The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB

Alshehri, Ali; El‐kott, Attalla F.; El-Kenawy, Ayman El-Meghawry; Zaki, M. J.; Morsy, Kareem; Ghanem, Reham A.; Salem, Eman T.; Ebealy, Eman R; Khalifa, Heba S; Altyar, Ahmed E.; AlGwaiz, Hussah I.M.; Ibrahim, Essam H.; Mahmoud, Mohammed S.; Dallak, Mohammad; Abd-Ella, Eman M

doi:10.1007/s11356-022-19876-7

Cited by 18 publications

(3 citation statements)

References 55 publications

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“…BUN and SCr are important indicators for judging the severity of the renal injury and are commonly used to evaluate renal function. Alshehri et al found that kaempferol decreased concentrations of BUN and SCr in a rat model of CdCl 2-induced kidney injury [22]. In this study, we found that kaempferol signifcantly improved the degree of kidney injury and decreased levels of injury parameters such as BUN and SCr in a mouse model of septic kidney injury.…”

Section: Discussionsupporting

confidence: 62%

Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway

Chen

Ye³

et al. 2023

Journal of Food Biochemistry

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Sepsis is the main cause of acute kidney injury (AKI), mainly due to systemic immune dysregulation. Kaempferol (KAE) is a natural flavonoid compound with multiple biological activities including anti-inflammatory, antioxidant, and antiapoptotic properties. In this study, we constructed a sepsis-induced AKI mouse model and an LPS-induced glomerular mesangial cell (HK-2) in vitro sepsis AKI model. We found that KAE ameliorated sepsis-induced renal pathological damage, reversed renal function damage, and inhibited p-p65 and p-AKT protein expression. In addition, KAE reversed LPS-induced proliferation and inhibited apoptosis in HK-2 cells. These studies suggest that KAE reverses sepsis by inhibiting activation of the NF-κB/AKT pathway to reverse acute kidney injury.

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Section: Discussionsupporting

confidence: 62%

Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway

Chen

Ye³

et al. 2023

Journal of Food Biochemistry

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“…Interestingly, kaempferol reduced the production of pro-inflammatory cytokines and subsequently inhibited monocyte adhesion and migration. Kaempferol inhibited NF-κB /Nrf2 activation, which contributed to alleviate renal injury in mouse model [ 49 ]. Also, Nrf2 decreased the expression of MCP-1 and VCAM-1 and consequently reduced monocyte adhesion and transmigration to endothelial cells, which reduced MAPK and p38 expression and alleviated the formation of atherosclerotic lesions in mice and rabbits [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Kaempferol improves acute kidney injury via inhibition of macrophage infiltration in septic mice

Wang

Kuang

et al. 2023

Bioscience Reports

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Sepsis contributes to life-threatening circulatory and organ dysfunction by dysregulating the host response to infection in critically ill patients. Treatment in an Intensive Care Unit (ICU) can improve the survival of patients who suffer from severe sepsis, but sepsis associated acute kidney injury(SAKI) is still one of the main causes of death. The existing treatment is mainly focused on controlling microorganism induced infections by using drugs, such as Ulinastatin and Glucocorticoid. Also, it is well documented that kaempferol, a flavonoid derived from plant sources, improves septic mouse survival via anti-inflammatory response. However, the mechanism of anti-inflammatory response mediated by this flavonoid compound was little known. This study aims to demonstrate the mechanisms of inflammatory response regulated by kaempferol treatment during sepsis. We perform cecal ligation and puncture (CLP) injury as a sepsis mouse model and evaluate organ injury in sepsis. The molecular (qRT-PCR and Western Blot) and cellular profiling (IHC staining and Flow Cytometry) of the immune responses illustrates that kaempferol decreases the expression of adhesion molecular genes (ICAM-1 and VCAM-1) and monocyte chemoattractant protein-1 (MCP-1), thereby inhibiting F4/80+ macrophages infiltration in CLP-induced acute kidney injury. Our data suggested that kaempferol alleviates acute kidney injury via regulating F4/80+ macrophages infiltration in CLP-induced acute kidney injury.

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“…It reduced oxidative stress, inflammation, and apoptotic markers while promoting antioxidant enzyme levels. Kaempferol's effects were associated with modulation of NF-kB p65 and Nrf2 pathways (Alshehri et al, 2022). Kaempferol attenuated D-ribose-induced changes in mesangial cells, possibly by repairing autophagy and reducing AGE accumulation and ROS production .…”

Section: Kaempferolmentioning

confidence: 90%

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

Hashim,

Badruddeen,

Akhtar

et al. 2023

J. Phytonanotech. Pharmaceut. Sci.

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Diabetic nephropathy is a debilitating complication of diabetes mellitus characterized by progressive kidney damage. This review provides a comprehensive overview of the molecular pathways underlying its pathogenesis and explores the protective mechanisms offered by various phytobioactives. The pathogenetic mechanisms of diabetic nephropathy are multifaceted, encompassing the activation of key pathways such as the rennin angiotensin-aldosterone system (RAAS), the polyol pathway, protein kinase C (PKC) pathway, hexosamine pathway, and the formation of advanced glycation end products (AGEs). Understanding these pathways is crucial for developing effective therapeutic strategies to combat diabetic nephropathy. In parallel, this review sheds light on the role of phytobioactives, including alkaloids, flavonoids, tannins, and stilbenes, in mitigating the progression of diabetic nephropathy. These natural compounds exhibit a spectrum of protective properties, including antioxidative and anti-inflammatory effects. Their ability to modulate the molecular pathways implicated in diabetic nephropathy offers promising avenues for novel therapeutic interventions. This review of the pathogenetic mechanisms and the protective potential of phytobioactives underscore the importance of considering natural compounds as adjunctive therapies in managing diabetic nephropathy, potentially improving patient outcomes and quality of life.

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The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB

Cited by 18 publications

References 55 publications

Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway

Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway

Kaempferol improves acute kidney injury via inhibition of macrophage infiltration in septic mice

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

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