The alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung: a case report

Xu, Hong‐Tao; Lin, Xu‐Yong; Li, Qingchang; Wang, Enhua

doi:10.1186/1746-1596-7-137

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…It seems that survival correlates with the presence of lymph node metastasis. Nevertheless, the metastasis of low grade MEC of the lung is rare and low grade MECs have a much better prognosis than high grade carcinomas [ 21 ]. Patients with low grade MECs generally have a good prognosis, with a 5-year survival rate of 95%, and adjuvant treatment is considered unnecessary.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of pulmonary mucoepidermoid carcinoma

Shen

Che

2014

World J Surg Onc

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BackgroundMucoepidermoid carcinoma (MEC) of the lung is a rare malignant neoplasm. We aimed to investigate clinicopathological features, therapies, and prognoses of eight MEC cases.MethodsEight patients underwent surgical treatment for pulmonary MEC between 2005 and 2012 at the Thoracic Surgical Department of West China Hospital, Sichuan, China. The clinical data, radiological manifestation, treatment strategy, pathological findings, and prognoses of all patients were analyzed retrospectively.ResultsAmong the eight cases (four males and four females), the age of patients ranged from 35 to 71 years (mean age 50.67 years). Two tumors were located in the upper lobes and three masses were located in the lower lobes. The other three lumps were located in the left main bronchus, middle segmental bronchus of the right lobe, and trachea, respectively. The characteristics of the tumors were consistent with low grade MEC (n = 6) and high grade MEC (n = 2). All of the patients were sent for oncological evaluations, and three patients with N1 or N2 disease received chemotherapy. One of the patients died from brain metastasis at 15 months. Seven of the eight patients were alive at the time of evaluation. The median survival time was 40 (range 8 to 88) months.ConclusionMucoepidermoid tumors have to be treated by radical surgery with lymph node sampling and dissection. Patients with low grade tumors can be expected to be cured following complete resection. Careful histological typing plays a key role in prediction of late results, and further studies are needed.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of pulmonary mucoepidermoid carcinoma

Shen

Che

2014

World J Surg Onc

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“…The ectopic glands showed positive staining for ER, and the stromal cells were positive for both ER and CD10. Taken together, the possibility of pulmonary tumors exhibiting atypical microscopic changes could be ruled out [9,10], and the diagnosis of this case is endobronchial endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial endometriosis presenting as central-type lung cancer: a case report

Lin

Wang

et al. 2013

Diagn Pathol

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A 45-year-old female patient was referred to our hospital for complaining of dyspnea and coughing in the past four months. The computed tomography scanning demonstrated a central lesion in the upper lobe of the left lung close to the hilar, and the subsequent bronchoscopy revealed a polypoid lesion of the distal of the left main bronchus. This patient was diagnosed clinically as “possibly central-type lung cancer”. However, the pathologic result of the surgically excised polypoid lesion was endobronchial endometriosis.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1077439085928525

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“…Furthermore, in the lung, TTF-1 and napsin A are positive in approximately 75%-80% of adenocarcinomas, [103][104][105][106][107] whereas only one reported pulmonary MEC was TTF-1-positive. 88 Interestingly, EGFR mutations have been identified in 10%-25% of pulmonary MECs, 96,108,109 such that EGFR mutation does not exclude the possibility of MEC.…”

Section: Limited Datamentioning

confidence: 99%

Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

Naso,

Roden

2023

Histopathology

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Primary pulmonary salivary gland‐type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other pulmonary neoplasms. The majority of primary pulmonary salivary gland‐type tumours are malignant, with the most common entities being mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial‐myoepithelial carcinoma. Less commonly seen are myoepithelial carcinoma, hyalinizing clear cell carcinoma, acinic cell carcinoma, secretory carcinoma, salivary duct carcinoma, intraductal carcinoma, and polymorphous adenocarcinoma. Benign salivary gland‐type tumours of the lung include pleomorphic adenoma and sialadenoma papilliferum. Morphologic, immunophenotypic, and molecular features of these neoplasms are largely similar to salivary gland tumours elsewhere, and therefore the exclusion of metastatic disease requires clinical and radiologic correlation. However, the differential diagnostic considerations are different in the lung. The distinction of salivary gland‐type tumours from their histologic mimics is important for both prognostication and treatment decisions. Overall, salivary gland type‐tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high‐grade variants exist for many of these tumour types. Recent advances in our understanding of the spectrum of salivary gland‐type tumours reported in the lung and their diversity of molecular and immunohistochemical features have helped to refine the classification of these tumours and have highlighted a few differences between salivary gland‐type tumours of the lung and those primary to other sites.

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The alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung: a case report

Cited by 9 publications

References 13 publications

Clinicopathological analysis of pulmonary mucoepidermoid carcinoma

Clinicopathological analysis of pulmonary mucoepidermoid carcinoma

Endobronchial endometriosis presenting as central-type lung cancer: a case report

Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

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