The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats

Rababa’h, Abeer; Matani, Bayan R.; Ababneh, Mera A.

doi:10.1016/j.lfs.2020.118353

Cited by 21 publications

(25 citation statements)

References 44 publications

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“…Although an impaired glucose regulation was observed in the DHEA group, the body weight was also decreased unexpectedly in our study. According to existing research, some studies indicated that DHEA can increase the body weight, while other studies showed that the DHEA group could have a tendency to lose weight as well ( 33 , 34 ). We speculated that it may be related to the following aspects: 1) a low dose of DHEA could prevent the development of obesity ( 35 – 37 ); 2) DHEA can reduce the food intake of rodents ( 38 ); 3) experimental procedures such as injection therapy or vaginal smears invisibly increase the amount of exercise.…”

Section: Discussionmentioning

confidence: 99%

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

et al. 2021

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Polycystic ovary syndrome (PCOS) is a complex reproductive, endocrine, and metabolic disorder in reproductive-age women. In order to explore the active metabolites of brown adipose tissue (BAT) transplantation in improving the reproductive and metabolic phenotypes in a PCOS rat model, the metabolites in the recipient’s BAT were explored using the liquid chromatography–mass spectrometry technique. In total, 9 upregulated and 13 downregulated metabolites were identified. They were roughly categorized into 12 distinct classes, mainly including glycerophosphoinositols, glycerophosphocholines, and sphingolipids. Ingenuity pathway analysis predicted that these differentially metabolites mainly target the PI3K/AKT, MAPK, and Wnt signaling pathways, which are closely associated with PCOS. Furthermore, one of these differential metabolites, sphingosine belonging to sphingolipids, was randomly selected for further experiments on a human granulosa-like tumor cell line (KGN). It significantly accelerated the apoptosis of KGN cells induced by dihydrotestosterone. Based on these findings, we speculated that metabolome changes are an important process for BAT transplantation in improving PCOS. It might be a novel therapeutic target for PCOS treatment.

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Section: Discussionmentioning

confidence: 99%

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

et al. 2021

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“…It was found that marjoram administration on DHEA-induced PCOS was most beneficial. There was an improvement in hormonal levels, there was a reduction in ovarian weight, increased insulin sensitivity, increased antioxidants, and increased antiinflammatory parameters [30].…”

Section: Treatmentsmentioning

confidence: 96%

“…Shifting the focus towards a potential herbal treatment method, in a randomized control study by Rababa'h et al, the effects of the marjoram plant on the hormonal effects of PCOS was studied [30]. There were five randomly assigned groups, which included a control group, a dehydroepiandrosterone induced-PCOS model group, a marjoram-treated PCOS group, a metformin-treated PCOS group and a PCOS group treated with a combination of marjoram and metformin [30]. It was found that marjoram administration on DHEA-induced PCOS was most beneficial.…”

Section: Treatmentsmentioning

confidence: 99%

A Literature Review of the Effects of PCOS on Cardiovascular Health

Mundle

Raza

2021

URNCST Journal

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Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder found in individuals with female reproductive organs. It is known to cause excess production of androgens, which leads to a wide variety of issues, ranging from complications with bodily function and changes in physical appearance. This review will specifically focus on the relationship between PCOS and its effects on cardiovascular health to understand the long-term implications of the disorder. The variety of treatments used for PCOS and how they affect cardiovascular health will also be explored. Methods: Research over a span of 30 years was compiled to examine the effects of PCOS on women's cardiovascular health outcomes. Results: The findings support that there is indeed an adverse relationship between PCOS and cardiovascular health; however, treatments are available to combat these effects. PCOS has a negative influence on the health of the cardiovascular system; it increases the risk of hypertension and blood vessel/artery damage, metabolic disturbances such as diabetes, dyslipidemia, and insulin resistance, and has negative implications (undesirable effects) on hormones, such as insulin and androgen levels. There are multiple interventions ranging from oral contraception (OCP), lifestyle changes, and herbal medications that can reverse the effects of PCOS on the cardiovascular system. Due to the nature of PCOS, however, the results of the studies examined in this review are not an exact prospect for every affected individual and will require extensive research. Furthermore, more research is required to continue to understand other biological factors in this relationship, as well as looking into social determinants that may enhance or alter these results. Conclusion:Ultimately, this review intends to promote further studies of the long-term effects of this hormonal disorder. Further research will not only improve the current treatment processes but may also benefit the conversation around this topic so that those who do struggle with PCOS can be more cognizant of its potential health outcomes.

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“…Because these herbs have properties of regulating lipid and carbohydrate metabolism they can be used by all phenotypes of PCOS women. Several of the herbs also have endocrine properties, these were the ones mentioned earlier: green tea [ 116 ] and marjoram ( Maiorana hortensis ) are some of the herbs whose effects include improvements in hormonal levels, ovaries weight, insulin sensitivity, antioxidants, and anti-inflammatory parameters [ 117 , 118 ].…”

Section: Lifestyle Changesmentioning

confidence: 99%

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

et al. 2021

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Here we present an extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was analyzed, combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs. The metabolic pathways leading to disturbances in lipid, carbohydrate, and hormonal metabolism in targeted patients are described. The article refers to sleep disorders, changes in mental health parameters, and causes of oxidative stress and inflammation. These conditions consistently lead to the occurrence of severe diseases in patients suffering from diabetes, the fatty degeneration of internal organs, infertility, atherosclerosis, cardiovascular diseases, dysbiosis, and cancer. The modification of lifestyles, diet patterns and proper selection of nutrients, pharmacological and natural supplementation in the form of herbs, and physical activity have been proposed. The progress and consequences of PCOS are largely modifiable and depend on the patient’s approach, although we have to take into account also the genetic determinants.

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The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats

Cited by 21 publications

References 44 publications

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

A Literature Review of the Effects of PCOS on Cardiovascular Health

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

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