The American College of Rheumatology 1990 criteria for the classification of wegener's granulomatosis

Leavitt, Randi Y.; Fauci, Anthony S.; Blöch, D.; Michel, Beat A.; Hunder, Gene G.; Arend, William P.; Calabrese, Leonard H.; Fries, James F.; Lie, J.T.; Lightfoot, Robert W.; Masi, Alfonse T.; McShane, Dennis J.; Mills, John A.; Stevens, Mary Betty; Wallace, Stanley L.; Zvaifler, Nathan J.

doi:10.1002/art.1780330807

Cited by 1,719 publications

(751 citation statements)

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“…Forty-two patients with GPA (42 serum samples from 22 men and 20 women, mean Ϯ SD age 44.7 Ϯ 17.4 years, range 16-73 years) were included in the study. All patients were positive for anti-PR3 antibodies and met the Chapel Hill Consensus Conference Nomenclature/Criteria for Vasculitis (13) and/or the American College of Rheumatology criteria for GPA (14).…”

Section: Methodsmentioning

confidence: 99%

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Espy

Morelle²,

Kavian

et al. 2011

Arthritis & Rheumatism

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Objective. To investigate whether the glycosylation and sialylation levels of anti-proteinase 3 (anti-PR3) antibodies could affect their pathogenicity, and whether these levels could be correlated with the activity of granulomatosis with polyangiitis (Wegener's) (GPA).Methods. Forty-two serum samples positive for anti-PR3 antibodies from 42 patients with active or weakly active/inactive GPA were included. Anti-PR3 antibodies were assayed by enzyme-linked immunosorbent assay, and their levels of glycosylation and sialylation were assessed by enzyme-linked lectin assay. The glycosylation and sialylation levels of IgG purified from the serum of healthy donors and patients with active, remitted, or weakly active disease were assessed by permethylation and mass spectrometry analysis of glycans, following neuraminidase digestion. The neutrophil oxidative burst induced by purified IgG was assayed by spectrofluorimetry.Results. The mean sialylation ratio of anti-PR3 antibodies was significantly lower in patients with active disease than in patients with weakly active or inactive disease, and this was inversely correlated with the Birmingham Vasculitis Activity Score (BVAS) (P < 0.0001). Similar results were obtained using the BVAS/ GPA. The area under the receiver operating characteristic curve for the sialylation ratio of anti-PR3 antibodies, as a test to determine the activity of GPA, was 0.82 (P ‫؍‬ 0.0006). The characterization of N-glycans showed a decrease in 2,6-linked sialylated N-glycans and an increase in dHex 1 Hex 3 HexNAc 4 (mass/charge 1,836) agalactosylated structures in purified IgG from patients with active disease compared with controls. The anti-PR3 antibody-induced oxidative burst of neutrophils was inversely correlated with the sialylation levels of anti-PR3 IgG.

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Section: Methodsmentioning

confidence: 99%

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Espy

Morelle²,

Kavian

et al. 2011

Arthritis & Rheumatism

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“…Generalized WG was diagnosed on the basis of the abnormal urinary sediment and renal involvement with rapidly progressive glomerulonephritis, elevation of the ESR and cANCA and CRP levels, polyarthritis, and anemia (5). When the diagnosis was confirmed, oral cyclophosphamide (100 mg/day) was added to the treatment regimen.…”

Section: Case Reportmentioning

confidence: 99%

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Varani¹,

Mastroianni²,

Frascaroli³

et al. 2009

Arthritis & Rheumatism

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Human cytomegalovirus (HCMV) is frequently detected in autoimmune diseases, but its role in such disorders is poorly understood. Herein we describe the case of a young woman who developed generalized Wegener's granulomatosis (WG) after HCMV mononucleosis and urinary tract infection. During mononucleosis, the patient had extraordinarily high plasma levels of proinflammatory cytokines such as interleukin-5 and lymphotoxin ␣, autoantibodies, and a higher blood level of viral DNA than were found in other immunocompetent patients infected with HCMV or healthy controls. Active HCMV replication was detected after the onset of vasculitis, and HCMV genomes or antigens were found in blood, urine, and inflammatory lesions on the kidney. Thus, HCMV may have triggered or exacerbated inflammation and autoimmunity in this case of WG.

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“…The differences between the ACR criteria [32,[36][37][38] and the Ankara 2008 criteria [10] are summarized in Table 2.…”

Section: Ankara 2008 Criteriamentioning

confidence: 99%

“…The ACR classification criteria were developed prior to ANCA being defined [37]. It is now known that approximately 90 % of GPA (WG) patients are ANCA-positive (mostly PR3-ANCA) [42].…”

Section: Granulomatous Polyangiitis (Wg)mentioning

confidence: 99%

Vasculitis: do we know more to classify better?

Batu

Özen

2014

Pediatr Nephrol

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The systemic vasculitides are a heterogeneous group of disorders characterized by the inflammation of blood vessels. The development and implementation of advanced diagnostic tests and genetic studies have resulted in substantial improvement in our understanding of vasculitis pathogenesis, resulting in the revision of the nomenclature and classification for vasculitis. Multicenter, collaborative studies are currently underway to develop improved diagnostic criteria. In this review, the major nomenclature and classification systems for vasculitides are summarized, with special emphasis on those emerging from the recent 2012 Chapel Hill Consensus Conference (CHCC).

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The American College of Rheumatology 1990 criteria for the classification of wegener's granulomatosis

Cited by 1,719 publications

References 11 publications

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Vasculitis: do we know more to classify better?

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