The Amino Acid Pool in Oncology: Plastic Substrates, Specific Regulators of Metabolism and Markers

Abstract

On the basis of experimental data we suggest that discovered differences in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostic of primary cancerous growth as well as, in estimation of the effectiveness of specific cancer treatment. In clinical studies (1,495 patients with cancer of mammary gland, lungs, prostate, ovaries, bladder or digestive tract) biological fluids and tumors of cancer patients significant changes of physiological concentrations of amino acids real or indirectly regulate processes of the antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a directional effect on the functional and metabolic relationships which change in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application in oncology of their regulatory effects was discussed.that practically ignored their regulatory effects on metabolic processes and key metabolic reactions.To understand the metabolic processes and vital functions of the regulatory effect of amino acids, this manifests itself under natural or near concentrations of these compounds in body fluids and tissues. It is obvious that the effective use of L-amino acids or their derivatives for metabolic correction and directional changes in metabolism in pathological or extreme conditions limited accumulation of information about theme mechanisms of regulatory effects of the compounds tested at concentrations comparable to their physiological (endogenous) level [1][2][3][4][5][6][7][8][9][10]. Materials and Methods Our development methodology is based on• The study of physiological concentrations of free amino acids, their derivatives, precursors and metabolites, as well as, biochemical marker parameters in healthy donors and patients with various pathologies.• Creating a unified database for the studied parameters, construction of empirical mathematical model consisting of pathogenic markers specific pathology and amino acid profiles.• Specialized development of new formulations of the compositions of infusion solutions of amino acids and their Journal of Patient CareJo u r n al of Pati en t C a re