive theory to analyze the determinants of the memory encoding of altruistic messages transmitted to audiences via television. The data were analyzed by the modified Delphi [M-Delphi) and Fuzzy Decision-Making Trial and Evaluation Laboratory [F-DEMATEL). The researchers initially proposed ten factors, and two factors were added after the first Delphi round. The analysis revealed three causal factors and four effect factors. The findings provide several contributions to communication literature. They also provide managerial implications for managers in non-profit organizations on the effective communication of altruism.

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“…The amygdala is necessary for the encoding emotional valence, emotional learning and regulation of the stress responses [24][25][26][27]. Substantial evidence has been provided that during emotional events one particular subregion of the structure -the basolateral complex of the amygdala (BLA) -incorporates the arousal signals originating from inside the brain (greater NA release from the LC) and from the peripheral hormone systems (heighten corticosterone level) to foster a positive modulatory effect on the processes required for the initial consolidation of memories [9,[28][29][30][31][32]. Therefore, the BLA could also influence the prioritization of information in the hippocampus [33].…”

Section: Introductionmentioning

confidence: 99%

Noradrenergic Transmission in the Basolateral Amygdala Mediates the Effects of Predatory Odor Exposure on Hippocampal Plasticity – a New Concept for Studying the Emotional Modulation of Memory Consolidation

Peshev,

Ivanova,

Krushovlieva

et al. 2024

Preprint

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The pivotal role of the basolateral amygdala (BLA) in the emotional modulation of hippocampal plasticity and memory consolidation is well established. Specifically, multiple studies have demonstrated that the activation of the noradrenergic (NA) system within BLA governs these modulatory effects. However, most of the current evidence has been obtained by direct infusion of synthetic NA or beta-adrenergic agonists. In the present study, we aimed to investigate the effect of endogenous NA release in the BLA, induced by a natural aversive stimulus (coyote urine), on memory consolidation for a neutral hippocampal-dependent task. We combined a weak version of the object location task (OLT) with mild predator odor exposure (POE) for our experiments. To investigate the role of the BLA in memory modulation, a subset of the animals (Wistar rats) were treated with the non-selective beta-blocker propranolol at the end of the behavioral procedures. Hippocampal tissue was collected either 90 minutes after drug infusion or 24 hours after the OLT test. The samples were used to determine the levels of phosphorylated CREB (pCREB) and activity-regulated cytoskeleton-associated protein (Arc) - two molecular markers of experience-dependent changes in neuronal activity. The result suggests that POE is a behavioral paradigm suitable for studying the interaction between BLA and the hippocampus in memory prioritization and selectivity.

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The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms

Cited by 10 publications

References 135 publications

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

Determinants of Memory Encoding of Altruistic Messages: M-Delphi and F-DEMATEL Approach

Noradrenergic Transmission in the Basolateral Amygdala Mediates the Effects of Predatory Odor Exposure on Hippocampal Plasticity – a New Concept for Studying the Emotional Modulation of Memory Consolidation

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