The Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma as a Biological Marker for Predicting Mortality in Community-Acquired Pneumonia: A Cohort Study

Tazón-Varela, Manuel Antonio; Muñoz-Cacho, Pedro; Valle, Héctor Alonso; Gallo-Terán, J.; Pérez-Mier, Luis Angel; Colomo-Mármol, Luis Fernando

doi:10.5152/eajem.2016.09068

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…A growing body of evidence says that infectious diseases cause cardiovascular complications in the short and medium term. There is increasing evidence of the relationship between bacterial pneumonia or COVID-19 infection and important cardiovascular complications with increased biomarkers [6][7][8]. IVI is not an exception, increasing deaths from cardiovascular problems during influenza epidemics and triggering or aggravating episodes of arrhythmias, acute coronary syndrome, acute myocarditis, or acute heart failure [9].…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza

Tazón-Varela

Salido-Menchaca²,

Muñoz-Cacho

et al. 2022

JPM

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The purpose of the study was to analyze the relationship between the high-sensitivity troponin T levels in patients with confirmed influenza virus infection and its severity determined by mortality during the care process. In addition, a high-sensitivity troponin T cut-off value was sought to allow us to a safe discharge from the emergency department. An analytical retrospective observational study was designed in which high-sensitivity troponin T is determined as an exposure factor, patients are followed until the resolution of the clinical picture, and the frequency of mortality is analyzed. We included patients ≥ 16 years old with confirmed influenza virus infection and determination of high-sensitivity troponin T. One hundred twenty-eight patients were included (96.9% survivors, 3.1% deceased). Mean and median blood levels of high-sensitivity troponin T of survivors were 26.2 ± 58.3 ng/L and 14.5 ng/L (IQR 16 ng/L), respectively, and were statistically different when compared with those of the deceased patients, 120.5 ± 170.1 ng/L and 40.5 ng/L (IQR 266.5 ng/L), respectively, p = 0.012. The Youden index using mortality as the reference method was 0.76, and the cut-off value associated with this index was 24 ng/L (sensitivity 100%, specificity 76%, NPV 100%, PPV 4%) with AUC of 88,8% (95% CI: 79.8–92.2%), p < 0.001. We conclude that high-sensitivity troponin T levels in confirmed virus influenza infection are a good predictor of mortality in our population, and this predictor is useful for safely discharging patients from the emergency department.

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