The ambrosanolide cumanin inhibits macrophage nitric oxide synthesis: some structural considerations

Lastra, Ana; Ramírez, T.O.; Salazar, Luis A.; Martínez, María José Abad; Trujillo‐Ferrara, José G.

doi:10.1016/j.jep.2004.07.020

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…Thus, by using in vitro and in vivo toxicity assays, we demonstrated the non-toxic effect of cumanin at the doses used. These results are in agreement with those reported by Lastra et al [39], who found that cumanin produces low cytotoxicity on peritoneal murine macrophages.…”

Section: Discussionsupporting

confidence: 94%

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

et al. 2013

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Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two other STLs, psilostachyin and cordilin, and one sterol glycoside, daucosterol, were isolated from A. scabra. Cumanin and cordilin were active against Trypanosoma cruzi epimastigotes showing 50% inhibition concentrations (IC50) values of 12 µM and 26 µM, respectively. Moreover, these compounds are active against bloodstrean trypomastigotes, regardless of the T. cruzi strain tested. Psilostachyin and cumanin were also active against amastigote forms with IC50 values of 21 µM and 8 µM, respectively. By contrast, daucosterol showed moderate activity on epimastigotes and trypomastigotes and was inactive against amastigote forms. We also found that cumanin and psilostachyin exhibited an additive effect in their trypanocidal activity when these two drugs were tested together. Cumanin has leishmanicidal activity with growth inhibition values greater than 80% at a concentration of 5 µg/ml (19 µM), against both L. braziliensis and L. amazonensis promastigotes. In an in vivo model of T. cruzi infection, cumanin was more active than benznidazole, producing an 8-fold reduction in parasitemia levels during the acute phase of the infection compared with the control group, and more importantly, a reduction in mortality with 66% of the animals surviving, in comparison with 100% mortality in the control group. Cumanin also showed nontoxic effects at the doses assayed in vivo, as determined using markers of hepatic damage.

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Section: Discussionsupporting

confidence: 94%

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

et al. 2013

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“…This is the case of A. cumanensis for example, which is used in pain treatment (Gupta, 1995). The species contains sesquiterpene lactones (Borges et al, 1983), which are important mediators of inflammation through inhibition of nitric oxide production (Lastra et al, 2004). No obvious correlation could be discovered between antioxidant capacity and these particular compounds.…”

Section: Correlation Of the Results Of The Testsmentioning

confidence: 99%

Antioxidant capacity and phenolic content of commonly used anti-inflammatory medicinal plants in Colombia

Jimenez

Carrillo-Hormaza

Pujol

et al. 2015

Industrial Crops and Products

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“…Synonyms of Ambrosia cumanenesis are A. californica ; A. coronopifolia ; A. psilostachya and Ambrosia rugelii ; these synonyms are provided to guide future researchers to future research; very little is currently available. The sesquiterpene lactone cumanin from Ambrosia psilostachya , exerted a high in vivo anti-inflammatory response, which was equivalent to that of helenalin (ED 50 = 6.33 and 13.11 μmol/kg, respectively) [31]. …”

Section: Resultsmentioning

confidence: 99%

Ethnomedicines used in Trinidad and Tobago for reproductive problems

Lans

2007

J Ethnobiology Ethnomedicine

166

105

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Background: Throughout history women have tried to control or enhance their fertility using herbal remedies, with various levels of societal support. Caribbean folk medicine has been influenced by European folk medicine, either through the early Spanish and French settlers or through the continuous immigration of Spanish-speaking peoples from Venezuela. Some folk uses are ancient and were documented by Galen and Pliny the Elder.

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The ambrosanolide cumanin inhibits macrophage nitric oxide synthesis: some structural considerations

Cited by 12 publications

References 26 publications

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

Antioxidant capacity and phenolic content of commonly used anti-inflammatory medicinal plants in Colombia

Ethnomedicines used in Trinidad and Tobago for reproductive problems

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