The ameliorative role of methionine in hepatic steatosis and stress response in juvenile black seabream (Acanthopagrus schlegelii) fed with a high-fat diet

Yang, Bingqian; Shen, Yuedong; Monroig, Óscar; Zhao, Wenli; Bao, Yangguang; Tao, Shunshun; Jiao, Lefei; Zhou, Qicun; Jin, Min

doi:10.1016/j.aquaculture.2023.740306

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…Although broad bean is rich in a wide range of nutrients, the amino acid composition of broad bean is unbalanced, especially lacking in methionine (Meng et al, 2021). Methionine is one of the essential amino acids for aquatic animals, and its deficiency caused intestinal flora disorders and liver fat accumulation (Hu et al, 2022;Yang et al, 2024). We also observed this phenomenon in the livers of grass carp fed a single broad bean diet, suggesting that methionine deficiency in broad bean may be one of the key factors causing liver steatosis in grass carp.…”

Section: Analysis and Treatment Of Potential Factors Inducing Hepatic...mentioning

confidence: 99%

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Fu,

Ma,

Yang

et al. 2024

Food Frontiers

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Broad bean (Vicia faba L.) has received attention from the food and animal feed industries as a sustainable, inexpensive, and versatile plant‐based protein source. However, long‐term consumption of broad bean, especially unprocessed ones, can lead to hepatic lipid accumulation. To investigate how broad bean affected hepatic lipid metabolism and its underlying mechanisms, we conducted a multi‐omics analysis of crisp grass carp (Ctenopharyngodon idellus C. et V) model with hepatic steatosis after feeding with single broad bean for 120 days. The glycolysis inhibition, increased de novo lipogenesis, abnormalities in lipid metabolism, and activation of oxidative stress were the key processes involved in broad bean‐induced hepatic lipid accumulation. Disturbances in intestinal flora caused by damage to the intestinal barrier and increased lipopolysaccharide caused by broad bean promoted hepatic lipid accumulation. Reduction of antinutritional factors and balanced diet offer potential strategies to mitigate the liver damage caused by broad bean consumption. Overall, our findings provided a theoretical basis for the wide application of broad bean as animal feeds.

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Section: Analysis and Treatment Of Potential Factors Inducing Hepatic...mentioning

confidence: 99%

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Fu,

Ma,

Yang

et al. 2024

Food Frontiers

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show abstract

“…The elevations in plasma TC, TG, LDL-c, and HDL-c following an HFD indicate a significant disruption in lipid metabolism [40]. Specifically, the increase in LDL-c and TC are concerning, pointing to an elevated risk of fatty liver disease development, which can further compromise fish health through the enhancement of oxidative stress and inflammatory responses [41]. Although the increase in HDL-c is often deemed positive in health due to its role in facilitating the reverse transport of cholesterol, its simultaneous elevation with LDL-c and TG after an HFD feeding may suggest an incapacity in the lipid regulatory system in fish [42].…”

Section: Effects Of Berberine On the Metabolism Functionmentioning

confidence: 99%

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Jia,

Hou,

Zhang

et al. 2024

Antioxidants

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Berberine, a natural alkaloid found abundantly in various medicinal plants, exhibits antioxidative, anti-inflammatory, and lipid metabolism-regulatory properties. Nonetheless, its protective effects and the molecular mechanisms underlying liver injury in fish have not been fully elucidated. The aims of this study were to investigate the antioxidative, anti-inflammatory, and lipid metabolism-regulating effects of berberine against high-fat diet (HFD)-induced liver damage and to clarify the underlying molecular mechanisms. Tilapia were fed diets containing two doses of berberine (50 and 100 mg/kg diet) alongside high fat for 60 days. The results showed that berberine treatments (50 and/or 100 mg/kg) significantly reduced elevated aminotransferases, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) in the plasma. In the liver, berberine treatments significantly increased the expression of peroxisome proliferator-activated receptor α (pparα) and carnitine palmitoyltransferase 1 (cpt-1) genes, leading to a reduction in lipid accumulation. Meanwhile, berberine treatment suppressed lipid peroxidation formation and enhanced antioxidant capacity. Berberine upregulated the mRNA levels of erythroid 2-related factor 2 (nrf2) and its downstream genes including heme oxygenase 1 (ho-1) and glutathione-S-transferase (gstα). Additionally, berberine attenuated the inflammation by inhibiting the expression of toll-like receptor 2 (tlr2), myeloid differential protein-88 (myd88), relb, and inflammatory cytokines such as interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and il-8. In summary, this study suggested that berberine offers protection against HFD-induced liver damage in tilapia via regulating lipid metabolism, antioxidant status, and immune response. This protective effect may be attributed to the modulation of the Nrf2, TLR2/MyD88/NF-κB, and PPARα signaling pathways.

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Metabolomics provides insights into the alleviating effect of dietary Caulerpa lentillifera on diquat-induced oxidative damage in zebrafish (Danio rerio) liver

Lin,

Liu,

Xiao

et al. 2024

Aquaculture

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The ameliorative role of methionine in hepatic steatosis and stress response in juvenile black seabream (Acanthopagrus schlegelii) fed with a high-fat diet

Cited by 4 publications

References 60 publications

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Metabolomics provides insights into the alleviating effect of dietary Caulerpa lentillifera on diquat-induced oxidative damage in zebrafish (Danio rerio) liver

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