The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats

Acaröz, Ulaş; İnce, Sinan; Arslan‐Acaröz, Damla; Gürler, Zeki; Küçükkurt, İ̇smail; Demirel, Hasan Hüseyin; Arslan, Halil Ozancan; Varol, Nuray; Zhu, Kui

doi:10.1016/j.fct.2018.06.029

Cited by 96 publications

(64 citation statements)

References 47 publications

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“…In the present study, we demonstrated the anti-apoptotic, antioxidant and anti-in ammatory effects of curcumin on ACR-induced neurotoxicity in rats, suggesting the use of curcumin to prevent or delay neurological damages induced by ACR exposure. In line with the evidences from humans and animals [4,5,8,[11][12][13][14], our study showed that the 4-week exposure of rats to ACR at the dose of 40 mg/kg caused a signi cant body weight loss, progressive de cits in motor function and adverse pathological outcome in the cortex and hippocampus of rats. Importantly, the present data revealed that curcumin administration could e ciently rescue ACRinduced weight loss and neurobehavioral de cits, relieve the neuropathological damages in brain.…”

Section: Discussionsupporting

confidence: 87%

“…Moreover, ACR may have deleterious effects on antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) thus decrease the antioxidant defence in the brains [11,12]. Furthermore, many evidences [12,13] have shown the production of in ammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) was enhanced after ACR intoxication.…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, in recent years, some agents with anti-apoptosis, antioxidant and anti-in ammatory properties have been expected to attenuate ACR-induced neurotoxicity [3,8,[11][12][13][14]. As the most active constituent in turmeric, a common spice, with a strong safety record, curcumin has been considered to be a potential natural neuroprotective agent under limelight [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Guo

Cao

et al. 2020

Preprint

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Background: Acrylamide (ACR) formed during heating of tobacco and carbohydrate-rich food as well as widely applied in industries has been known as a well-established neurotoxic pollutant. Although the precise mechanism is unclear, enhanced apoptosis, oxidative stress and inflammation have been demonstrated to contribute to the ACR-induced neurotoxicity. In this study, we assessed the possible anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin, the most active component in a popular spice known as turmeric, on the neurotoxicity caused by ACR in rats.Methods: Curcumin at the dose of 50 and 100 mg/kg was orally given to ACR- intoxicated Sprague-Dawley rats exposed by ACR at 40mg/kg for 4 weeks. All rats were subjected to behavioral analysis. The HE staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) staining were used to detect histopathological changes and apoptotic cells, respectively. The mRNA and protein expressions of apoptosis-related molecule telomerase reverse transcriptase (TERT) were detected using real-time PCR and immunohistochemistry, respectively. The contents of malondialdehyde (MDA) and glutathione (GSH) as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured as the indicators for evaluating the level of oxidative stress in brain. The levels of pro-inflammatory cytokinestumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the cerebral homogenates were detected using ELISA assay.Results: ACR-induced weigh loss, deficits in motor function as well as pathological alterations in brains were significantly improved in rats administrated with 50 and 100 mg/kg curcumin. TUNEL-positive apoptotic cells in curcumin-treated ACR intoxicated brains were less than those in the ACR model group. Curcumin administration especially at the dose of 100 mg/kg upregulated the TERT mRNA expression and enhanced the number of TERT-positive cells in ACR-intoxicated cortex tissues. Moreover, curcumin treatment reduced the concentrations of TNF-α, IL-1β and MDA, while increased the GSH contents as well as the SOD and GSH-Px activities in the cerebral homogenates, in comparison to ACR control group.Conclusions: These data suggested the anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on ACR-induced neurotoxicity in rats. Maintaining TERT-related anti-apoptotic function might be one mechanism underlying the protective effect of curcumin on ACR-intoxicated brains.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Guo

Cao

et al. 2020

Preprint

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“…Oxidative stress deterioration is considered a major contributor in triggering and progressing AA-induced myocardial dysfunction [42]. AA exposure accelerates the level of ROS by disturbing oxidant-antioxidant balance and suppressing the antioxidant defense system [43]. It was previously known that compared to other tissues, the heart is selectively sensitive to ROS-induced damage because of its highly oxidative metabolism and lower abundance of antioxidant defenses [44].…”

Section: Discussionmentioning

confidence: 99%

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim

Alzahrani

Ali

et al. 2019

BioMed Research International

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Acrylamide (AA) is a well-known potent carcinogen and neurotoxin that has been recently linked to atherosclerotic pathogenesis. The present study is aimed at investigating the protective effect of silymarin (SIL) as an antioxidant against AA-induced hyperlipidemic cardiomyopathy in male rats. The obtained results showed that animals exposed to AA exhibited a significant increase in the levels of cardiac serum markers, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol with a significant decrease in high-density lipoprotein cholesterol. Furthermore, AA intoxication significantly increased the malondialdehyde level (a hallmark of lipid peroxidation) and reduced antioxidant enzyme activities (i.e., superoxide dismutase, catalase, and glutathione peroxidase). SIL administration significantly attenuated all these biochemical perturbations in AA-treated rats, except for the decreased high-density lipoprotein cholesterol. Our results were confirmed by histopathological assessment of the myocardium. In conclusion, this study demonstrated a beneficial effect of SIL therapy in the prevention of AA-induced cardiotoxicity by reversing the redox stress and dyslipidemia in experimental animals.

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“…In the current study, boron (particularly at doses of 10 and 20 mg/kg) suppressed the expression of proinflammatory cytokine genes (IFN‐γ, IL‐1β, TNF‐α, and NFκB). This may be explained by the antioxidant effects of boron, which inhibit the generation of ROS.…”

Section: Discussionmentioning

confidence: 99%

Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats

İnce

Küçükkurt

Acaröz

et al. 2018

J Biochem & Molecular Tox

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Arsenic, an element found in nature, causes hazardous effects on living organisms. Meanwhile, natural compounds exhibit protective effects against hazardous substances. This study evaluated the effects of boron against arsenic-induced genotoxicity and altered biochemical parameters in rats. Thirty-five male Wistar albino rats were equally divided into five groups, and the experimental period lasted 30 days. One group was used as the control, and another group was treated with 100 mg/L arsenic in drinking water. The other groups were orally treated with 5, 10, and 20 mg/kg boron plus arsenic (100 mg/L via drinking water). Arsenic caused changes in biochemical parameters, total oxidant/antioxidant status, and DNA damage in mononuclear leukocytes. Moreover, it increased IFN-γ, IL-1β, TNF-α, and NFκB mRNA expression levels in rat tissue. However, boron treatment improved arsenic-induced alterations in biochemical parameters and increases in DNA damage and proinflammatory cytokine gene expressions.

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The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats

Cited by 96 publications

References 47 publications

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats

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