The Ameliorative Effects of Caffeic Acid Phenethyl Ester in Cisplatin-Induced Nephrotoxicity: Assessment of the Oxidative Stress an Inflammation

Caffeic acid mitigates aflatoxinB1‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and the redox‐regulatory systems

“…CA is found mostly as ester conjugates including chlorogenic acids (esters of CA and quinic acid) and other related compounds (Espíndola et al, 2019). The reported pharmacological activities of CA include immunomodulatory activity (Kilani‐Jaziri et al, 2017), antiviral—including the human immunodeficiency virus—and immunostimulatory activity (Kilani‐Jaziri et al, 2017), cardioprotective activity (Agunloye et al, 2019), antidiabetic activity, antiatherosclerotic activity, antiproliferative activity (Xie et al, 2017), hepatoprotective activity (Akçam et al, 2013; Bispo et al, 2017), anticancer activity (Gu et al, 2016; McGlynn et al, 2015), and antioxidant properties (Agunloye et al, 2019; Ceylan et al, 2021; Stahli et al, 2019). The antioxidant activity of CA is due to the possession of delocalized aromatic rings and free electrons or hydrogen atoms that are easily donated to reactive oxygen species to stabilize them (Espíndola et al, 2019).…”