The Ameliorative Effect of Fimasartan against Methotrexate-Induced Nephrotoxicity in Rats

Rasheed, Maryam; Hassan, Ali F.

doi:10.31351/vol31iss1pp87-94

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…On the eighth day, blood samples were collected from the external jugular vein, placed in a clot-activator gel tube, allowed to settle for about 15 minutes, and centrifuged at 3,000 rpm for 20 minutes [ 16 ]. The resulting supernatant (serum) was withdrawn by micropipette and transferred into Eppendorf tubes for the quantitative analysis of inflammatory markers (TNF-α, IL-6, iNOS) and the anti-inflammatory marker (IL-10) levels.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers

Hammoodi,

Al-Shawi

2023

JMedLife

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Ifosfamide (IFO), an alkylating chemotherapy agent, is known for its association with neurotoxicity and encephalopathy. This trial was designed to evaluate the protective action of daidzein (DZN) against IFO-induced neurotoxicity in male rats by determining the difference in certain inflammatory and apoptotic markers in the brain tissue of rats. Twenty-eight Wistar rats, weighing 120-150 g, were divided into four groups of seven rats: Group 1 (Control) received no treatment; Group 2 was orally administered DZN (100 mg/kg/day) for seven days; Group 3 received a single intraperitoneal (IP) dose of IFO (500 mg/kg); Group 4 received oral DZN (100 mg/kg/day) for one week prior to a single IP dose of IFO on the seventh day. Twenty-four hours post-treatment, serum and brain tissue samples were collected for analysis. The results indicated a significant increase in serum inflammatory markers (TNF-alpha, IL-6, and iNOS) and the anti-inflammatory marker (IL-10), along with elevated caspase-3 enzyme activity in the brain tissue of the IFO-treated group compared to the control group. Conversely, pre-treatment with DZN significantly reduced serum inflammatory markers and caspase-3 levels in tissue. The findings suggest that daidzein has anti-inflammatory and anti-apoptotic properties, potentially offering protection against IFO-induced neurotoxicity in rats.

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Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers

Hammoodi,

Al-Shawi

2023

JMedLife

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“…Then, the blood was spun in a centrifuge for 15 minutes at 3000 rpm to gain the serum. 10 The collected serum was used to determine the cardiac biomarkers (LDH and CK-MB) and the pro-inflammatory mediators (TNFα, IL-6, and IL-1β). Bioassay Technology Laboratory, China provided all ELISA kits; details are presented in Table 1 below.…”

Section: Experimental Designmentioning

confidence: 99%

Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: An observational study

Fadhel

Hassan²

2023

F1000Res

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Background: Doxorubicin is a crucial anticancer medication, however, cardiotoxicity is a severe adverse effect of doxorubicin therapy. Various mechanisms, including inflammation, have been postulated to account for this negative effect. The omega-7 fatty acid is a polyunsaturated fatty acid with anti-inflammatory and antioxidant properties. Therefore, the study's objective was to see whether omega-7 had any possible protective benefits against doxorubicin-induced cardiotoxicity in male rats. Methods: 28 male Wister rats were split into four groups (seven per group). Group 1 (negative control): healthy animals received normal saline orally as the vehicle for eight successive days and were sacrificed on day nine. Group 2 (positive control): animals that received a single dose of doxorubicin hydrochloride (IP 15mg/kg) were sacrificed the next day. Group 3: the animals were administered omega-7 orally at a 100 mg/kg/day dose for eight days. A single injection of doxorubicin IP (15 mg/kg) was given on day nine. The animals were sacrificed on day 10. Group 4: the animal was administered omega-7 orally at a 300 mg/kg/day dose for eight days. A single injection of doxorubicin IP (15 mg/kg) was given on day nine. The animals were sacrificed on day 10. Serum was collected and used to measure lactate dehydrogenase, creatinine kinase-MB, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta. Results: Lactate dehydrogenase and creatinine kinase-MB levels in group 3 (100mg/kg) were significantly lower than in group 2 (p>0.05) and significantly lower in group 4 (300mg/kg) than in group 2. Tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta levels were considerably lower in the omega-7-treated groups (100 and 300mg/kg) than in the positive control group (p<0.05). Conclusion: Through a mechanism involving the reduction of inflammation, omega-7 may preserve the cardiac tissue against doxorubicin-induced damage.

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“…After seven consecutive days of oral alpha-tocopherol administration (100 mg/kg), mice in this group received a solitary intraperitoneal dose of cisplatin (10 mg/ kg) on the eighth day [19][20][21][22][23][24]. After a twenty-four-hour interval since the last administered dose, blood samples were collected from the mice, which were subsequently euthanized by cervical dislocation.…”

Section: Group 5 -Alpha-tocopherol Treatment Vitamin E (At)mentioning

confidence: 99%

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

Abd Alhusen,

Hasan

2023

JMedLife

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Fatty acids, particularly omega-3, omega-6, and omega-9, play a vital role in various biological processes. As the body cannot synthesize omega-3 and omega-6, dietary sources of these fatty acids are essential. Each omega fatty acid has a distinct chemical structure, source, and function. Cisplatin (CP) treatment is known to cause acute kidney injury (AKI) due to its inflammatory effects. This study explored the renoprotective potential of omega-3-6-9 when co-administered with cisplatin in a mice model. We divided adult mice into five groups: a control group received 0.5 ml of liquid paraffin; a cisplatin-only group; two groups were treated with low (50 mg/kg) and high (100 mg/kg) doses of omega-3-6-9 plus cisplatin; and a final group received vitamin E before cisplatin administration. The administration of omega-3-6-9 significantly decreased pro-inflammatory modulators and kidney function markers such as TNF-α, IL-1β, blood urea nitrogen, and creatinine, indicating potential renoprotective effects. Our research concluded that omega-3- 6- 9 had anti-inflammatory properties and was effective against the harmful effects of cisplatin.

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The Ameliorative Effect of Fimasartan against Methotrexate-Induced Nephrotoxicity in Rats

Cited by 7 publications

References 23 publications

Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers

Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers

Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: An observational study

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

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